Abstract A solution of an apparently nonimmunogenic synthetic compound, N,N‐dioctadecyl‐N',N'‐bis(2‐hydroxyethyl) propanediamine (CP‐20961), suspended in mineral oil or olive (50 mg/ml), induced acute, as well a chronic, polyarthritis when single intradermal injections (0.2 ml) were made the tail hindpaw Lewis rats. The was morphologically almost indistinguishable from classic adjuvant arthritis by Freund's complete (FCA), disease generally thought to be result delayed hyper‐sensitivity...

Early warning systems (EWS) have been proposed as a measure for controlling and preventing dengue fever outbreaks in countries where this infection is endemic. A vaccine not available has yet to reach the market due economic burden of development, introduction safety concerns. Understanding how spreads identifying risk factors will facilitate development EWS, which climate-based model still needed. An analysis was conducted examine emerging spatiotemporal hotspots at township level Taiwan,...

N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), an apparently nonimmunogenic bacterial peptidoglycan-derived small peptide, was found to induce a polyarthritis the rat similar that induced by Freund's complete adjuvant when injected in form of oil emulsion. An emulsion its isomer, N-acetylmuramyl-L-alanyl-L-isoglutamine, which unlike MDP has no immunostimulatory activity, failed disease.

Objective To examine the role of tumor necrosis factor-alpha (TNF-alpha) in producing acute inflammatory lung injury after hemorrhage and resuscitation. Design Prospective, controlled animal study. Setting Research laboratory. Subjects Male BALB/c mice. Interventions Treatment with rat antimouse monoclonal anti-TNF-alpha antibodies or control immunoglobulin G 1 hr 30% blood volume Measurements Main Results Therapy prevented posthemorrhage increases pulmonary TNF-alpha interferon-gamma...

Abstract Colchicine suppresses the development of carrageenan‐induced edema in rat with a minimum effective oral dose 6.0 mg/kg. The slope dose‐response regression line for colchicine differs significantly from that indomethacin and phenylbutazone. Based on dosages required to achieve 50% suppression this inflammation, is 0.6 1.5 times as potent phenylbutazone, respectively. In reversed passive Arthus reaction rat, suppressive activity at least 50 100 possible significance these results...

Bacterial infection often occurs after trauma and hemorrhage is believed to be a reflection of compromised host defense system. In the present study, itilect on phytohemagglutinin-induced lymphocyte proliferation was investigated. Lymphocytes obtained from rats 2 h blood withdrawal in m amount equivalent 30% total volume plowed 48% reduction proliferative response as compared cells same animal before Heeding. This depression proliferative, capacity appeared due serum factor or factors duced...

Phenylbutazone, indomethacin, sodium salicylate, gold thiomalate and chloroquine were found to suppress polymorphonuclear leukocyte phagocytosis of starch granules in vitro . The threshold concentrations these drugs at which activity was noted the system compared with plasma levels achieved man under normal therapeutic doses. It concluded that suppression phagocytic function may be involved mechanism action drugs. Indomethacin, phenylbutazone acetylsalicylic acid shown urate crystal-induced...

Background. There is ample evidence media reporting of celebrity suicides increases copycat suicides. This study had three aims: (a) to quantitatively examine with exponential modelling that predicts the suicide effect South Korean suicides; (b) investigate association between and subsequent following deaths; (c) extent in which influences increase rate decline a suicide. Methods. All during 1991–2010 Korea were included this utilising nationwide database. Fifteen celebrities selected based...

We investigated recent trends in youth suicide and their associations with societal psychological factors Taiwan.Suicide data (1971-2019) for 10-24 year olds were extracted from Taiwan's national cause-of-death files. changes rates, (gross domestic product per capita, Gini index, overall unemployment divorce rates people aged 40-59 years [i.e. the age of most 15-24 olds' parents] Internet use rates) distress indicators (youth self-harm prevalence worry-related insomnia, ideation, plan...

The degree of edema formed in the rat paw response to subplantar injection carrageenin has been shown be inhibited by agents which affect formation and resolution fibrin. Prothrombin depletion (Pival), inhibition prothrombin thrombin conversion (heparin) fibrinolysis (plasmin) all inhibit formation. action Pival is antagonized vitamin K administration, administration leads increased volumes. It believed that carrageenin-induced rat-foot edema, blood coagulation bear a close correlation,...

The development of immune response in rats directed toward EL4 cells, after the injection cells suspended a saline/oil emulsion, was enhanced by incorporation Mycobacterium into emulsion; type II collagen saline-acetic acid/oil emulsion concentrations ranging from 0.5-25 micrograms/ml had no apparent effect on response. at higher (100 micrograms and 1.0 mg/ml) significantly suppressed both humoral cell-mediated Pretreatment with maximal subarthritiogenic dose complete Freund's adjuvant...

Abstract The antimitotic effects of colchicine appear to depend upon binding the drug cytoplasmic protein that forms microtubules. Lumicolchicines (photoisomers colchicine) do not bind microtubule protein, and interfere with organization mitotic spindle. antiinflammatory may also in appropriate nondividing cells. If so, lumicolchicine would be expected have an effect. Such was case this report, which reversed passive Arthus reaction rat served as test stystem.

To investigate the reciprocal relationship between unhealthy eating behaviours and depressive symptoms from childhood to adolescence.Unhealthy were measured by frequencies of foods with excess salt, sugar or fat in past week. Depressive two weeks using a seven-item scale. Hierarchical linear growth models used analyse longitudinal associations symptoms. Time-fixed variables (sex, parents' education level household monthly income) time-varying (parents' marital status, family activities, body...

Abstract Bullying remains a pervasive issue in educational settings worldwide. This study examined the effect of teacher training and self‐efficacy on teachers' responses to school bullying with moderating age. Drawing data from 585 Taiwanese primary secondary teachers, revealed six distinct response patterns among teachers. The results underscore critical role enabling proactive bullying, highlighting that programs boost can be effective across different age groups. Furthermore, research...

<h3>Objectives:</h3> To examine the changes in nitric oxide (NO), asymmetric dimethylarginine (ADMA), symmetric (SDMA), and L-arginine levels schizophrenia during acute psychotic exacerbation bipolar disorder mania to compare those healthy controls. <h3>Methods:</h3> Thirty patients with 30 mania, who attended Psychiatry Department, Erenköy Hospital for Mental Nervous Diseases, Istanbul, Turkey, 2010. controls were included. The diagnosis was made using Structured Clinical Interview Axis I...