A5048217980- Nanoparticles: synthesis and applications
- Advanced materials and composites
- Powder Metallurgy Techniques and Materials
- Bone Tissue Engineering Materials
- Tuberculosis Research and Epidemiology
- Injection Molding Process and Properties
- Nanoplatforms for cancer theranostics
- Electrochemical Analysis and Applications
- Laser Material Processing Techniques
- Solid-state spectroscopy and crystallography
- Nanopore and Nanochannel Transport Studies
- Marine Sponges and Natural Products
- Advanced Nanomaterials in Catalysis
- Metallurgy and Material Forming
- Electrochemical sensors and biosensors
- Infectious Diseases and Tuberculosis
- Nicotinic Acetylcholine Receptors Study
- Cholinesterase and Neurodegenerative Diseases
- Engineering Technology and Methodologies
- Laser-induced spectroscopy and plasma
- Additive Manufacturing Materials and Processes
- Graphene and Nanomaterials Applications
- High Entropy Alloys Studies
- Inhalation and Respiratory Drug Delivery
- Air Quality and Health Impacts
University of Ljubljana
2015-2024
Biotechnical Educational Centre Ljubljana
2023
Pskov State University
1976-1983
Gorky Institute of World Literature
1977
Moscow Aviation Institute
1973
Materials with controllable multifunctional abilities for optical imaging (OI) and magnetic resonant (MRI) that also can be used in photodynamic therapy are very interesting future applications. Mesoporous TiO2 sub-micrometer particles doped gadolinium to improve photoluminescence functionality spin relaxation MRI, the added benefit of enhanced generation reactive oxygen species (ROS). The Gd-doped exhibits red emission at 637 nm is beneficial OI significantly improves MRI times, a decrease...
Dialdehyde cellulose nanofibrils (CNF) and nanocrystals (CNC) were prepared via periodate oxidation (CNF/CNC-ox) subsequently functionalized with hexamethylenediamine (HMDA) a Schiff-base reaction, resulting in partially crosslinked micro-sized (0.5-10 μm) particles (CNF/CNC-ox-HMDA) an aggregation sedimentation tendency aqueous media, as assessed by Dynamic Light Scattering Scanning Electron Microscopy. The antibacterial efficacy, aquatic vivo (to Daphnia magna) human vitro A594 lung cells)...
Hybrid collagen (Coll) bioscaffolds have emerged as a promising solution for tissue engineering (TE) and regenerative medicine. These innovative combine the beneficial properties of Coll, an important structural protein extracellular matrix, with various other biomaterials to create platforms long-term cell growth formation. The integration or cross-linking Coll increases mechanical strength stability introduces tailored biochemical physical factors that mimic natural microenvironment. This...
The pulmonary delivery of nanoparticles (NPs) is a promising approach in nanomedicine. For the efficient and safe use inhalable NPs, understanding NP interference with lung surfactant metabolism needed. Lung predominantly phospholipid substance, synthesized alveolar type II cells (ATII), where it packed special organelles, lamellar bodies (LBs). In vitro vivo studies have reported NPs impact on homeostasis, but this phenomenon has not yet been sufficiently examined. We showed that ATII-like...
The use of titanium suboxides, known as Magnéli phase TiOx, is expected to increase in the near future due their desirable properties. In order TiOx nanoparticles safely, it necessary know how interact with biological systems. this study, cytotoxicity three different was evaluated using human lung A549 cells and results were compared hazard data on two TiO₂ whose interactions have already been extensively studied. After exposed nanoparticles, metabolic activity measured by Resazurin assay,...
The irradiation of metallic surfaces by high-fluence laser pulses in an oxygen-containing atmosphere inevitably modifies the surface topography, chemistry, and wettability. These modifications significantly influence cell-surface interactions and, consequently, biocompatibility. We investigate how texturing nanosecond from a Nd:YAG (wavelength 1064 nm) influences cell adhesion morphology with aim assessing its impact on initial behaviour. Quantitative qualitative analysis osteosarcoma...
