A5034869715- Advanced X-ray Imaging Techniques
- Digital Holography and Microscopy
- Optical measurement and interference techniques
- Image Processing Techniques and Applications
- Advanced Electron Microscopy Techniques and Applications
- Astrophysical Phenomena and Observations
- Laser-Plasma Interactions and Diagnostics
- Geothermal Energy Systems and Applications
- Particle Accelerators and Free-Electron Lasers
- Traditional Chinese Medicine Analysis
- Aortic aneurysm repair treatments
- Cell Image Analysis Techniques
- Phytochemical compounds biological activities
- Metal and Thin Film Mechanics
- Bone Metabolism and Diseases
- Vascular Procedures and Complications
- Additive Manufacturing Materials and Processes
- Fuel Cells and Related Materials
- Pharmacological Effects of Natural Compounds
- Soil Moisture and Remote Sensing
- Metamaterials and Metasurfaces Applications
- Advanced Optical Sensing Technologies
- Medicinal Plant Pharmacodynamics Research
- Near-Field Optical Microscopy
- Aortic Disease and Treatment Approaches
Jiangsu University
2025
University of Connecticut
2019-2024
Liaoning Provincial People's Hospital
2024
Tangshan People's Hospital
2024
PLA Army Engineering University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2022
Hangzhou Dianzi University
2020
London Rebuilding Society
2020
China University of Petroleum, East China
2018-2019
Nanjing University of Aeronautics and Astronautics
2011
Ptychography is an enabling coherent diffraction imaging technique for both fundamental and applied sciences. Its applications in optical microscopy, however, fall short its low throughput limited resolution. Here, we report a resolution-enhanced parallel coded ptychography achieving the highest numerical aperture orders of magnitude greater than previous demonstrations. In this platform, translate samples across disorder-engineered surfaces lensless data acquisition. The engineered surface...
Abstract Fourier ptychography (FP) is an enabling imaging technique that produces high‐resolution complex‐valued images with extended field coverages. However, when FP a phase object any specific spatial frequency, the captured contain only constant values, rendering recovery of corresponding linear ramp impossible. This challenge not unique to but also affects other common microscopy techniques — rather counterintuitive outcome given their widespread use in imaging. The underlying issue...
Blu-ray drive is an engineering masterpiece that integrates disc rotation, pickup head translation, and three lasers in a compact portable format. Here we integrate blood-coated image sensor with modified for high-throughput cytometric analysis of various bio-specimens. In this device, samples are mounted on the rotating illuminated by built-in from head. The resulting coherent diffraction patterns then recorded sensor. rich spatial features blood-cell monolayer help down-modulate object...
The recent advent of whole slide imaging (WSI) systems has moved digital pathology closer to diagnostic applications and clinical practices. Integrating WSI with machine learning promises the growth this field in upcoming years. Here we report design implementation a handheld, colour-multiplexed, AI-powered ptychographic scanner for applications. This handheld is built using low-cost off-the-shelf components, including red, green, blue laser diodes sample illumination, modified stage...
We report a novel lensless on-chip microscopy platform based on near-field blind ptychographic modulation. In this platform, we place thin diffuser in between the object and image sensor for light wave By blindly scanning unknown to different x-y positions, acquire sequence of modulated intensity images quantitative recovery. Different from previous implementations, employ unit magnification configuration with Fresnel number ~50,000, which is orders magnitude higher than setups. The allows...
Conventional ptychography translates an object through a localized probe beam to widen the field of view in real space. Fourier spectrum pupil aperture expand bandwidth reciprocal Here we report imaging modality, termed synthetic (SAP), get best both techniques. In SAP, illuminate stationary using extended plane wave and translate coded image sensor at far for data acquisition. The layer attached on modulates exit waves serves as effective ptychographic phase retrieval. translation process...
We report an angle-tilted, wavelength-multiplexed ptychographic modulation approach for multispectral lensless on-chip microscopy. In this approach, we illuminate the specimen with lights at 5 wavelengths simultaneously. A prism is added illumination path spectral dispersion. Lightwaves different wavelengths, thus, hit slightly incident angles, breaking ambiguities in mixed state reconstruction. At detection path, place a thin diffuser in-between and monochromatic image sensor encoding...
