The aim of the study was to evaluate anti-cariogenic effects Lactobacillus salivarius by reducing pathogenic species and biofilm mass in a double-species model. Coexistence S. mutans with C. albicans can cause dental caries progression or recurrence disease future. Fifty-nine children diagnosed early childhood (ECC) were recruited onto study. condition children's dentition defined according World Health Organization guidelines. participants divided into initial enamel demineralization...

ECC is a significant therapeutic and social problem global burden on public health. The aim of this clinical trial was to test whether 2-week daily consumption chewing tablets containing thermally inactivated L. salivarius reduces the 12-month caries increment compared control group. investigation single-center, randomized, controlled open-label, blinded end-point evaluation in two parallel groups. At baseline, 140 generally healthy children between 3 6 years age with or without were...

Sensory processing sensitivity (SPS) is a biologically determined trait that influences how individuals respond to external and internal stimuli. A high level of SPS characterized by three factors: increased emotional reactivity, heightened subtle stimuli, greater susceptibility overstimulation, all which may impact well-being health. This study examined the relationships between SPS, perceived stress, affect, biochemical responses in adult dental patients (N = 157) on day routine visit....

Recently, a continuous growth of interest has been observed in antimicrobial peptides (AMPs) the light an alarming increase resistance bacteria and fungi against antibiotics. AMPs are used as biomarkers diagnosis monitoring oral cavity pathologies. Therefore, determination specific protein profiles children diagnosed with early childhood caries (ECC) might be basis for effective screening tests specialized examinations which may enable progression disease. The objective studies was to...

Besides their structural catalytic and diverse regulatory functions, proteins are also precursors of many important biological compounds essential for normal functioning humans. Many these may be used as markers identification specific pathological states. A comprehensive knowledge about the metabolism salivary mechanisms action metabolites allowed development effective treatment disorders. However, it should not forgotten that in some conditions, only could involved pathogenesis but tool...

The aim of this study was to evaluate the role antioxidant barrier in saliva children with caries, and its impact on colonization cariogenic bacteria.This is a cross-sectional 81 aged 1-5 years. Antioxidant levels salivary bacterial profiles were measured. Patients divided into two groups as follows: initial stage decay, termed non-cavitated (1-2 International Caries Detection Assessment System (ICDAS)), extensive cavitated lesions (5-6 ICDAS). control group includes without caries.The...

Secondary caries is a disease associated with the formation of biofilm on border tooth and dental filling. Its development strongly influenced by dietary sweet foods type material. The aim study was to assess effect sweeteners ability clinical Streptococcus mutans strains form materials. Strains were isolated from plaque samples 40 pediatric patients 3–6 ICADS II group. tested composite glass ionomer materials used for milk teeth filling in presence sucrose, xylitol, sorbitol, erythritol....

The aim of the study was to verify hypothesis about differences in sweet taste perception group preschool children with and without caries, determine its relationship cariogenic microbiota frequency sweets consumption children. included 63 aged 2–6 years: 32 caries 31 caries. consisted collecting questionnaire data assessment dental status using decayed, missing, filled primary teeth index (dmft) International Caries Detection Assessment System (ICDAS II). evaluation carried out a specific...

The diagnosis of oral lichen planus (OLP) is based on clinical examination and histopathological criteria. Noninvasive diagnostics saliva may be considered as a confirmation OLP potential alternative to an invasive method. objective the present study was evaluate relationship between level tyrosine (Tyr) well antioxidants like uric acid (UA) glutathione peroxidase (GPx) activity in patients with comparison control group (healthy subjects without any changes). A total 40 healthy volunteers...

Streptococcus mutans is known to be a primary etiological factor of dental caries, widespread and growing disease in Polish children. Recognition novel features determining the pathogenicity this pathogen may contribute understanding mechanisms bacterial infections. The goal study was determine activity prephenate dehydrogenase (PHD) illuminate role enzyme S. pathogenicity. strains were biotyped based on STREPTOtest 24 biochemical identification tests usefulness biotyping determination...

Streptococcus mutans (MS) and its biotype I are the strains most frequently found in dental plaque of young children. Our results indicate that children pyruvate kinase (PK) activity increases significantly plaque, this corresponds with caries progression. The MS isolated study or their main glycolytic metabolism connected PK enzymes might be useful risk factors for studying pathogenesis target points novel therapies caries. relationship between activity, cariogenic biofilm formation...

One strategy in caries prevention is to inhibit the formation of cariogenic biofilms. Attempts are being made develop oral hygiene products enriched with various antimicrobial agents. them lactoperoxidase—an enzyme that can oxidise (pseudo)halide ions reactive activity. Currently, commercially available utilise thiocyanate as a substrate; however, several alternatives oxidised greater potential have been found. In this study, toxicity against human gingival fibroblasts lactoperoxidase system...

The lactoperoxidase (LPO) system shows promise in the prevention of dental caries, a common chronic disease. This has antimicrobial properties and is part non-specific immune system. Understanding efficacy LPO fight against biofilms could provide information on alternative strategies for treatment caries. In this study, enzymatic was modified using four different (pseudo)halide substrates (thiocyanate, thiocyanate-iodide mixture, selenocyanate, iodide). study evaluated effects such...

In order to investigate the suitability of Streptococcus mutans species biotyping by measuring activity selected enzymes from a commercial test, criteria were established for clinical strains children with dental caries. addition, relationships between biotypes, sensitivity commonly used antibiotics, and early childhood caries determined.A total 142 S. isolates plaque divided into different biotypes. Patients two groups: noncavitated (1-2 in ICDAS) cavitated (5-6 lesions. Biotyping...

Introduction. In 2016, 5-, 7- and 12-year-old children from the Małopolskie region were included in study of oral health as part Nationwide Monitoring Oral Health programme, which has been periodically implemented selected index groups Polish population since 1997. Aim. To evaluate prevalence level dental caries to observe trend this recent years relation population. Material methods. The covered 673 region, including 223 aged 5, 225 7 12 years. Dental condition/state dentition was examined...

The lactoperoxidase (LPO) system shows promise in the prevention of dental caries, a common chronic disease. This has antimicrobial properties and is part non-specific immune system. Understanding efficacy LPO fight against biofilms could provide information on alternative strategies for treatment caries. In this study, enzymatic was modified using four different (pseudo)halide substrates (thiocyanate, thiocyanate-iodide mixture, selenocyanate, iodide). study evaluated metabolic effects...