A5092726937- Nanoplatforms for cancer theranostics
- Cancer, Stress, Anesthesia, and Immune Response
- Nicotinic Acetylcholine Receptors Study
- Sulfur Compounds in Biology
- Melamine detection and toxicity
- Antimicrobial Peptides and Activities
- bioluminescence and chemiluminescence research
- Redox biology and oxidative stress
- Marine Sponges and Natural Products
Jožef Stefan Institute
2022-2024
University of Ljubljana
2022-2024
Nicotine binds to nicotinic acetylcholine receptors (nAChRs) that are overexpressed in different cancer cells, promoting tumor growth and resistance chemotherapy. In this study, we aimed investigate the potential of APS7-2 APS8-2, synthetic analogs a marine sponge toxin, inhibit nicotine-mediated effects on A549 human lung cells. Our electrophysiological measurements confirmed APS8-2 act as α7 nAChR antagonists. showed no cytotoxicity while concentration-dependent The cytotoxic responses...
This study demonstrates the potential of gelatin nanoparticles as a nanodelivery system for antagonists nicotinic acetylcholine receptors (nAChRs) to improve chemotherapy efficacy and reduce off-target effects. Too often, lung cancer does not lead satisfactory results. Therefore, new approaches directed at multiple pharmacological targets in therapy are being developed. Following activation nAChRs (e.g. by nicotine), cells begin proliferate become more resistant chemotherapy-induced...

 Rak pljuč je zelo razširjena oblika raka z nizko stopnjo preživetja. Kajenje tobaka predstavlja glavni dejavnik tveganja za razvoj pljuč, saj v tobačnem dimu najdemo veliko rakotvornih snovi. Nikotin, ki sicer ni opredeljen kot rakotvoren, glavna komponenta odgovorna zasvojenost, poleg tega pa raziskave nakazujejo, da neodvisno od ostalih komponent telesu sproži različne učinke, vplivajo na in napredovanje raka. Kot agonist nikotinskih acetilholinskih receptorjev (nAChR)...