A5021613239- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Intraperitoneal and Appendiceal Malignancies
- Climate Change Policy and Economics
- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
Amsterdam University Medical Centers
2021-2024
Oncode Institute
2021-2024
University of Amsterdam
2020-2024
The tissue dynamics that govern maintenance and regeneration of the pancreas remain largely unknown. In particular, presence nature a cellular hierarchy remains topic debate. Previous lineage tracing strategies in relied on specific marker genes for clonal labeling, which left other populations untested failed to account potential widespread phenotypical plasticity. Here we employed system depends replication-induced marks. We found that, homeostasis, steady acinar replacement events...
Peritoneal metastases (PMs) from colorectal cancer (CRC) respond poorly to treatment and are associated with unfavorable prognosis. For example, the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) cytoreductive surgery in resectable patients shows limited benefit, novel treatments urgently needed. The majority CRC-PMs represent CMS4 molecular subtype CRC, here we queried vulnerabilities this pharmacogenomic databases identify therapies. This reveals copper ionophore elesclomol...
The tissue dynamics that govern maintenance and regeneration of the pancreas remain largely unknown. In particular, presence nature a cellular hierarchy remains topic debate. Previous lineage tracing strategies in relied on specific marker genes for clonal labeling, which leaves other populations untested fails to account potential widespread phenotypical plasticity. Here we employed system depends replication-induced marks. We found homeostasis, steady acinar replacement events characterize...