A5100774330- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- RNA Research and Splicing
- Cellular transport and secretion
- RNA Interference and Gene Delivery
- Breast Cancer Treatment Studies
- Infections and bacterial resistance
- Ferroptosis and cancer prognosis
- Phytase and its Applications
- Statistical Methods in Clinical Trials
- S100 Proteins and Annexins
- Circular RNAs in diseases
- Viral Infections and Immunology Research
- Pancreatic function and diabetes
- Mycobacterium research and diagnosis
- Bacteriophages and microbial interactions
- Plant Pathogenic Bacteria Studies
- Pneumonia and Respiratory Infections
- Cancer Risks and Factors
- Animal Genetics and Reproduction
- Erythrocyte Function and Pathophysiology
- Natural Compounds in Disease Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Ion channel regulation and function
Ningbo University
2024
Fujian Medical University
2024
Huashan Hospital
2020-2022
Fudan University
2020-2022
Hebei General Hospital
2022
Kunming University of Science and Technology
2021
Huazhong University of Science and Technology
2007-2019
Central Hospital of Wuhan
2019
Chicago Department of Public Health
2019
University of Chicago
2019
Background Long non-coding RNAs (lncRNAs) have been reported to modulate cardiovascular diseases, and expression dynamics of lncRNAs in the bloodstream were proposed be potential biomarkers for clinical diagnosis. However, few diseases-related circulating identified their prediction power has not investigated depth. Here we report a new lncRNA, atherosclerotic plaque pathogenesis associated transcript ( APPAT ), evaluated its role predicting ability development. Methods was analyzed screened...
To investigate molecular characteristics and antimicrobial susceptibility profiles of clinical isolates Elizabethkingia in Shanghai, China.Elizabethkingia were collected a university-affiliated hospital 2012-2015 2017-2018. They re-identified to species level by 16S rRNA gene species-specific sequencing. Antimicrobial testing, screening for metallo-beta-lactamase production, identification resistance genes pulsed-field gel electrophoresis (PFGE) performed.Among 52 isolates, E. anophelis was...
microRNAs are a class of small non-coding RNA molecules negatively regulating gene expression at post-transcriptional level in many tissues including the central nervous system. cAMP response element binding protein (CREB) is key nuclear factor highly expressed hippocampal neurons on which signal pathways converge. Recent studies have found that microRNA-181a rich mature nerve cells, and bioinformatics analysis shows CREB1 mRNA 3'-untranslated region (3'UTR) contains complementary sequence...
To evaluate in vitro activities of β-lactam antibiotics alone and combination with sulbactam at different ratios against Acinetobacter baumannii clinical strains from China.A total 300 isolates A. were collected 29 hospitals across China 2018. Susceptibility to common was assessed, β-lactamase genes detected. In activity ampicillin, cefoperazone imipenem tested the 2:1, 1:1, 1:1.5, 1:2, 1:2.5 1:3.High resistant rates for observed except tigecycline polymyxin B. Among carbapenem-resistant...
Hepatitis B virus (HBV) transcripts are subjected to multiple splicing decisions, but the mechanism of regulation remains poorly understood. In this study, we used a well‐investigated alternative reporter dissect regulatory elements residing in post‐transcriptional element (PRE) HBV. A strong intronic silencer (ISS) with minimal functional 105 nucleotides (referred as PRE‐ISS) was identified and, interestingly, both sense and antisense strands were found strongly suppress human cell lines....
To evaluate in vitro activities of sitafloxacin and comparators against the clinical isolates less common nonfermenting Gram-negative bacteria (NFGNB).The NFGNB were collected during a long period spanning five years from 2016 to 2020 Huashan Hospital, Fudan University Shanghai. A broth microdilution method was used determine minimum inhibitory concentrations (MICs) comparators.In terms MIC50/90 values, highly active Stenotrophomonas maltophilia (0.25/1 mg/L), Burkholderia cepacia complex...
Background: Radiotherapy is the primary treatment choice for Nasopharyngeal Carcinoma (NPC). However, its efficacy compromised due to radioresistance. Ferroptosis, a novel iron-dependent regulated cell death induced by Ionizing Radiation (IR), plays role in promoting cancer death. Yet, relationship between enhanced ferroptosis and increased sensitivity of NPC cells IR remains poorly understood. Objective: This study aimed explore association NPC, as well repressor SLC7A11 IR-treated cells....
The use of postmastectomy radiotherapy (PMRT) on women with AJCC (American Joint Committee Cancer) pT1-2pN1 breast cancer is controversial in practice.Huo et al. (2015) found that PMRT was associated longer survival among a high-risk subgroup patients using Cox model data from the National Cancer Database.To address unmeasured confounding this observational study, we consider variation facilities as an instrumental variable (IV).Recently, there has been widespread two-stage residual...
Abstract Hand, foot, and mouth disease caused by Coxsackievirus B5 (CV-B5) poses considerable threats to the health of infants especially in neurological damage. And long noncoding RNAs (lncRNAs) act pivotal factors regulating participating virus-host interactions. However, role lncRNAs CV-B5-host interactions has not yet been elucidated. In this study, we used RNA sequencing determine expression profiles CV-B5 infected human rhabdomyosarcoma (RD) SH-SY5Y cells. Our results identified that...