A5007715824- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- CRISPR and Genetic Engineering
- Toxoplasma gondii Research Studies
- Birth, Development, and Health
- Cancer Cells and Metastasis
- Vitamin D Research Studies
- Prenatal Screening and Diagnostics
- Advanced Glycation End Products research
- Renal and related cancers
- Cholinesterase and Neurodegenerative Diseases
- 3D Printing in Biomedical Research
- Pregnancy and preeclampsia studies
- Neurogenesis and neuroplasticity mechanisms
- Osteoarthritis Treatment and Mechanisms
- Genetics and Neurodevelopmental Disorders
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Malaria Research and Control
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
Universiti Putra Malaysia
2016-2025
Serdang Hospital
2014
University of Edinburgh
2008
Reactive oxygen species are well known for induction of oxidative stress conditions through oxidation vital biomarkers leading to cellular death via apoptosis and other process, thereby causing devastative effects on the host organs. This effect is believed be linked with pathological alterations seen in several neurodegenerative disease conditions. Many phytochemical compounds proved have robust antioxidant activities that deterred cells against cytotoxic environment, thus protect apoptotic...
Background: Combination chemotherapy of anticancer drugs is extensively being researched since it could reduce multidrug resistance and side effects as a result lower dosage each drug. In this study, we evaluated the doxorubicin-loaded (Dox-ACNP), thymoquinone-loaded (TQ-ACNP) combined doxorubicin/thymoquinone-loaded cockle shell-derived aragonite calcium carbonate nanoparticles (Dox/TQ-ACNP) on breast cancer cell line compared with their free counterpart. Methods: Cell viability using MTT...
Breast cancer remains a leading cause of death in women worldwide. Although breast therapies have greatly advanced recent years, many patients still develop tumour recurrence and metastasis, eventually succumb to the disease due chemoresistance. Citral has been reported show cytotoxic effect on various cell lines. However, potential citral specifically target drug resistant cells not yet tested, which was focus our current study.The activity first tested MDA-MB-231 vitro by MTT assay....
Breast cancer is the most commonly diagnosed and leading cause of death among females globally. The tumorigenic activities cells such as aldehyde dehydrogenase (ALDH) activity differentiation have contributed to relapse eventual mortality in breast cancer. Thus, current drug discovery research focused on targeting with ALDH their capacity form secondary tumors. Citral (3,7-dimethyl-2,6-octadienal), from lemon grass (Cymbopogoncitrates), has been previously reported a cytotoxic effect cells....
The unique variants or biomarkers of individuals help to understand the pathogenesis as well potential risk patients diabetic nephropathy (DN). aim this study was investigate association a genetic polymorphism monocyte chemoattractant protein-1 (CCL2-rs3917887), chemokine receptor 5 (CCR5-rs1799987), engulfment and cell mortality (ELMO1-rs74130), interleukin-8 (IL8-rs4073) with development DN among Malaysian type 2 diabetes mellitus (T2DM) patients. More than one thousand were examined total...
Mesenchymal stem cells (MSCs) are emerging as vehicles for anti-tumor cytotherapy; however, investigation on its efficacy to target a specific cancer cell (CSC) population in non-small lung (NSCLC) is lacking. Using assays evaluate proliferation, apoptosis, and gene expression, we investigated the of MSCs expressing tumour necrosis factor (TNF)-related apoptosis inducing ligand (MSC-TRAIL) destroy CD133+ (prominin-1 positive) NSCLC-derived CSCs. Characterization TRAIL death receptor 5 (DR5)...
Type 2 diabetes mellitus (T2DM) is associated with a high incidence of nephropathy. The aim this study was to investigate the association genetic polymorphism carnosinase ( CNDP1-D18S880 and - rs2346061 ), endothelial nitric oxide synthase NOS3-rs1799983 manganese superoxide dismutase MnSOD-rs4880 ) genes development diabetic nephropathy among Malaysian type patients. A case-control performed using 652 T2DM patients comprising 227 Malays (without = 96 131), 203 Chinese 95 108), 222 Indians...
Objective Cartilage tissue engineering has evolved as one of the therapeutic strategies for cartilage defect, which relies on a large number viable chondrocytes. Because limited availability and low chondrocytes yield from cartilage, need an improve isolation protocol maximum cells is key to achieving successful clinical constructs. This study optimizes compares different protocols cartilage. Design We employed enzymatic digestion using collagenase II trypsin. The yield, growth kinetics,...
Purpose Electrospinning is a versatile technique for producing polymeric nanofibers by the application of electrostatic forces. The electrospinnability solutions and properties electrospun can be influenced tuned process parameters. This paper aims to investigatethe influence three key parameters on tensile strength gelatin nanofibrous scaffold. Design/methodology/approach experiments were conducted with custom-built electrospinning system. Design operating variables, namely, concentration,...
Treatment of osteoarthritis (OA) is still a major clinical challenge due to the limited inherent healing capacity cartilage. Recent studies utilising stem cells suggest that therapeutic benefits these are mediated through paracrine mechanism bioactive molecules. The present study evaluates regenerative effect from human exfoliated deciduous teeth (SHED) conditioned medium (CM) on OA chondrocytes. CM was collected after SHED were cultured in serum-free (SFM) for 48 or 72 h and characterised...
The major route for Toxoplasma gondii (T. gondii) infection is through the ingestion of foods contaminated with oocyst from cat faeces. microscopic detection T. oocysts in faeces challenging, which contributes to failure detecting or differentiating it other related coccidian parasites. This study aims detect using two multicopy-target PCR assays and evaluate their genetic diversity. Cat faecal (200) samples were collected pet cats (PCs; 100) free-roaming (FRCs; within Klang Valley,...