A5053055795- Intraperitoneal and Appendiceal Malignancies
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Gastrointestinal motility and disorders
- Agriculture, Water, and Health
- T-cell and B-cell Immunology
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
Cancer Genomics Centre
2024
University Medical Center Utrecht
2024
Amsterdam University Medical Centers
2021
University of Amsterdam
2021
University of Maryland, College Park
2020
Stromal-derived follicular dendritic cells (FDCs) are essential for germinal centers (GCs), the site where B maturate their antibodies. FDCs present native antigen to and maintain a CXCL13 gradient form cell follicle. Yet despite role, transcriptome of human remains undefined. Using single-cell RNA sequencing microarray, we provided these enigmatic as comprehensive resource. Key genes were validated by flow cytometry microscopy. Surprisingly, marginal reticular (MRCs) rather than expressed...
Peritoneal metastases (PMs) from colorectal cancer (CRC) respond poorly to treatment and are associated with unfavorable prognosis. For example, the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) cytoreductive surgery in resectable patients shows limited benefit, novel treatments urgently needed. The majority CRC-PMs represent CMS4 molecular subtype CRC, here we queried vulnerabilities this pharmacogenomic databases identify therapies. This reveals copper ionophore elesclomol...