A5026069368- Algal biology and biofuel production
- Marine and coastal ecosystems
- Aquatic Ecosystems and Phytoplankton Dynamics
- ATP Synthase and ATPases Research
- Ion channel regulation and function
- American History and Culture
- Marine and coastal plant biology
- Bioactive Compounds and Antitumor Agents
- Nicotinic Acetylcholine Receptors Study
- Diatoms and Algae Research
- Receptor Mechanisms and Signaling
- Antioxidant Activity and Oxidative Stress
- American Environmental and Regional History
- Synthesis and biological activity
- Biocrusts and Microbial Ecology
- Archaeology and Natural History
- Protein Hydrolysis and Bioactive Peptides
University of Concepción
2018-2025
Ionotropic glycine receptors (GlyRs) are chloride-permeable ligand-gated ion channels expressed in the nervous system. Alterations to glycinergic inhibition and generation of dysfunctional GlyRs have been linked chronic pain, a widely prevalent disease. Positive allosteric modulators (PAMs) targeting exerted analgesic effects, motivating research on PAMs as potential pain therapies. Rationally designed tricyclic sulfonamides novel with activity. However, detailed electrophysiological studies...
Colchicine is a plant alkaloid that widely used as therapeutic agent. It accepted colchicine reduces the production of inflammatory mediators mainly by altering cytoskeleton dynamics, due to its microtubule polymerization inhibitory activity. However, other lines evidences have shown exerts direct actions on function ion channels, which are independent alterations. able modify several pentameric ligand-gated including glycine receptors (GlyRs). Previous electrophysiological studies act an...