A5021362390- Antifungal resistance and susceptibility
- Viral gastroenteritis research and epidemiology
- Fungal Infections and Studies
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Use and Resistance
- Climate Change and Health Impacts
- Antimicrobial Resistance in Staphylococcus
- Plant Pathogens and Fungal Diseases
- Escherichia coli research studies
- Hepatitis Viruses Studies and Epidemiology
- Salmonella and Campylobacter epidemiology
- COVID-19 epidemiological studies
- Enterobacteriaceae and Cronobacter Research
- Syphilis Diagnosis and Treatment
- Vibrio bacteria research studies
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- Healthcare cost, quality, practices
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Infectious Diseases and Mycology
- Travel-related health issues
- Influenza Virus Research Studies
UK Health Security Agency
2023-2024
University of Liverpool
2017-2024
Food Standards Agency
2024
Epsom and St Helier University Hospitals NHS Trust
2017-2023
Public Health England
2013-2022
National Public Health Laboratory
2020
National Health Service
2016-2018
St Helier Hospital
2017
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2017
Barts Health NHS Trust
2008-2016
In England in 2015, Shigella sonnei isolates from men who have sex with produced extended-spectrum β-lactamases and exhibited macrolide resistance. Whole-genome sequencing showed a close relationship among the isolates, which harbored plasmid that was previously identified shigellosis outbreak this population but has acquired mobile element.
To estimate UK prevalence and incidence of clinically significant carbapenemase-producing Enterobacteriaceae (CPE), to determine epidemiological characteristics, laboratory methods infection prevention control (IPC) measures in acute care facilities.A 6 month survey was undertaken November 2013-April 2014 21 sentinel laboratories as part the European Survey on Carbapenemase-Producing (EuSCAPE) project. Up 10 consecutive, non-duplicate, carbapenem-non-susceptible isolates Escherichia coli or...
Transmission of coronavirus disease 2019 (COVID-19) in healthcare settings has significant implications for patients and workers, may amplify local outbreaks, place additional burden on already stretched resources. Risk missed or late diagnosis COVID-19 was high during the UK's initial 'containment phase', because strict criteria testing. The risk remains due to asymptomatic/pre-symptomatic transmission, complicated by challenges faced with laboratory We present a case study potential...
Background Candida auris is an emerging multidrug-resistant fungal pathogen associated with bloodstream, wound and other infections, especially in critically ill patients. C. carriage persistent difficult to eradicate from the hospital environment. Aim We aimed pilot admission screening for intensive care units (ICUs) England estimate prevalence ICU population inform public health guidance. Methods Between May 2017 April 2018, we screened admissions eight adult ICUs hospitals no previous...
We sought to explore the current status of antifungal stewardship (AFS) initiatives across National Health Service (NHS) Trusts within England, challenges and barriers, as well ways improve AFS programmes.An electronic survey was sent all 155 acute NHS in England. A total 47 Trusts, corresponding 30 % English responded survey; 46 (98 %) had an antimicrobial (AMS) programme but only 5 (11 a dedicated programme. Overall, 20 (43 said they included part their AMS programmes. From those...
Excluding children with Shiga toxin-producing
A hospital outbreak of carbapenem-resistant Enterobacterales was detected by routine surveillance. Whole genome sequencing and subsequent analysis revealed a conserved promiscuous bla OXA-48 carrying plasmid as the defining factor within this outbreak. Four different species were involved in Escherichia coli ST399 accounted for 35 all 55 isolates. Comparative genomics using publicly available E. genomes showed that isolates formed unique clade. We developed mathematical model pOXA-48-like...
Background Yersiniosis is one of the most common food-borne zoonoses in Europe, but there are large variations reported incidence between different countries. Aim We aimed to describe trends and epidemiology laboratory-confirmed Yersinia infections England estimate average annual number undiagnosed enterocolitica cases, accounting for under-ascertainment. Methods analysed national surveillance data on cases by laboratories 1975 2020 enhanced questionnaires from patients diagnosed a...
A universal stool extraction method for recovery of nucleic acids (NAs) from gastrointestinal pathogens was developed to support rapid diagnostics the London 2012 Olympics. The involved mechanical disruption (bead beating) stools, followed by automated and detection using real-time PCR. This had been used extensively in Second Infectious Intestinal Disease Study (IID2) isolation NA bacteria parasites (and effective robust Cryptosporidium spp.) but not enteric viruses. To ensure this...
To assess the level of practice consistent with UK national standards for Cryptosporidium testing, an audit was performed 156 publicly funded clinical microbiology laboratories in England and Wales between August 2013 April 2014. Responses were received from 85 (54 %) laboratories. First line diagnostic methods used mainly microscopy modified Ziehl-Neelsen (mZN) or auramine phenol (AP) staining (68/85, 80 %), enzyme immunoassays (EIAs) (16/85, 19 in-house PCR (1/85, 1 %). The use EIAs more...
Purpose To compare the incidence of fungal infection after endothelial keratoplasty (EK) when donor tissue had been stored in hypothermic medium or organ culture. Methods We describe clinical features 10 cases (keratitis endophthalmitis) following EK identified at three European centres. Case definition was culture fungus a positive PCR from host cornea anterior chamber EK. A survey conducted by Eye Bank Association. The main outcome measure number which compared with Results occurred...
Brucella spp is an uncommon class 3 pathogen isolated in laboratories serving non-endemic areas. This a report of four recent cases brucellosis diagnosed at five different London laboratories, and it highlights the need to maintain high index suspicion for patients with history travel and/or consumption unpasteurised foods from endemic A protocol risk categorisation proposed, there description strategy adopted serological follow-up exposed staff use postexposure prophylaxis.