A5013275423- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Advanced Radiotherapy Techniques
- Meningioma and schwannoma management
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Vascular Malformations Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Medical Imaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Esophageal Cancer Research and Treatment
- Simulation Techniques and Applications
- Cardiac tumors and thrombi
- Prostate Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Prostate Cancer Treatment and Research
- Oral health in cancer treatment
- Lung Cancer Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Sarcoma Diagnosis and Treatment
- Ear and Head Tumors
- Effects of Radiation Exposure
- Nonmelanoma Skin Cancer Studies
Institut de Cancérologie de l'Ouest
2011-2020
Inserm
2011-2020
Centre National de la Recherche Scientifique
2013-2020
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2011-2020
Nantes Université
2013-2020
Emory University
2018
Institut Génétique Nantes Atlantique
2016-2017
Although endothelial cell apoptosis participates in the tumor shrinkage after single high-dose radiotherapy, little is known regarding vascular response conventionally fractionated radiation therapy. Therefore, we evaluated hypoxia, perfusion and microenvironment changes an orthotopic prostate cancer model of therapy at clinically relevant doses (2 Gy fractions, 5 fractions/week). First, decreased proliferation increased death with kinetics comparable to human radiotherapy. Secondly,...
Aim: We here hypothesized that tumor-derived exosomal miRNA (TexomiR) released from irradiated tumors may play a role in the tumor cells escape to natural killer (NK) cells. Materials & methods: Our study included use of different cancer cell lines, blood biopsies xenograph mice model and patients treated with radiotherapy. Results: The irradiation promotes TET2-mediated demethylation miR-378 promoter, miR-378a-3p overexpression its loading exosomes, inducing decrease granzyme-B (GZMB)...
Abstract Background Hypofractionated stereotactic radiotherapy (HFSRT) is indicated for large brain metastases (BM) or proximity to critical organs (brainstem, chiasm, optic nerves, hippocampus). The primary aim of this study was assess factors influencing BM local control after HFSRT. Then the effect surgery plus HFSRT compared with exclusive on oncologic outcomes, including overall survival. Materials and methods Retrospective conducted in Léon Bérard Cancer Center, included patients over...
Background. The tumor vasculature acts as an interface for the primary tumor. It regulates oxygenation, nutrient delivery, and treatment efficacy including radiotherapy. response of to different radiation doses has been disparately reported. Whereas high single can induce endothelial cell death, improved vascular functionality also described in a various dose range, few attempts have made reconcile these findings. Therefore, we aimed at comparing effects fractionation regimens on...
Dose calculation in preclinical context with a clinical level of accuracy is challenge due to the small animal scale and medium photon energy range. In this work, we evaluate effectiveness an analytical irradiator model combined Monte Carlo (MC) calculations irradiated volume calculate dose delivered by modern irradiator. A XRAD225Cx was created µ-RayStation 8B, treatment planning system, allowing arc static beams for seven cylindrical collimators. Calculations MC engine were compared EBT3...
Abstract The management of corticosteroids refractory chronic graft versus host disease ( cGVHD ) remains controversial. Retrospective analysis patients treated at the Integrated Center Oncology by total nodal irradiation TNI was performed to evaluate its therapy potency. delivers a dose 1 Gy in single session. delimitation fields is clinical (upper limit: external auditory meatus; lower mid‐femur). No pre‐therapeutic dosimetry scanner necessary. Evaluation efficacy measures 6 months after...
Purpose or ObjectiveModern pre-clinical radiotherapy allows to mimic 3D image-guided clinical but has be adapted small animal and target size constraints: beam size, targeting accuracy image resolution are scaled-down; energy is reduced from MV kV.In our institution, the XRAD225Cx µ-irradiator used for preclinical studies a Monte Carlo (MC) model (GATEv7) was previously created validated dose calculation in animals.However, typical MC environments do not provide same tools that available...