A5019483865- Cell Adhesion Molecules Research
- Acute Lymphoblastic Leukemia research
- Cellular Mechanics and Interactions
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Cutaneous Melanoma Detection and Management
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Urticaria and Related Conditions
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Hippo pathway signaling and YAP/TAZ
- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- PARP inhibition in cancer therapy
- Flavonoids in Medical Research
- Toxin Mechanisms and Immunotoxins
- Boron Compounds in Chemistry
- Heat shock proteins research
- Phytochemicals and Antioxidant Activities
Rudjer Boskovic Institute
2009-2024
University of Turin
2020-2023
Hungarian Academy of Sciences
2018
Johannes Gutenberg University Mainz
2018
Event Abstract Back to Notch signalling controls leukemic cells M. Antica1*, Paradzik1, Konevic1, Kunstic1, I. Kardum-Skelin2, S. Ezine3 and Matulic4 1 Rudjer Boskovic Institute, Division of MOlecular Biology, Croatia 2 University Zagreb, School Medicine, Hospital Merkur,, 3 Inserm U1020-Institut Necker Université Paris Descartes, France 4 Faculty science, biology, signaling Ikaros transcription factors are implicated in lymphocyte differentiation. Experiments from genetically manipulated...
Abstract Background Tumor progression is based on a close interaction between cancer cells and MicroEnvironment (TME). Here, we focus the role that Cancer Associated Fibroblasts (CAFs), Mesenchymal Stem Cells (MSCs) microRNAs (miRs) play in breast melanoma malignancy. Methods We used public databases to investigate miR-214 expression stroma compartment of primary human samples evaluated tumor formation dissemination following cell injections overexpressing (miR-214 over ) knock out ko mice....
Integrins form focal adhesions (FAs) at the cell edge and fibrillar (FBs) located centrally, with both serving as a link to actin cytoskeleton. Talins 1 2, key mechanosensitive proteins, are not functionally redundant. Talin1 is essential FAs, while talin2 found in large FAs FBs. KANK (kidney ankyrin repeat-containing) family proteins regulate adhesion dynamics, KANK2 binding talins localizing FBs where only present. Previously, we showed melanoma line MDA-MB-435S that within integrin αVβ5...
Integrins are heterodimeric glycoproteins that bind cells to extracellular matrix. Upon integrin clustering, multimolecular adhesion complexes (IACs) formed, creating links the cell cytoskeleton. We have previously observed decreased migration and increased sensitivity microtubule (MT) poisons, paclitaxel vincristine, in melanoma line MDA-MB-435S upon transfection with αV-specific siRNA, suggesting a link between drug sensitivity. To elucidate underlying mechanism, we determined αV-dependent...
Low survival rates of patients with metastatic triple-negative breast cancer (TNBC) and melanoma, in which current therapies are ineffective, emphasize the need for new therapeutic approaches. Integrin <i>β</i>1 appears to be a promising target when combined chemotherapy, but recent data have shown that its inactivation increases potential owing compensatory upregulation other integrin subunits. Consequently, we analyzed subunits <i>α</i>v, <i>α</i>3, or <i>α</i>4 as targets improved therapy...
Epithelial-to-mesenchymal transition (EMT) gives rise to cells with properties similar cancer stem (CSCs). Targeting the EMT program selectively eliminate CSCs is a promising way improve therapy. Salinomycin (Sal), K+/H+ ionophore, was identified as highly selective towards CSC-like cells, but its mechanism of action and selectivity remains elusive. Here, we show that Sal, monensin nigericin, disturbs function Golgi. Sal alters expression Golgi-related genes leads marked changes in Golgi...
Sirtuin 3 (Sirt3) has a promising role in cancer tumourigenesis and treatment, but there have been controversies about its as oncogene or tumour suppressor different types of cancer. Changes expression are associated with the excessive production reactive oxygen species (ROS), thus contributing to mitochondrial dysfunction age-related pathologies. Hyperoxic treatment (i.e. generator ROS) was shown support some tumourigenic properties, finally suppresses growth certain mammary carcinoma...
Estrogen (E2) is a major risk factor for the initiation and progression of malignancy in estrogen receptor (ER) positive breast cancers, whereas sirtuin 3 (Sirt3), mitochondrial NAD+-dependent deacetylase, has inhibitory effect on tumorigenic properties ER MCF-7 cancer cells. Since it unclear if this mediated through alpha (ERα) signaling pathway, study, we aimed to determine tumor-suppressive function Sirt3 cells interferes with their response E2. Although found that improves antioxidative...
Integrins are heterodimeric cell surface glycoproteins used by cells to bind the extracellular matrix (ECM) and regulate tumor proliferation, migration survival. A causative relationship between integrin expression resistance anticancer drugs has been demonstrated in different tumors, including head neck squamous carcinoma. Using a Cal27 tongue carcinoma model, we have previously that de novo of αVβ3 confers several (cisplatin, mitomycin C doxorubicin) through mechanism involving...
Adhesion between cells and the extracellular matrix (ECM) is one of prerequisites for multicellularity, motility, tissue specialization. Focal adhesions (FAs) are defined as protein complexes that mediate signals from ECM to major components cytoskeleton (microtubules, actin, intermediate filaments), their mutual communication determines a variety cellular processes. In this study, human cytoskeletal crosstalk proteins were identified by comparing datasets with experimentally determined...
&lt;p&gt;Ageing is a complex process characterised by the gradual deterioration of physiological functions and increased susceptibility to various age-related diseases. Mitochondrial dysfunction an important factor contributing ageing. Sirtuin 3 (Sirt3), mitochondrial protein essential for energy homeostasis, plays critical role in maintaining function, as loss Sirt3 reduces impairs cellular repair, which accelerates The aim this study was investigate male female mouse embryonic...