A5084974669- Autism Spectrum Disorder Research
- Family and Disability Support Research
- Child Nutrition and Feeding Issues
- CAR-T cell therapy research
- Child Development and Digital Technology
- Telemedicine and Telehealth Implementation
- Behavioral and Psychological Studies
- Cerebral Palsy and Movement Disorders
- Infant Development and Preterm Care
- Occupational Therapy Practice and Research
- Disability Education and Employment
- Genetics and Neurodevelopmental Disorders
- Eating Disorders and Behaviors
- Early Childhood Education and Development
- Child and Adolescent Psychosocial and Emotional Development
- Patient Satisfaction in Healthcare
- Global Energy and Sustainability Research
- Geotechnical Engineering and Soil Stabilization
- Geotechnical Engineering and Soil Mechanics
- Childhood Cancer Survivors' Quality of Life
- Reservoir Engineering and Simulation Methods
- Virus-based gene therapy research
- Geotechnical Engineering and Underground Structures
- Interprofessional Education and Collaboration
- Child and Animal Learning Development
Rush University
2017-2024
Center for Cancer Research
2020-2024
Rush University Medical Center
2018-2024
National Cancer Institute
2020-2024
National Institutes of Health
2020-2024
University of Illinois Chicago
2021
University of Kansas Medical Center
2013-2018
Mercer University
2018
Mercer University Health Sciences Center
2018
Arthur D. Little (United States)
2018
PURPOSE Patients with B-cell acute lymphoblastic leukemia who experience relapse after or are resistant to CD19-targeted immunotherapies have limited treatment options. Targeting CD22, an alternative antigen, represents alternate strategy. We report outcomes on the largest patient cohort treated CD22 chimeric antigen receptor (CAR) T cells. PATIENTS AND METHODS conducted a single-center, phase I, 3 + dose-escalation trial large expansion that tested CD22-targeted CAR cells for children and...
The purpose of this study was to examine sensory processing in children ages 3-14 years with autism spectrum disorder (ASD), attention deficit hyperactivity (ADHD), and typical development (TD) using the Sensory Profile 2nd Edition (Dunn, 2014).Participants included 239 (ASD = 77; ADHD 78; TD 84) matched on age gender. Multivariate analysis covariance used compare extent which three grsoups differed patterns (i.e., sensitivity, avoiding, registration, seeking) systems auditory, visual,...
Background Sensory features are highly prevalent and heterogeneous among children with ASD . There is a need to identify homogenous groups of based on sensory (i.e. subtypes) inform research treatment. Methods subtypes their stability over 1 year were identified through latent profile transition analysis ( LPTA ) national sample Data collected from caregivers ages 2–12 years at two time points (Time N = 1294; Time 2 884). Results Four (Mild; Sensitive‐Distressed; Attenuated‐Preoccupied;...
The objective of this study was to identify and synthesize research about how sensory factors affect daily life children. We designed a conceptual model guide scoping review published from 2005 October 2014 (10 years). searched MEDLINE, CINAHL, PsycINFO included studies perception/processing; children, adolescents/young adults; participation. excluded animals, adults, articles. Our process resulted in 261 articles meeting criteria. Research shows that children with conditions input...
Abstract OBJECTIVE. We investigated the efficacy of Occupation-Based Coaching delivered via telehealth for families young children with autism spectrum disorder (ASD). METHOD. Participants were 18 ASD ages 2–6 yr. used descriptive statistics to understand intervention characteristics and paired-sample t tests examine changes in parent child participation. RESULTS. Parents identified many areas adaptive behavior as goals. Results showed that various domains participation significantly...
This study examined the (a) feasibility of enrolling 12-month-olds at risk ASD from a community sample into randomized controlled trial, (b) subsequent utilization services, and (c) potential novel parent-mediated intervention to improve outcomes. The First Year Inventory was used screen recruit 12-month-old infants compare effects 6–9 months Adapted Responsive Teaching (ART) versus referral early monitoring (REIM). Eighteen families were followed for ~20 months. Assessments conducted before...
Occupational therapy services delivered via telehealth can support families of young children with autism spectrum disorders (ASD) in everyday routines such as mealtime, bedtime, and play. The aim the current study was to understand lived experiences parents who participated a 12-week, telehealth-delivered occupational intervention (Occupation-Based Coaching). We used semi-structured interviews subsequent thematic content analysis how perceived mechanism service delivery (i.e.,...
