A5050459217- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Click Chemistry and Applications
- MicroRNA in disease regulation
- Advanced Proteomics Techniques and Applications
- RNA modifications and cancer
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Microbial Natural Products and Biosynthesis
- RNA and protein synthesis mechanisms
- Synthesis of β-Lactam Compounds
- Luminescence and Fluorescent Materials
- Organoboron and organosilicon chemistry
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Radical Photochemical Reactions
- Photosynthetic Processes and Mechanisms
- Organophosphorus compounds synthesis
- Heat shock proteins research
- Antimicrobial Peptides and Activities
- Lipid metabolism and biosynthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
Max Planck Institute of Molecular Physiology
2024-2025
Leibniz Institute for Analytical Sciences - ISAS
2021-2023
Chinese Academy of Sciences
2017
University of Chinese Academy of Sciences
2017
Chengdu University
2017
Chengdu Institute of Biology
2017
National Taiwan University
2013
Emerging evidence indicates that lipid droplets (LDs) play important roles in metabolism, energy homeostasis, and cell stress management. Notably, dysregulation of LDs is tightly linked to numerous diseases, including lipodystrophies, cancer, obesity, atherosclerosis, others. The pivotal physiological have led an exploration research recent years. functions are inherently connected the composition their proteome. Current methods for profiling LD proteins mostly utilize fractionation, those...
A facile copper-catalyzed one-pot method for the synthesis of β-ketophosphine oxides has been developed <italic>via</italic> aerobic oxidative coupling ketones with P(O)–H compounds assisted by TBSOTf at room temperature.
A simple and convenient copper‐catalyzed direct oxyphosphorylation of enamides with P(O)‐H compounds dioxygen has been developed under mild conditions. This methodology can allow the synthesis a series valuable β ‐ketophosphine oxides/ ‐ketophosphonates in moderate to good yields broad substrate scope simply by using readily‐available starting materials.
Abstract Cellular homeostasis relies on precise regulation through chemical processes, such as protein posttranslational modifications (PTM) and physical biomolecular condensation. Aging disrupts this balance, increasing susceptibility to diseases death. However, the mechanisms behind age-related pathogenesis remain elusive. In study, we dissected various cysteine PTMs their impact protein-mediated condensation in aging brain. Our findings reveal that is associated with significant...
Aberrant miRNA expression has been associated with a large number of human diseases. Therefore, targeting miRNAs to regulate their levels become an important therapy against diseases that stem from the dysfunction pathways regulated by miRNAs. In recent years, small molecules have demonstrated enormous potential as drugs (i.e., SM-miR). A clear understanding mechanism action on upregulation and downregulation allows precise diagnosis treatment oncogenic pathways. However, outside slow costly...
A new transition-metal-free PhI(OAc)<sub>2</sub>-promoted highly selective hydroboration of terminal alkynes with bis(pinacolato)diboron has been developed at room temperature under air.
Photoaffinity labeling followed by tandem mass spectrometry is an often used strategy to identify protein targets of small-molecule drugs or drug candidates, which, under ideal conditions, enables the identification actual binding site. In case bioactive peptides, however, identifying distinct site hampered because complex fragmentation patterns during spectrometry. We here report development and use small cleavable photoaffinity reagents that allow functionalization peptides for...
A new class of push–pull dyes with long-wavelength emission based on benzodioxazole scaffolds have been synthesized.
Intramembrane serine proteases (rhomboid proteases) are involved in a variety of biological processes and implicated several diseases. Here, we report 4-oxo-β-lactams as novel scaffold for inhibition rhomboids. We show that they covalently react with the active site covalent bond is sufficiently stable detection rhomboid-lactam complex. 4-Oxo-β-lactams may therefore find future use both inhibitors activity-based probes rhomboid proteases.
Abstract Pexophagy, the selective degradation of peroxisomes, is essential for removing excess or dysfunctional and its dysregulation linked to various diseases. Previous research has shown that optineurin (OPTN), an autophagy receptor involved in mitophagy, aggrephagy, xenophagy, can induce pexophagy HEK-293 cells. However, underlying mechanism remains unclear. In this study, we used proximity labeling identify PEX14, a peroxisomal membrane protein, as neighboring partner OPTN. Biochemical...
Aspartic proteases are a small class of implicated in wide variety human diseases. Covalent chemical probes for photoaffinity labeling (PAL) these underdeveloped. We here report full on-resin synthesis clickable PAL based on the natural product inhibitor pepstatin incorporating minimal diazirine reactive group. The position this group determines efficiency. most effective sensitively detect cathepsin D, biomarker breast cancer, cell lysates. Moreover, through proteomics experiments and deep...
Photoaffinity labeling followed by tandem mass spectrometry is an often used strategy to identify protein targets of small molecule drugs or drug candidates, which -- under ideal conditions enables the identification actual binding site. In case bioactive peptides, however, identifying distinct site hampered because complex fragmentation patterns during spectrometry. We here report development and use cleavable photoaffinity reagents that allow functionalization peptides for light-induced...
Abstract Aberrant miRNA expression has pervasively been found to relate a growing number of human diseases. Therefore, targeting miRNAs regulate their levels become an important therapy against diseases that stem from the dysfunction oncogenic pathways regulated by miRNAs. In recent years, small molecule compounds have demonstrated enormous potential as drugs ( i . e ., SM-miR). A clear understanding mechanism action molecules on down- and up-regulating allows precise diagnosis treatment...