A5016879770- Mycotoxins in Agriculture and Food
- Carcinogens and Genotoxicity Assessment
- Veterinary medicine and infectious diseases
- Coccidia and coccidiosis research
- Wheat and Barley Genetics and Pathology
- Effects and risks of endocrine disrupting chemicals
- Microbial infections and disease research
- Agricultural safety and regulations
- Pharmacological Effects and Assays
- Meat and Animal Product Quality
- Selenium in Biological Systems
- Plant and fungal interactions
- Neuropeptides and Animal Physiology
- Agriculture, Plant Science, Crop Management
- Potato Plant Research
- Pesticide Residue Analysis and Safety
- Immunotoxicology and immune responses
- Animal Behavior and Welfare Studies
- Sperm and Testicular Function
- Phytoestrogen effects and research
- Diet and metabolism studies
- Plant Disease Resistance and Genetics
- Plant Pathogens and Resistance
- Toxin Mechanisms and Immunotoxins
- Thallium and Germanium Studies
University of Warmia and Mazury in Olsztyn
2015-2024
Uniwersytecki Szpital Kliniczny w Olsztynie
2007-2018
University of Computer Sciences and Economics in Olsztyn
2017
National Veterinary Research Institute
2009-2015
The objective of the study was to determine effect exposure pigs Fusarium mycotoxins zearalenone (ZEN) and deoxynivalenol (DON), administered together separately, on colon microbiota. An experiment conducted for 42 days gilts, randomly assigned four groups either ZEN, DON, ZEN+DON, or a placebo. number aerobic mesophilic bacteria, yeasts, molds, anaerobic Clostridium perfringens, fecal streptococci, Enterobacteriaceae, Escherichia coli, lactic acid bacteria (LAB) were determined in contents...
Deoxynivalenol is also known as vomitoxin due to its impact on livestock through interference with animal growth and acceptance of feed. At the molecular level, deoxynivalenol disrupts normal cell function by inhibiting protein synthesis via binding ribosome activating critical cellular kinases involved in signal transduction related proliferation, differentiation apoptosis. Because concerns deoxynivalenol, United States FDA has instituted advisory levels 5 µg/g for grain products most feeds...
Immature gilts were administered per os with zearalenone (ZEN) at 40 μg/kg BW (group Z, n = 9), deoxynivalenol (DON) 12 D, a mixture of ZEN and DON M, 9) or placebo C, over period six weeks. The pigs sacrificed after one, three, weeks the treatment (12 each time-point). Histological investigations revealed an increase in mucosal thickness crypt depth as well decrease ratio villus height to groups D M exposure mycotoxins. number goblet cells epithelium was elevated Z one week group three...
The contamination of feed with mycotoxins results in reduced growth, refusal, immunosuppression, and health problems. Deoxynivalenol (DON) zearalenone (ZEN) are among the most important mycotoxins. aim study was to examine effects low doses these on histological structure ultrastructure large intestine pig. performed 36 immature gilts mixed breed (White Polish Big × White Earhanging), which were divided into four groups administrated per os ZEN at 40 µg/kg BW, DON 12 a mixture (40 BW) (12 or...
The selection of high-protein raw materials that could be utilized in the production animal feed is limited Poland. aim this study was to analyze needs and possibilities associated with utilization insect protein nutrition In future, insects become an effective solution meeting nutritional requirements a growing population. Insect already used fish European Union (EU). Legislative decisions on introduction alternative source have based results studies investigating safety for farmed animals....
T-2 toxin is a mycotoxin produced by some Fusarium species, which may affect the synthesis of DNA and RNA causes various pathological processes. Till now, influence on enteric nervous system (ENS) located in wall gastrointestinal tract has not been studied. On other hand, cocaine- amphetamine-regulated transcript (CART) one neuronal factors, whose exact functions intestines still remain fully explained. The present study describes low doses CART-positive structures porcine stomach, duodenum,...
The enteric nervous system (ENS) can undergo adaptive and reparative changes in response to physiological pathological stimuli. These manifest primarily as alterations the levels of active substances expressed by neuron. While it is known that mycotoxins affect function central peripheral systems, knowledge about their influence on ENS limited. Therefore, aim present study was investigate low doses zearalenone (ZEN) T-2 toxin calcitonin gene related peptide-like immunoreactive (CGRP-LI)...
Zearalenone and deoxynivalenol are secondary metabolites of fungi the genus Fusarium. The presence mycotoxins in cereals resulting contamination feeds foods pose health risks for animals humans. dangers associated with high doses have been extensively researched but very little is known about NOAEL (No Observed Adverse Effect Level) or exposure to a combination (mixed mycotoxicoses). aim this study was determine effects six-week individual combined on subpopulations CD4+8−, CD4−8+ CD4+8+...
Zearalenone and its metabolites, α-zearalenol β-zearalenol, demonstrate estradiol-like activity disrupt physiological functions in animals. This article evaluates the carryover of zearalenone selected metabolites from digesta to intestinal walls (along entire intestines) pre-pubertal gilts exposed low doses over long periods time. The term “carryover” describes transfer mycotoxins feed edible tissues, it was used assess risk mycotoxin exposure for consumers. experimental with body weight up...
This study aimed to determine the dietary effects of honeybee pollen (BP) on growth parameters, intestinal microbiota, hepatic histoarchitecture, and histomorphometry African catfish Clarias gariepinus juveniles. The feeding experiment was carried out in a recirculating aquaculture system under controlled conditions for 21 days achieve more than 10-fold increase weight fish from control group. Fish were fed well-balanced commercial feed without any supplements served as reference group...
Abstract The immune system is one of the main toxicity targets T-2 toxin. In view scant research data demonstrating effect on cellular and humoral responses in gut-associated lymphoid tissue (GALT), this study set out to investigate effects chronic exposure low doses toxin (200 μg kg-1 feed) percentages CD4+ CD8+ T lymphocytes, CD4 + /CD8 double-positive CD21 B cells, IL-2, IFN-γ, IL-4 IL-10 mRNA expression levels porcine ileal Peyer’s patches. investigated material comprised ileum sections...
The aim of the study was to verify hypothesis that intoxication with low doses mycotoxins leads changes in mRNA expression levels nitric oxide synthase-1 and synthase-2 genes tissues gastrointestinal tract liver. experiment involved four groups immature gilts (with body weight up 25 kg) which were orally administered zearalenone a daily dose 40 μg/kg BW (group Z, n = 18), deoxynivalenol at 12 D, M, 18) or placebo C, 21) over period 42 days. lowest noted sixth week study, particular group M....
Zearalenone is a frequent contaminant of cereals and their by-products in regions with temperate climate. This toxic molecule produced naturally by Fusarium fungi crops. The aim this study was to determine the influence low zearalenone doses (LOAEL, NOAEL MABEL) on intestinal microbiome gilts different days exposure (days 7, 21 42). Intestinal contents were sampled from duodenal cap, third part duodenum, jejunum, caecum descending colon. experiment performed 60 clinically healthy average BW...