We evaluated the psychometric properties of Sensory Experiences Questionnaire (Version 1; Baranek, David, Poe, Stone, & Watson 2006), a brief caregiver questionnaire for young children with autism and developmental delays used to identify sensory processing patterns in context daily activities.Caregiver questionnaires (N=358) were analyzed determine internal consistency. The test-retest subsample (n=24) completed two assessments within 2-4 wk. Internal consistency reliability using...
Research with a sample of 400 preschool-aged children ASD suggests that sensory processing factors differentially contribute to developmental domains, the greatest contribution receptive and expressive language.
Intervention services positively impact outcomes of children with autism spectrum disorder (ASD) and their families. However, families face many burdens when accessing high-quality intervention such as availability providers, time, cost; these are often magnified for underserved Therefore, the purpose this study was to investigate acceptability ( n = 17) cost-effectiveness 18) a 12-week telehealth among young ASD. To understand intervention, caregivers completed questionnaire about process...
Sensory features are prevalent and heterogeneous across children with ASD these have been associated child outcomes. Identification of clinically defined sensory subtypes may enhance our understanding unique phenotypes that implications for etiology, prognosis, intervention. This longitudinal study used a national online survey aimed to identify associations previously validated specific family characteristics functional outcomes [vineland adaptive behavior scale‐II (VABS) parenting stress...
Chimeric antigen receptor T-cells (CART) are active in relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL), but relapse remains a substantial challenge. Reinfusion with the same CART product (CART2) patients suboptimal response or positive following first infusion (CART1) represents potential treatment strategy, though early experiences suggest limited efficacy of CART2 CD19 targeting. We report on our experience across host novel CAR T-cell trials. This was retrospective...
Cancer outcomes with chemotherapy are inferior in patients of minority racial/ethnic groups and those obesity. Chimeric antigen receptor (CAR) T-cell therapy has transformed for relapsed/refractory hematologic malignancies, but whether its benefits extend commensurately to minorities obesity is poorly understood. With a primary focus on B-cell acute lymphoblastic leukemia (B-ALL), we retrospectively evaluated the impact demographics CAR adult pediatric malignancies treated across 5 phase 1...
Hematologic toxicities, including coagulopathy, endothelial activation, and cytopenias, with CD19-targeted chimeric antigen receptor (CAR) T-cell therapies correlate cytokine release syndrome (CRS) neurotoxicity severity, but little is known about the extended toxicity profiles of CAR T-cells targeting alternative antigens. This report characterizes hematologic toxicities seen following CD22 their relationship to CRS neurotoxicity.
Sensory processing is a personal trait that can contribute to challenging behavior. Protective factors, such as resiliency, support children in managing their behavior, yet little research has addressed the contribution of sensory protective factors. Therefore, this cross-sectional study we aimed determine (using Profile-2) behavior and factors Behavior Assessment System for Children, 2nd ed., Parent Rating Scales) sample 51 ages 6-11 yr from general U.S.The results indicated avoiding...
This mixed methods study examined: 1) how young children with and without developmental disabilities delays participate in daycare or preschool activities; 2) similarities differences environmental factors impacting participation; 3) strategies used by parents who desired a change their child's participation.Data were drawn from 129 of (mean age = 49.3 months) residing North America. Summary item-level group based on disability status assessed for participation supports to participation....
Occupational therapy focuses on therapeutic means to address participation in meaningful everyday tasks across the lifespan. No single setting is more conducive this pursuit than individuals’ authentic contexts. therapists are therefore uniquely suited lead charge toward stimulating research and advancing evidence-based application of telehealth. To end, American Therapy Foundation digitally convened their 2020 Planning Grant Collective focus topic Telehealth. Participants interdisciplinary...
Coaching has been identified as a best practice for early intervention (EI) services provided through the Individuals with Disabilities Education Act (IDEA) Part C. The current study describes establishment and progress of research-relationship partnership to deliver coaching via telehealth during COVID-19 pandemic. Community-based EI providers implemented 9-weeks evaluated extent which child caregiver outcomes differed between families that had previously received in-person versus only....