A5023680578- interferon and immune responses
- Immune Response and Inflammation
- Immune cells in cancer
- Vaccine Coverage and Hesitancy
- Immune responses and vaccinations
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Pluripotent Stem Cells Research
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Phagocytosis and Immune Regulation
- COVID-19 Impact on Reproduction
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Kruppel-like factors research
Spanish National Centre for Cardiovascular Research
2021-2025
Lancaster University
2018-2019
University of Dundee
2017
DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here we find that keratinocytes and other human cells mount an response within hours of etoposide-induced damage, which involves sensing adaptor STING but is independent cytosolic receptor cGAS. This non-canonical activation mediated binding protein IFI16, together with factors ATM PARP-1, resulting in assembly alternative signaling complex includes tumor suppressor p53 E3 ubiquitin ligase TRAF6....
Abstract Many human cells can sense the presence of exogenous DNA during infection though cytosolic receptor cyclic GMP-AMP synthase (cGAS), which produces second messenger (cGAMP). Other putative receptors have been described, but whether their functions are redundant, tissue-specific or integrated in cGAS-cGAMP pathway is unclear. Here we show that interferon-γ inducible protein 16 (IFI16) cooperates with cGAS sensing keratinocytes, as both and IFI16 required for full activation an innate...
MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. However, its mechanism action remains poorly understood. Here, we find intranasal prophylaxis with modulates the lung immune landscape and provides long-term heterologous infections in mice. Intranasal administration systemic candidiasis wild-type Rag1-deficient mice lacking functional lymphocytes, indicative innate...
Increased body temperature, both locally and systemically, is a key feature of the inflammatory response. Heat associated with increased blood flow to affected areas immune infiltrate, yet temperature has also been described have direct effects on cell function. In recent study, Heintzman, et al investigated effect febrile (39 °C) T They describe H 1 function fitness accompanied by decrease in regulatory suppressive These findings add another important consequence our understanding fever responses.
Replication stress is a key driver of DNA damage and genome instability. stress-induced fork remodelling generates new end that vulnerable to the action nucleases, which protected by range factors including canonical tumour suppressors BRCA1 BRCA2. Here we report replication drives elevated production cytokines chemokines in absence damage. The sensor IFI16 binds nascent at stalled forks signals via sensing adaptor STING, induce activation NF-κB pro-inflammatory response stress. also acts...
COVID-19-specific vaccines are efficient prophylactic weapons against SARS-CoV-2 virus. However, boosting innate responses may represent an innovative way to immediately fight future emerging viral infections or boost vaccines. MV130 is a mucosal immunotherapy, based on mixture of whole heat-inactivated bacteria, that has shown clinical efficacy recurrent respiratory infections. Herein, we show the intranasal administration this immunotherapy confers heterologous protection infection in...
Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe discovery of a signalling cascade that links DNA damage activation innate adaptor STING (STimulator INterfern Genes).