A5088557303- Synthesis and Reactivity of Heterocycles
- Synthesis and Characterization of Pyrroles
- HIV/AIDS drug development and treatment
- Synthesis and pharmacology of benzodiazepine derivatives
- Chemical synthesis and alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Cyclopropane Reaction Mechanisms
- Drug Transport and Resistance Mechanisms
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Activity
- Synthesis and Biological Evaluation
- Synthesis of Organic Compounds
- Synthesis and bioactivity of alkaloids
- Catalytic Cross-Coupling Reactions
Peoples' Friendship University of Russia
2016-2024
Russian New University
2019
Abstract This paper provides a review on various methodologies developed for the synthesis of different indolizine derivatives and an overview their application. These include thienoindolizine indolizino[8,7‐ b ]indole derivatives. The nucleus occurs as privileged scaffold many natural synthetic molecules with significant biological activity. Fused‐indolizines such thienoindolizines indolizinoindole are great interest, due to antitumor, antimicrobial enzyme inhibitor Because widespread use...
Previous studies showed that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1-a]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in tumor cells may reverse multidrug resistance (MDR) mediated by P-glycoprotein (P-gp). Herein, we synthesized evaluated for their antiproliferative activity four cell lines (RD, HCT116, HeLa, A549) ability of inhibiting P-gp-mediated MDR ten diversely substituted 1-Ph-DHPIQ...
Abstract Different Mannich base derivatives have been studied with the aim of addressing poor aqueous solubility recently disclosed 6‐phenethyl‐2,3,4,5‐tetrahydroazepino[4,3‐ b ]indol‐1(6 H )‐one ( 1 ), a human butyrylcholinesterase inhibitor (hBChE, IC 50 13 nM) and protective agent in NMDA‐induced neurotoxicity, vivo assays. The N ‐(4‐methylpiperazin‐1‐yl)methyl derivative 2 c showed 50‐fold increase pH 7.4‐buffered solution, high stability serum (half‐life >24 h) rapid (<3 min)...
A number of aza-heterocyclic compounds, which share the 5,6-dihydropyrrolo[2,1-a]isoquinoline (DHPIQ) scaffold with members lamellarin alkaloid family, were synthesized and evaluated for their ability to reverse in vitro multidrug resistance cancer cells through inhibition P-glycoprotein (P-gp) and/or multidrug-resistance-associated protein 1. Most investigated DHPIQ compounds proved be selective P-gp modulators, most potent modulator,...
Marine alkaloids belonging to the lamellarins family, which incorporate a 5,6-dihydro-1-phenylpyrrolo[2,1-a]isoquinoline (DHPPIQ) moiety, possess various biological activities, spanning from antiviral and antibiotic activities cytotoxicity against tumor cells reversal of multidrug resistance. Expanding series previously reported imino adducts DHPPIQ 2-carbaldehyde, novel aliphatic aromatic Schiff bases were synthesized evaluated herein for their in five diverse cell lines. Most newly...
Previous studies have shown that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1-a]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in tumor cells may reverse multidrug resistance (MDR) mediated by P-glycoprotein (P-gp). Herein, several novel substituted 1-Ph-DHPIQ derivatives were synthesized which carry carboxylate groups (COOH, COOEt), nitrile (CN) Mannich bases (namely, morpholinomethyl...
Abstract Review: 16 refs.