Recent advancements in whole slide imaging (WSI) have moved pathology closer to digital practice. Existing systems require precise mechanical control and the cost is prohibitive for most individual pathologists. Here we report a low-cost high-throughput WSI system termed OpenWSI. The reported built using off-the-shelf components including programmable LED array, photographic lens, computer numerical (CNC) router. Different from conventional platforms, our performs real-time single-frame...
Fourier ptychographic microscopy (FPM) is a computational approach geared towards creating high-resolution and large field-of-view images without mechanical scanning. Acquiring color of histology slides often requires sequential acquisitions with red, green, blue illuminations. The reconstructions suffer from coherent artifacts that are not presented in regular incoherent images. As result, it remains challenge to employ FPM for digital pathology applications, where resolution accuracy...
Context Puerarin (Pue) and tanshinone IIA (Tan IIA) are often used in combination the treatment of cerebrovascular diseases.Objective To investigate neuroprotective effect synergic mechanism Pue-Tan on ischaemic stroke (IS).Materials methods IS was induced rats by middle cerebral artery occlusion (MCAO). Rats were intraperitoneally injected with Pue (36 mg/kg), Tan (7.2 or 7.2 mg/kg) for five times [30 min before ischaemia, immediately after reperfusion (0 h), 24, 48, 72 h reperfusion]....
Polarimetric imaging provides valuable insights into the polarization state of light interacting with a sample. It can infer crucial birefringence properties specimens without using labels, thereby facilitating diagnosis diseases such as cancer and osteoarthritis. In this study, we present novel polarimetric coded ptychography (pol-CP) approach that enables high-resolution, high-throughput gigapixel on chip. Our platform deviates from traditional lens-based systems by employing an integrated...
Abstract Synthetic aperture radar (SAR) utilizes an aircraft-carried antenna to emit electromagnetic pulses and detect the returning echoes. As aircraft travels across a designated area, it synthesizes large virtual improve image resolution. Inspired by SAR, we introduce synthetic ptycho-endoscopy (SAPE) for micro-endoscopic imaging beyond diffraction limit. SAPE operates hand-holding lensless fiber bundle tip record coherent patterns from specimens. The cores at distal modulate diffracted...
We present deep-ultraviolet Fourier ptychography (DUV-FP) for high-resolution chemical imaging of biological specimens in their native state without exogenous stains. This approach uses a customized 265-nm DUV LED array angle-varied illumination, leveraging the unique absorption properties biomolecules at this wavelength region. implemented robust feature-domain optimization framework to overcome common challenges ptychographic reconstruction, including vignetting, pupil aberrations, stray...
Programmable illumination control is essential for many computational microscopy techniques. Conventional light source array often arranged on a fixed grid of planar surface providing programmable sample illumination. Here, we report the development freeform illuminator that can be at arbitrary 2-dimensional or 3-dimensional (3D) structures microscopy. The designed in small form factor with dense arrangement 3D. It placed closer to angle-varied higher optical flux and smaller angular...
The applications of conventional ptychography are limited by its relatively low resolution and throughput in the visible light regime. new development coded (CP) has addressed these issues achieved highest numerical aperture for large-area optical imaging a lensless configuration. A high-quality reconstruction CP relies on precise tracking sensor's positional shifts. layer sensor, however, prevents use cross correlation analysis motion tracking. Here we derive analyze model CP. novel, to...
Garlic has been proven effective in the prevention and treatment of atherosclerosis (AS), which is widely used as a food medicine by people daily life. saponins are main active nonsulfur compounds garlic, have variety pharmacological activities against cardiovascular diseases. In this study, antiatherosclerosis properties mechanism total garlic (TSG) rats were explored. The AS animal model was established combination high‐fat feeding, intraperitoneal injection vitamin D 3, ovalbumin‐induced...
Recent advancements in ptychography have demonstrated the potential of coded (CP) for high-resolution optical imaging a lensless configuration. However, CP suffers throughput limitations due to scanning inefficiencies. To address this, we propose what believe is novel 'fly-scan' strategy utilizing two eccentric rotating mass (ERM) vibration motors high-throughput ptychographic microscopy. The intrinsic continuity technique effectively eliminates overhead typically encountered during data...