A5036174120- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- Glaucoma and retinal disorders
- Hallucinations in medical conditions
- Ophthalmology and Eye Disorders
- Meningioma and schwannoma management
- Ophthalmology and Visual Health Research
- Retinal and Optic Conditions
- Otitis Media and Relapsing Polychondritis
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Connexins and lens biology
- Ocular Oncology and Treatments
- Autopsy Techniques and Outcomes
- Folate and B Vitamins Research
- Ocular Diseases and Behçet’s Syndrome
- Congenital Diaphragmatic Hernia Studies
- Tactile and Sensory Interactions
- Cancer Genomics and Diagnostics
- Traumatic Ocular and Foreign Body Injuries
- Radiation Dose and Imaging
- Congenital gastrointestinal and neural anomalies
- Neurosurgical Procedures and Complications
- Medical Malpractice and Liability Issues
Royal Hallamshire Hospital
2017-2025
Sheffield Teaching Hospitals NHS Foundation Trust
2024
Manchester Royal Eye Hospital
2021-2022
University of Sheffield
2020-2022
Newcastle University
2011-2015
Royal Victoria Infirmary
2010-2015
Neurosciences Institute
2014
Newcastle Hospitals - Campus for Ageing and Vitality
2011-2012
University of Oxford
2008
We have identified an ethylnitrosourea (ENU)-induced recessive mouse mutation (Vcc) with a pleiotropic phenotype that includes cardiac, tracheoesophageal, anorectal, anteroposterior patterning defects, exomphalos, hindlimb hypoplasia, presacral mass, renal and palatal agenesis, pulmonary hypoplasia. It results from C470R in the proprotein convertase PCSK5 (PC5/6). Compound mutants (Pcsk5(Vcc/null)) completely recapitulate Pcsk5(Vcc/Vcc) phenotype, as does epiblast-specific conditional...
BackgroundThis study aimed to assess whether semi-automated kinetic perimetry (SKP) enables the quantitation and monitoring of visual field loss in persons with idiopathic intracranial hypertension (PWIIH).MethodsWe conducted a retrospective review newly diagnosed PWIIH. We recorded baseline clinical data optic disc modified Frisén grade from fundal photographs. The SKP software calculated I4e I2e isopter areas target plotted blind spot areas. This was for each eye at visit up 1...
Purpose To assess the impact of cataract surgery on cognition, mood, and visual hallucinations in a cohort patients aged 75 years older. Setting Secondary care ophthalmology unit Northeast England. Design Prospective observational study. Methods Participants or older with bilateral scheduled for were recruited consecutively. assessed preoperatively followed 1 year postoperatively. Cognition was using revised Addenbrooke's Cognitive Examination (ACE-R), mood measured 15-item Geriatric...
Purpose: Common age-related eye diseases including glaucoma, cataract and macular degeneration (AMD) have been proposed to be associated with dementia. Few studies examined the relationship between cognition or glaucoma. We explored association glaucoma diagnoses in community-dwelling 85-year-olds.Methods: Cross-sectional analysis of data from Newcastle 85+ Study. Diagnoses disease were extracted family practice records. Cognitive performance was assessed by standardized mini-mental state...
Background: visual and cognitive impairments are common in later life. Yet there very few screening tests for the visually impaired. Objective: to screen impairment Methods: case–control study including 150 elderly participants with (n = 74) a control group without 76) using vision-independent (MMSE clock drawing (CDT)) which part vision dependent. Results: scoring of two groups did not differ tests. Visually impaired patients performed poorer than controls vision-dependent items MMSE (T...
Background: cognitive test scores and visual acuity are strongly associated in older people. This may be due to poor vision limiting performance on tasks specifically requiring vision, or an association between neurodegenerative disorders. Objective: explore, using data from the Newcastle 85+ cohort study, impact of sight impairment (SI) Mini-Mental State Examination (MMSE) whether reduced among SI participants limited vision. Results: 839 aged 85 years, 44 (5.2%) were registered SI. Median...
Purpose: To identify the impact COVID-19 lockdown had on presentation and management of sight-threatening ocular trauma.
<h3>Background/aims</h3> To assess the impact of impaired cognition on visual outcomes 1 year following cataract surgery in a cohort older people. <h3>Methods</h3> Participants aged 75 years or more with bilateral and scheduled for were recruited consecutively. Cognition was assessed using revised Addenbrooke9s cognitive examination (ACE-R). divided into two groups: normal (ACE-R ≥88) <88). Visual quality life (VQOL) logarithm minimum angle resolution acuity (VA) at baseline surgery....
In light of the growing number people with dementia and age-related cataract, as well changing anesthetic practices for cataract surgery, this study aimed to explore experiences surgeons in managing patients making decisions.
This is a case report describing an unusual presentation of acute painful diplopia that led to the diagnosis VEXAS syndrome. (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome adult-onset monogenic auto-inflammatory disease due somatic UBA1 gene mutation in haematopoietic progenitor cells. Our patient was 67-year-old diabetic male who presented with eye movements associated diplopia, left periorbital pain and swelling. Imaging revealed inflammatory process involving multiple...
Background: Papilloedema and visual failure can occur as a consequence of vestibular schwannoma without evidence hydrocephalus on imaging. Conventional treatment usually includes CSF diversion procedures. We describe here the novel use optic nerve sheath fenestration in these patients. Methods: A case series three patients who underwent for complications schwannoma. Results: Patients B were both 23 year old females, with symptoms papilloedema at time presentation large Patient had...
Purpose: To establish the proportion of patients who are blind or have low vision prior to undergoing cataract surgery at tertiary referral centers in Tanzania. assess which patient groups presenting for more likely be visually impaired. Methods: Using pre-existing computerized audit systems we gathered data on pre-operative visual status, age, gender and presentation mode (walk-in outreach) 3765 4258 operations 2 hospitals Visual status was defined based better eye. Results: 32% were...
Background: There are increasing numbers of referrals to ophthalmology departments due blurred optic disc margins. In light this and the COVID-19 pandemic we aimed assess whether these patients could be safely assessed without direct contact between clinician patient. Methods: We retrospectively reviewed records consecutive seen in our ‘blurred clinic’ August 2018 October 2019. then presented anonymous information from their referral letter, visual fields nerve images two consultant...
Abstract Background/Aims VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a newly recognised adult-onset acquired autoinflammatory disease caused by somatic mutations of the UBA1 gene in blood precursor cells. It characterised systemic inflammation and haematologic abnormalities. Methods Here we report case 66 year old male who presented with orbital as one striking features his underlying VEXAS. Results Our patient has history type 1 insulin dependent diabetes,...