A5041095373- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Chronic Myeloid Leukemia Treatments
- Retinoids in leukemia and cellular processes
- Blood disorders and treatments
- Nuclear Structure and Function
- Multiple Myeloma Research and Treatments
- Platelet Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Diversity and Career in Medicine
- Bone and Joint Diseases
- Cancer Diagnosis and Treatment
- Dermatological and Skeletal Disorders
- Clinical Reasoning and Diagnostic Skills
- Parvovirus B19 Infection Studies
- Metastasis and carcinoma case studies
- PI3K/AKT/mTOR signaling in cancer
- Innovations in Medical Education
- Autoimmune and Inflammatory Disorders Research
- Advances in Oncology and Radiotherapy
- Histiocytic Disorders and Treatments
- Gender Diversity and Inequality
Einstein Healthcare Network
2024
Hospital of the University of Pennsylvania
2020-2022
University of Pennsylvania
2019-2021
University of Cincinnati
2014-2018
University of Cincinnati Medical Center
2014-2017
Vanderbilt University Medical Center
2009-2015
The Ohio State University
2011-2013
The Ohio State University Wexner Medical Center
2011
Vanderbilt University
2009
Key Points Gilteritinib induces 2 distinct marrow responses in FLT3-mutated AML: with and without differentiation. Ongoing clonal hematopoiesis is ubiquitous during gilteritinib therapy may promote genetic evolution drug resistance.
Adenosine strongly inhibits the migration of T cells from cancer patients due to reduced KCa3.1 K + channel activity.
Background: Between January 1999 and December 2008, 469 patients treated for acute myeloid leukemia (AML) were included in this single-institution study. Methods: We performed a case–control analysis to study the rate of obesity among with promyelocytic (APL) non-APL AML. Results: A total 81% APL analyzed obese compared 41.7% group ( p < 0.001). Body mass index (BMI) >30 was seen 57% 31% = 0.01). Neither nor chemotherapy dosing based on ideal body weight affected survival. Conclusions:...
Head and neck cancer (HNC) remains the sixth most common malignancy worldwide survival upon recurrence and/or metastasis poor. HNSCC has traditionally been associated with alcohol nicotine use, but more recently Human Papilloma Virus (HPV) emerged as a favorable prognostic risk factor for oropharyngeal HNSCC. However, further stratification additional biomarkers to predict patient outcome continues be essential. One candidate biomarker is DEK oncogenic protein, which was previously detected...
The coexistence of multiple myeloma and chronic myeloid leukemia in a single patient is very rare event that has been reported infrequently the literature. We report case who developed four years after his diagnosis with myeloma. Historically, no link between two malignancies identified. This synchronous existence complicates treatment plan for these patients, there lack evidence on best therapeutic approach. Our was successfully treated combination bortezomib, dexamethasone, dasatinib,...
Hematopathology fellowship education has grown in complexity as patient-centered treatment plans have come to depend on integration of clinical, morphologic, immunophenotypic, molecular, and cytogenetic variables. This is competition with the need for timely hematopathology care stewardship patient, laboratory, societal resources. Accreditation Council Graduate Medical Education Milestones provide a guidance document training, but fellows their educators are simple framework that allows...
Aberrations of ribosomal biogenesis have been implicated in several congenital bone marrow failure syndromes, such as Diamond-Blackfan anaemia, Shwachman-Diamond syndrome and Dyskeratosis Congenita. Recent studies identified haploinsufficiency RPS14 the acquired disease isolated 5q minus syndrome, a subtype myelodysplastic syndromes (MDS). However, expression various proteins comprising subunits other enzymatically involved synthesis ribosome has not explored non-5q MDS. Furthermore,...
The development of malignancy, especially lymphoma, is common after solid organ transplant. However, concurrent malignancies are rare and result in a diagnostic treatment dilemma, particularly the post-transplant setting. We present case 78-year-old male who was discovered to have high-grade lymphoproliferative disorder (PTLD) metastatic pancreatic neuroendocrine tumor (PNET) 14 years kidney He presented with abdominal pain at surgical resection found large small intestine that consistent...
TPS6109 Background: Diabetic patients with head and neck squamous cell carcinoma (HNSCC) receiving the oral hypoglycemic, metformin, demonstrated improved survival compared to those not on metformin when treated curative intent cisplatin radiation (CRT) in retrospective analyses. Pre-clinically, has been shown inhibit mTOR, a signaling pathway that regulates growth survival, commonly activated HNSCC. Pretreatment resulted decrease cavity tumors mice. Here we are prospectively investigating...
Abstract Background: Head and neck squamous cell carcinoma (HNSCC) has traditionally been associated with alcohol nicotine use, but more recently the Human Papilloma Virus (HPV) emerged as a favorable prognostic risk factor for oropharyngeal HNSCC. However, further stratification additional biomarkers to predict patient outcome continues be essential. One candidate biomarker is chromatin remodeling DEK protein, which both an auto-antigen in autoimmune diseases oncogene epithelial tissues....
e19561 Background: Results from comprehensive genomic analysis performed on aggressive B cell non-Hodgkin lymphomas (aBNHL) patient (pt) biopsies (bx) have identified mutations (mut) which may be predictive of pt survival. However, results mut (MA) aBNHL bx in clinical laboratories are not well-described. Methods: Bx diagnostic non-Burkitt obtained 7/2015-2/2021 with MA the Penn Center for Personalized Diagnostics laboratory using 3 consecutive versions lymphoma sequencing panels were...