A5007351414- Cellular transport and secretion
- Connexins and lens biology
- Lipid Membrane Structure and Behavior
- Cancer-related Molecular Pathways
- Face recognition and analysis
- Microtubule and mitosis dynamics
- Face Recognition and Perception
- Ocular Oncology and Treatments
- Biochemical effects in animals
- Biomedical Research and Pathophysiology
- Glycosylation and Glycoproteins Research
- S100 Proteins and Annexins
- Enzyme Structure and Function
- Silk-based biomaterials and applications
- Acute Myeloid Leukemia Research
- Virus-based gene therapy research
- Photoreceptor and optogenetics research
- Veterinary Equine Medical Research
- Retinal Development and Disorders
- Viral-associated cancers and disorders
- Advanced Glycation End Products research
- Retinoids in leukemia and cellular processes
- Chronic Lymphocytic Leukemia Research
- Protein Structure and Dynamics
- RNA Interference and Gene Delivery
Birkbeck, University of London
2015-2018
University of Pittsburgh
2000-2006
Balfour Beatty (United Kingdom)
2005
Mount Sinai Hospital
2002
Institute of Cancer Research
1998-1999
Wayne State University
1982-1984
Phosphatidylinositols (PI) play important roles in regulating numerous cellular processes including cytoskeletal organization and membrane trafficking. The control of PI metabolism by phosphatidylinositol kinases has been the subject extensive investigation; however, little is known about how regulate traffic polarized epithelial cells. Because 4-kinase (PI4K)-mediated 4-phosphate (PI(4)P) production suggested to biosynthetic yeast mammalian cells, we have examined role PI4Kβ protein...
The function of acidification in protein sorting along the biosynthetic pathway has been difficult to elucidate, part because reagents used alter organelle pH affect all acidified compartments and are poorly reversible. We have a novel approach examine role polarized Madin-Darby canine kidney (MDCK) cells. expressed influenza virus M2 protein, an acid-activated ion channel that equilibrates lumenal cytosolic pH, MDCK cells examined consequences on targeting delivery apical basolateral...
Older adults tend to perform more poorly than younger on emotional expression identification tasks. The goal of the present study was test a processing mechanism that might explain these differences in emotion recognition—specifically, age-related variation utilization specific visual cues. Seventeen and 17 older completed reverse-correlation categorization task (Bubbles paradigm), consisting large number trials each which only part information used convey an facial revealed participants....
The cytoskeletal proteins of the human lens were studied by SDS-PAGE, 2-D electrophoresis and immunologically. Spectrin, vimentin actin identified in superficial fiber cells lenses even to age 87 years.These are lost from deeper cortical nuclear cells, where a broad zone acidic protein (36–42 Kd) emerges transparent normal lens. Age-related changes water-soluble fraction include increased prominence 56 Kd 36 cortex, 38 nucleus.
Polarized epithelial cells efficiently sort newly synthesized apical and basolateral proteins into distinct transport carriers that emerge from the trans-Golgi network (TGN), this sorting is recapitulated in nonpolarized cells. While targeting signals of basolaterally destined are generally cytoplasmically disposed, not typically accessible to cytosol, machinery required for segregation export cargo remains largely unknown. Here we investigated molecular requirements TGN marker influenza...
The synthesis of cytoskeletal and membrane polypeptides the chick lens epithelium, superficial cortical fiber cells deep was studied in organ-cultured lens. synthetic activity restricted to epithelium while were synthesized by as well. None observed be nuclear cells.
The ability to accurately determine the emotional state of others is critical for successful social functioning. However older adults can demonstrate selective difficulties in identifying negative emotions from faces while identify positive preserved. In younger categorization facial expressions emotion has been shown rely on processing specific subsets visual information (e.g. broadly smiling mouth happiness, wide open eyes fear)1,2. it remains unclear whether healthy process same cues as a...