A5101944439- Acute Myocardial Infarction Research
- Coenzyme Q10 studies and effects
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Advanced battery technologies research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Emergency and Acute Care Studies
- Vitamin K Research Studies
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Free Radicals and Antioxidants
- Nitric Oxide and Endothelin Effects
- Sepsis Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Ultrasound in Clinical Applications
- Hormonal Regulation and Hypertension
- Phytochemicals and Antioxidant Activities
- Folate and B Vitamins Research
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Antioxidant Activity and Oxidative Stress
Christchurch Hospital
2012-2024
Canterbury District Health Board
2017-2022
University of Otago
2011-2021
Prevea Health
2020
National Heart Foundation of New Zealand
2018
Sorbonne Université
2017
Canterbury Health Laboratories
2010-2017
Royal Brisbane and Women's Hospital
2017
North Bristol NHS Trust
2017
Southmead Hospital
2017
Background Betaine is a major osmolyte, also important in methyl group metabolism. Concentrations of betaine, its metabolite dimethylglycine and analog trimethylamine-N-oxide (TMAO) blood are cardiovascular risk markers. Diabetes disturbs betaine: does diabetes alter associations between betaine-related measures risk? Methods Plasma samples were collected from 475 subjects four months after discharge following an acute coronary admission. Death (n = 81), secondary MI 87), admission for heart...
Patients with chest pain represent a high health care burden, but it may be possible to identify patient group low short-term risk of adverse cardiac events who are suitable for early discharge.To compare the effectiveness rapid diagnostic pathway standard-care assessment patients in usual clinical practice setting.A single-center, randomized parallel-group trial blinded outcome assessments was conducted an academic general and tertiary hospital. Participants included adults acute consistent...
Study objectiveA 2-hour accelerated diagnostic pathway based on the Thrombolysis in Myocardial Infarction score, ECG, and troponin measures (ADAPT-ADP) increased early discharge of patients with suspected acute myocardial infarction presenting to emergency department compared standard care (from 11% 19.3%). Observational studies suggest that an using Emergency Department Assessment Chest Pain Score (EDACS-ADP) may further increase this proportion. This trial tests for existence size any...
Conventionally, the assessments of endothelial function and arterial stiffness require different sets equipment, making inclusion both tests impractical for clinical epidemiological studies. Pulse wave analysis (PWA) provides useful information regarding mechanical properties tree can also be used to assess function. PWA is a simple, valid, reliable, inexpensive technique, offering great potential. The current paper will outline how measure using this technique include discussion validity...
Emergency department (ED) investigations of patients with suspected acute myocardial infarction (AMI) are time consuming, partly because the turnaround laboratory tests. Current point-of-care troponin assays shorten test times but lack precision at lower concentrations. Development greater analytical could reduce decision-making in EDs for ruling out AMI.To determine clinical accuracy AMI a single concentration measured on arrival to ED new-generation, higher assay 15-minute time.This...
Dietary interventions may have the potential to counter age-related cognitive decline. Studies demonstrated an improvement in impairment animals after supplementation with plant extracts containing flavonoids but there are few human studies. This double-blind, controlled study examined effects on performance of a 5 week Enzogenol Pinus radiata bark extract flavonoids, 42 males aged 50-65 years, body mass index >25. Participants were supplemented for weeks either plus vitamin C, or C only. A...
Our aim was to examine the effects of adjunctive coenzyme Q(10) therapy on 24-h ambulatory blood pressure (BP) in subjects with metabolic syndrome and inadequate BP control.In a randomized, double-blind, placebo-controlled 12-week crossover trial, (100 mg twice daily) or placebo administrated 30 syndrome, control (an average clinic ≥140 systolic mm Hg ≥130 for patients type 2 diabetes) while taking an unchanged, conventional antihypertensive regimen. Clinic were assessed pre- post-treatment...
Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentrations [> limit detection and < upper reference (URL)] have major cardiovascular events (MACE) all-cause mortality.A prospective 5-year follow-up recruited in the emergency department possible acute coronary syndrome (ACS) measured hs-cTnI (Abbott) hs-cTnT (Roche)...
The Manchester Acute Coronary Syndromes (MACS) rule and the Troponin-only MACS (T-MACS) risk stratify patients with suspected acute coronary syndrome (ACS). This observational study sought to validate compare T-MACS rules for assessment of myocardial infarction (AMI).Prospectively collected data from twoEDs in Australia New Zealand were analysed. Patients assigned a probability ACS based on rules, incorporating high-sensitivity troponin T, heart-type fatty acid-binding protein, ECG results...
Abstract Background Single-sample (screening) rule-out of acute myocardial infarction (AMI) with troponin requires derivation a single-test screening threshold. In data sets small event numbers, the lowest one or two concentrations (MI) patients dictate This is not optimal. We aimed to demonstrate process incorporating both real and synthetic for deriving such thresholds using novel pre-production high-precision point-of-care assay. Methods cTnI were measured from thawed plasma Troponin I...
<b>Objectives:</b> To investigate the effect of short-term statin treatment on impaired endothelium-dependent vasodilatation and haemodynamic abnormalities typically occurring in chronic heart failure (CHF). <b>Methods:</b> In a double-blind, crossover study was measured conduit resistance vessels 23 patients with non-ischaemic CHF after 6 weeks placebo 40 mg atorvastatin. The impact assessed by cardioendocrine hormones, echocardiography clinical indicators CHF. <b>Results:</b> Cholesterol...
Pulse wave analysis (PWA) has emerged as a noninvasive, valid, reliable, and widely used technique to investigate central blood pressures systemic arterial reflection (augmentation index). The gold-standard is tonometry, but this can be challenging, especially when on children. purpose of study was validate oscillometric PWA for use in Fifty-seven healthy children were recruited participation. Central peripheral augmentation index (pAIx) measured objectively using (Pulsecor R7) tonometric...
Improved ability to rapidly rule-out Acute Myocardial Infarction (AMI) in patients presenting with chest pain will promote decongestion of the Emergency Department (ED) and reduce unnecessary hospital admissions. We assessed a new commercial Heart Fatty Acid Binding Protein (H-FABP) assay for additional diagnostic value when combined cardiac troponin (using high sensitivity assay). H-FABP high-sensitivity troponins I (hs-cTnI) T (hs-cTnT) were measured samples taken on-presentation from...
The validity of the flow-mediated dilation test has been questioned due to lack normalization primary stimulus, shear stress. Shear stress can be calculated using Poiseuille's law. However, little attention given most appropriate blood velocity parameter(s) for calculating pulsatile nature flow exposes endothelial cells two distinct stimuli during cardiac cycle: a large rate change in at onset (velocity acceleration), followed by steady component. parameter typically entered into law...