A5007556073- Cellular transport and secretion
- Epilepsy research and treatment
- Lysosomal Storage Disorders Research
- Hereditary Neurological Disorders
- Neonatal and fetal brain pathology
- Infectious Encephalopathies and Encephalitis
- Mitochondrial Function and Pathology
- Retinal Development and Disorders
- Neonatal Respiratory Health Research
- Neurological disorders and treatments
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Cell death mechanisms and regulation
- Metabolism and Genetic Disorders
- Spinal Dysraphism and Malformations
- Bacterial Infections and Vaccines
- Pluripotent Stem Cells Research
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- ATP Synthase and ATPases Research
- Ophthalmology and Eye Disorders
- Cerebrospinal fluid and hydrocephalus
- Cellular Mechanics and Interactions
University of California, San Diego
2013-2025
Rady Children's Hospital-San Diego
2013-2025
University of California, Irvine
2017-2018
Children's Hospital of Orange County
2017
National Institute of Neurological Disorders and Stroke
2005-2009
National Institutes of Health
2005-2009
Pennsylvania State University
2008
University of California, Davis
2003
There are no US Food and Drug Administration-approved therapies for neonatal seizures. Phenobarbital phenytoin frequently fail to control concerns about the safety of seizure medications in developing brain. Levetiracetam has proven efficacy an excellent profile older patients; therefore, there is great interest its use neonates. However, randomized studies have not been performed. Our objectives were study levetiracetam compared with phenobarbital as a first-line treatment seizures.The was...
The hereditary spastic paraplegias (SPG1-33) comprise a cluster of inherited neurological disorders characterized principally by lower extremity spasticity and weakness due to length-dependent, retrograde axonopathy corticospinal motor neurons. Mutations in the gene encoding large oligomeric GTPase atlastin-1 are responsible for SPG3A, common autosomal dominant paraplegia. Here we describe family human GTPases, atlastin-2 -3 that closely related atlastin-1. Interestingly, while is...
Early-life adversity increases the risk for emotional disorders such as depression and schizophrenia. Anhedonia, thought to be a core feature of these disorders, is provoked by our naturalistic rodent model childhood (i.e., rearing pups one week in cages with limited bedding nesting, LBN). Drug use addiction are highly comorbid psychiatric featuring anhedonia, yet effects LBN on drug-seeking behavior reward stress-related circuits that underlie it remain unknown. Here we examined cocaine...
In a subset of children experiencing prolonged febrile seizures (FSs), the most common type childhood seizures, cognitive outcomes are compromised. However, underlying mechanisms unknown. Here we identified significant, enduring spatial memory problems in male rats following experimental FS (febrile status epilepticus; eFSE). Remarkably, these deficits were abolished by transient, post hoc interference with chromatin binding transcriptional repressor neuron restrictive silencing factor (NRSF...
Few studies have explored the efficacy of laser interstitial thermal therapy in pediatric epilepsy surgery. This study aims to evaluate seizure-free outcomes children and adolescents with mesial temporal lobe who underwent therapy. was a retrospective cohort performed at level 4 center. All patients had comprehensive presurgical evaluations consensus treatment decision made by multidisciplinary team. Brain magnetic resonance imaging (MRI) data were used determine lesional vs nonlesional...
Signal-transducing adaptor molecules (STAMs) are involved in growth factor and cytokine signaling as well receptor degradation, they form complexes with a number of endocytic proteins, including Hrs Eps15. In this study, we demonstrate that STAM proteins also localize prominently to early exocytic compartments profoundly regulate Golgi morphology. Upon overexpression cells, the apparatus becomes extensively fragmented dispersed, but when STAMs depleted, highly condensed. Under both...
Objective Prolonged continuous video-electroencephalography (cEEG) is recommended for neonates at risk of seizures. The cost and expertise required to provide a real-time response detected seizures often limits its utility. We hypothesised that the first hour cEEG could predict subsequent Design setting Retrospective multicentre diagnostic accuracy study. Patients 266 term seizure or with suspected Intervention was graded by expert novice interpreters as normal, mildly, moderately severely...
The endosomal sorting complex required for transport (ESCRT) machinery, including ESCRT‐III, localizes to the midbody and participates in membrane‐abscission step of cytokinesis. ESCRT‐III protein chromatin‐modifying 1B (CHMP1B) is recruitment MIT domain‐containing spastin, a microtubule‐severing enzyme, midbody. 2.5‐A structure C‐terminal tail CHMP1B with domain spastin reveals specific, high‐affinity involving noncanonical binding site between first third helices domain. structural...
INTRODUCTION: The Responsive Neurostimulation System (RNS) (NeuroPace, Mountain View) is a direct intracranial neurostimulator that FDA-approved for adults with medically refractory focal epilepsy. There currently exists limited data regarding its efficacy and safety in pediatric populations. METHODS: A retrospective chart review was conducted of patients treated the RNS between January 1, 2019 December 31, 2021 at Rady Children’s Hospital least one year. Data collected included percent...
Background: There are no FDA approved therapies for neonatal seizures. Previous studies demonstrated that phenobarbital (PHB) and phenytoin frequently fail to control concerns about the safety of seizure medications in developing brain. Levetiracetam (LEV) has proven efficacy children adults an excellent profile; therefore, there is great interest its use neonates, but randomized have not been performed.Methods: The study was a multicenter, randomized, blinded, controlled, phase IIb trial...