A5013249515- Dermatology and Skin Diseases
- Skin Protection and Aging
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Monoclonal and Polyclonal Antibodies Research
- Probiotics and Fermented Foods
- melanin and skin pigmentation
- Systemic Lupus Erythematosus Research
- Digestive system and related health
- Gut microbiota and health
- Cell Adhesion Molecules Research
- Allergic Rhinitis and Sensitization
- Osteoarthritis Treatment and Mechanisms
- Acne and Rosacea Treatments and Effects
- Indoor Air Quality and Microbial Exposure
- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
- Rheumatoid Arthritis Research and Therapies
- Immunotherapy and Immune Responses
- Bee Products Chemical Analysis
- Health, Environment, Cognitive Aging
- Textile materials and evaluations
- MicroRNA in disease regulation
Cosmetics Europe
2021
Karolinska Institutet
2011-2019
Significance We identified a previously undescribed disease mechanism for psoriasis (Ps) and arthritis (PsA)-like by developing new mouse model having characteristic features similar to those of Ps PsA in human patients. Mannan-induced activation tissue macrophages triggers IL-17A secretion from γδ T cells, causing Ps-like inflammation. Such inflammation was significantly increased under reduced oxidative environment. Increased frequency monocytes/macrophages, depletion experiments, the...
Abstract Human skin microbiota might play an important role in maintaining health and potentially prevent premature ageing. The use of probiotics therapeutic applications is attractive idea, as it could offer alternative option for certain inflammatory disorders dry or sensitive skin. Here, we investigated the first time, a comparative study live lysate products probiotic strain Lactobacillus reuteri DSM 17938 topical using ex vivo models focusing on anti‐inflammatory barrier function vitro...
Rheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomeric matrix protein (COMP), elicit mechanical hypersensitivity in mice, uncoupled from visual, histological and molecular indications inflammation. Cartilage antibody-induced pain-like behavior does not depend on complement activation inflammation, but...
Abstract Background High demand on anti‐aging skin care encourage the improvement and development of more personalized formulations with additional benefits for general health age associated signs. The aging physical biological phenotypes manifest differently between diverse ethnic populations. A highly polluted environment can be viewed as an extrinsic factor accelerating process. Aim To develop a unique formula active complexes, having multifunctional effects anti‐pollution, brightening...
Abstract We have addressed the importance of B cell tolerance to collagen type II, a matrix protein, which is target in rheumatoid arthritis (RA) and its mouse models. generated germline-encoded anti-collagen II (CII) IgH replacement anti-C1 strain (ACB) investigate how CII, subverted further understand pathogenesis RA. Phenotypic analysis revealed that CII-specific cells were surprisingly neither deleted nor anergized. Instead, they readily detected all lymphoid organs. Spontaneously...
Autoantibody‐mediated inflammation contributes to the development of rheumatoid arthritis (RA), and anti‐type II collagen (CII) antibodies are present in serum, synovial fluid, cartilage RA patients. We had previously generated characterized knock‐in mice expressing a germline‐encoded, CII‐specific IgH (B10Q.ACB), which demonstrated positive selection self‐reactive B cells. Here, we show that despite spontaneous production autoantibodies, B10Q.ACB protected from collagen‐induced arthritis....
Abstract Introduction Acne is one of the most common skin concerns unknown etiology, often connected to menstrual cycle in women, and possibly microbial profile function. Objective We aimed investigate how hormonal fluctuation affects acne‐prone different populations relation clinical parameters profiles. Methods evaluated features by using biophysical topographical tools. For profiling, we sequenced facial microbiota associated findings with during phases cycle. Results identified...
Cao, D., I. Khmaladze, H. Jia, E. Bajtner, K. S. Nandakumar, T. Blom, J. A. Mo, and R. Holmdahl. 2011. Pathogenic autoreactive B cells are not negatively selected toward matrix protein collagen II. J Immunol . 187: [4451–4458][1]. There were several errors in the legend for [Fig. 3][2]. In
Our microbiota, a collection of micro-organisms is living ecosystem inside (gut) and outside (skin) our body.As part the inner outer barrier body, it plays an important role in maintaining health.One attractive approach to enhance health combat certain gut skin inflammatory diseases modulate microbiome using probiotics (live bacteria).Probiotics benefits on widely accepted, but we just started understand their use care formulations.The formats already adopted topical applications are live...
Our microbiota, a collection of micro-organisms is living ecosystem inside (gut) and outside (skin) our body.As part the inner outer barrier body, it plays an important role in maintaining health.One attractive approach to enhance health combat certain gut skin inflammatory diseases modulate microbiome using probiotics (live bacteria).Probiotics benefits on widely accepted, but we just started understand their use care formulations.The formats already adopted topical applications are live...