Fe-Mn alloys were produced for bioresorbable applications using the laser powder bed fusion (LPBF) process with varying parameters. The feedstock alloy LPBF was derived from conventional cast/forged bars plasma ultrasonic atomization. Additionally, a conventionally same composition investigated to compare material properties. influence of processing route and parameters on microstructure evolution, particularly formation Σ boundaries, examined correlated observed corrosion rate obtained...
We studied inflammatory and oxidative stress-related parameters cytotoxic response of human umbilical vein endothelial cells (HUVEC) to a 24 h treatment with milled particles simulating debris involved in sandblasting orthopedic implants (OI). used different abrasives (corundum-(Al2O3), corundum retrieved from removed OI (u. Al2O3), zirconia/silica composite (ZrO2/SiO2)). Morphological changes were observed by scanning electron microscopy (SEM). Concentration Interleukins IL-6 IL-1β Tumor...
Abstract The obvious benefits derived from the increasing use of engineered nano‐, new, and advanced materials associated products have to be weighed out by a governance process against their possible risks. Differences in risk perception (beliefs about potential harm) among stakeholders, particular nonscientists, low transparency underlying decision processes can lead lack support acceptance other material enabled products. To integrate scientific outcomes with stakeholders needs, this work...
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a method with high potential to visualize the distribution of elements in different samples, including variety organisms.
Nicotine binds to nicotinic acetylcholine receptors (nAChRs) that are overexpressed in different cancer cells, promoting tumor growth and resistance chemotherapy. In this study, we aimed investigate the potential of APS7-2 APS8-2, synthetic analogs a marine sponge toxin, inhibit nicotine-mediated effects on A549 human lung cells. Our electrophysiological measurements confirmed APS8-2 act as α7 nAChR antagonists. showed no cytotoxicity while concentration-dependent The cytotoxic responses...
We studied the effect of carbon black (CB) agglomerated nanomaterial on biological membranes as revealed by shapes human erythrocytes, platelets and giant phospholipid vesicles. Diluted blood was incubated with CB observed different microscopic techniques. Giant unilamellar vesicles (GUVs) created electroformation were optical microscopy. Populations erythrocytes GUVs analyzed: assessed average number distribution erythrocyte shape types (discocytes, echinocytes, stomatocytes) in test...
The applications of zinc oxide (ZnO) nanowires (NWs) in implantable wireless devices, such as diagnostic nanobiosensors and nanobiogenerators, have recently attracted enormous attention due to their unique properties. However, for these nanodevices, the biocompatibility ability control behaviour cells contact with ZnO NWs are demanded success but date, only a few contrasting results from can be found. There is need more research about nanostructures adhesion viability on surface...
In our study, plasma surface modification was employed to tailor the properties of magnesium in terms chemistry, topography, and wettability. For two sets samples, treatment involved steps using different gases (hydrogen oxygen), while one set samples treated with step only oxygen. X-ray photoelectron spectroscopy (XPS) applied determine composition, oxidation state elements, thickness oxide layer on Mg after treatments. The morphology characterised atomic force microscopy (AFM) scanning...
This study provides the first evidence that tested Magnéli TiO<sub>x</sub> are not acutely hazardous.
A retrospective cohort study of postponed outcomes surgical treatment patients with pulmonary tuberculosis was conducted; all lived in the region a high prevalence disease (the Republic Altai) and were treated during period from 2004 to 2014. All (n = 215) had indications for treatment. The main group included 111 who underwent surgery further on, while comparison 104 rejected proposed various reasons. Outcomes analyzed 3-9 years after identified, depending on clinical form type...
Poorly soluble, low (cyto)toxic particles (PSLTs) are often regarded as one group, but it is important that these can be further differentiated based on their bioactivity. Currently, there no biological endpoint groupings for inhaled nanoparticles (NPs) would allow us to subgroup PSLTs mode of action. The aim this study was group NPs cytotoxicity and by using the in vitro response endo-lysosomal system a endpoint. main cellular loading site NPs. An impaired alveolar type II cells may have...