A5043135155- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Microbial Natural Products and Biosynthesis
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Cancer-related gene regulation
- Craniofacial Disorders and Treatments
- Bioinformatics and Genomic Networks
- Fungal and yeast genetics research
- Marine Sponges and Natural Products
- Cancer-related Molecular Pathways
- Cleft Lip and Palate Research
- Cancer Genomics and Diagnostics
- Head and Neck Surgical Oncology
- Microbial Community Ecology and Physiology
- Chromatin Remodeling and Cancer
Emory University
2023-2025
Auburn University
2021
Abstract Sequencing of human patient tumors has identified recurrent missense mutations in genes encoding core histones. We report that convert histone H3 amino acid 50 from a glutamate to lysine (H3E50K) support an oncogenic phenotype. Expression H3E50K is sufficient transform cells as evidenced by increase cell migration and invasion, proliferation clonogenicity. also increases the invasive phenotype context co-occurring BRAF mutations, which are present characterized H3E50K. H3E50 lies on...
Van der Woude syndrome (VWS) is an autosomal dominant disorder characterized by lower lip pits and orofacial clefts (OFCs). With a prevalence of approximately 1 in 35,000 live births, it the most common form syndromic clefting may account for ~2% all OFCs. The majority VWS attributed to genetic variants IRF6 (~70%) or GRHL3 (~5%), leaving up 25% individuals with without molecular diagnosis. Both function transcriptional regulatory network governing differentiation periderm, single layer...
Dynamic protein post-translational methylation is essential for cellular function, highlighted by the role of in transcriptional regulation and its aberrant dysregulation diseases, including cancer. This underscores importance cataloging methylproteome. However, comprehensive analysis methylproteome remains elusive due to limitations current enrichment pipelines. Here, we employ an l-methionine analogue, ProSeMet, that chemoenzymatically converted SAM analogue ProSeAM cells vivo tag proteins...
Marine environments are home to an extensive number of microorganisms, many which remain unexplored for taxonomic novelty and functional capabilities. In this study, a slow-growing Streptomyces strain expressing unique genomic phenotypic characteristics, P38-E01 T , was described using polyphasic approach. This is part collection over 8,000 marine Actinobacteria isolates collected in the Trondheim fjord Norway by SINTEF Industry (Trondheim, Norway) Norwegian University Science Technology...
Breast cancer pathogenesis, treatment, and patient outcomes are shaped by tumor-intrinsic genomic alterations that divide breast tumors into molecular subtypes. These subtypes often dictate viable therapeutic interventions, ultimately, outcomes. However, heterogeneity of response may be a result underlying epigenetic features further stratify In this review we examine non-genetic mechanisms drive functional changes to chromatin in contribute cell tumor fitness, highlight how activity inform...
Understanding the molecular basis of cancer initiation and progression is critical in developing effective treatment strategies. Recently, mutations genes encoding histone proteins that drive oncogenesis have been identified, converting these essential into “oncohistones”. how oncohistone mutants, which are commonly single missense mutations, subvert normal function histones to requires defining functional consequences such changes. Histones present multiple copies human genome with 15 H3...
Understanding the molecular basis of cancer initiation and progression is critical to develop effective treatment strategies. Recently, mutations in genes encoding histone proteins have been identified that drive oncogenesis, converting these essential into “oncohistones”. how oncohistone mutations, which are commonly missense subvert normal function histones oncogenesis requires defining functional consequences such changes. Histones present multiple copies human genome with 15 H3 isoforms,...
Sequencing of human patient tumors has identified recurrent missense mutations in genes encoding core histones. We report that convert histone H3 amino acid 50 from a glutamate to lysine (H3E50K) support an oncogenic phenotype cells. Expression H3E50K is sufficient transform cells as evidenced by dramatic increase cell migration and invasion, statistically significant proliferation clonogenicity. also increases the invasive context co-occurring BRAF mutations, which are present characterized...