A5041098865- Synthesis and Reactivity of Heterocycles
- Synthesis and pharmacology of benzodiazepine derivatives
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Pyrroles
- Chemical synthesis and alkaloids
- Asymmetric Synthesis and Catalysis
- Coordination Chemistry and Organometallics
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of heterocyclic compounds
- Cancer therapeutics and mechanisms
- Cancer Treatment and Pharmacology
- Organic Chemistry Cycloaddition Reactions
- Chemical Reaction Mechanisms
- Cyclopropane Reaction Mechanisms
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Activity
- Synthesis of Organic Compounds
- Fluorine in Organic Chemistry
- Synthesis and bioactivity of alkaloids
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
Peoples' Friendship University of Russia
2015-2024
Russian New University
2017-2020
St Petersburg University
2010-2013
Saint Petersburg State University of Cinema and Television
1991-2009
NS Kurnakova Institute of General and Inorganic Chemistry
2003
University of Bari Aldo Moro
2000
Yıldız Technical University
1998
NationsUniversity
1991-1996
Southern Federal University
1993
A.V. Topchiev Institute of Petrochemical Synthesis
1990
An easy synthesis of novel highly functionalized 5,6-dihydroindolo[2,1-a]isoquinolines was developed via a pseudo four-component domino reaction 1-aroyl-3,4-dihydroisoquinolines, terminal α,β-ynones, and malononitrile. The selective formation this biologically relevant heterocyclic core achieved using one-pot approach under microwave irradiation. the same skeleton through 5,6-dihydropyrrolo[2,1-a]isoquinolines with malonic acid dinitrile supports proposed mechanism, involving intermediate...
Simple and efficient strategies have been developed for the synthesis of three structurally diverse dipyrrolo[1,2‐a:2',1'‐c][1,4]benzodiazepine (DPBD) derivatives. Firstly, two‐component reaction between 4‐aroylpyrrolo[1,2‐a][1,4]benzodiazepines electron‐deficient internal alkynes in different conditions was applied to obtain isomeric geminal vicinal DPBDs (gem vic). Secondly, multicomponent from 2‐pyrrolylbenzylamine, arylglyoxal monohydrates same led formation other (vic’). These...
Abstract Different synthetic paths that produce the reduced quinoline cycle are discussed: among them intramolecular cyclization, intra‐ and inter [4+2] cycloaddition reactions other methods. Some chemical properties of tetrahydroquinolines also analyzed.
Abstract Hydrogenated γ‐carbolines underwent tandem piperidine ring cleavage on treatment with dimethyl acetylenedicarboxylate (DMAD) or ethyl propiolate (EP) in the presence of alcohols, producing 3‐alkoxymethyl‐substituted indoles high yields. These compounds were cyclized to tetrahydroazocino[4,5‐ b ]indoles AlCl 3 . β‐carbolines produced tetrahydroazocino[5,4‐ directly upon EP ethanol. The resulting azocinoindole derivatives subjected a preliminary evaluation their vitro...
The tandem [4+2] cycloaddition between hexafluoro-2-butyne and bis-furyl dienes, like difurfuryl ester, at room temperature leads to the kinetically controlled "pincer"-adducts - annulated 4a,8a-bis(trifluoromethyl)hexahydro-1,4:5,8-diepoxynaphthalenes. On other hand, if these reactions proceed 140 °C, only thermodynamically "domino"-adducts 2,3-bis(trifluoromethyl)hexahydro-1,4:5,8-diepoxynaphthalenes are formed. Therefore, a very rare unexpected example of full kinetic thermodynamic...
(Het)Arylallenes undergo hydrosulfonylation under photoredox-catalyzed conditions. The reaction gives vinyl sulfones in a regio- and diastereoselective manner, employing sodium sulfinates as the sulfonyl source eosin Y photocatalyst. Indol-1-yl, pyrrol-1-yl, phenyl, naphtylallenes might be used. Aliphatic allenes are incompatible with
Previous studies showed that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1-a]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in tumor cells may reverse multidrug resistance (MDR) mediated by P-glycoprotein (P-gp). Herein, we synthesized evaluated for their antiproliferative activity four cell lines (RD, HCT116, HeLa, A549) ability of inhibiting P-gp-mediated MDR ten diversely substituted 1-Ph-DHPIQ...
A route towards pyrrolo[2,1-<italic>a</italic>]isoquinolines through a 3CR of 1-aroyl dihydroisoquinolines, activated alkynes and alcohols has been developed.
The reaction of 1,2-disubstituted 2-imidazolines with electron-deficient alkynes proceeds as a pseudo-three-component process and forms imidazolidines an N-vinylpropargylamine fragment. Heating the resulting in xylene on air leads to effective formation polysubstituted pyrroles through domino sequence aza-Claisen rearrangement/transannular nucleophilic addition/oxidative ring opening reactions. direct one-pot transformation has been also realized.
The published data on the intramolecular Diels–Alder reaction in compounds of 2-alkenylfuran series are generalised. methods and conditions for preparation tricyclic systems considered. effects substituents furan unsaturated fragments cycloaddition discussed. application this to synthesis alkaloids terpenoids is exemplified.
A new class of trifluoromethyl building blocks─2-trifluoromethyl allyl chlorides─have been obtained through a photoredox-catalyzed chlorotrifluoromethylation aryl allenes. The reaction proceeded in regio- and stereoselective manner. trifluoromethylated analog the flunarizine drug was synthesized.
In this paper, we propose a simple synthesis of isoindoline-4-carboxylic acids by means the aromatization 3a,6-epoxyisoindoles in alkaline media. The method is facile from an experimental point view: short-term (0.5–2h) reflux epoxyisoindoles 5% aqueous solutions alkali leads to target products 40–90% yields. absence by-products, ease isolation and applicability acidophobic group bearing substrates favorably distinguishes proposed procedure previously utilized acid-catalyzed methods....
An unprecedented electrochemical three-component reaction of phenylacetylene, sulfinate, and N-(formyl)anilide was discovered. The transformation occurs in an undivided cell with a graphite anode cathode DMF the presence tetrabutylammonium iodide as electrolyte. addition silver(I) oxide catalytic amounts iodine facilitated significantly. also carried out under photoredox-catalyzed conditions.