A5038095115- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease and Transplantation
- Peroxisome Proliferator-Activated Receptors
- Liver physiology and pathology
- Liver Diseases and Immunity
- Endoplasmic Reticulum Stress and Disease
- Cholesterol and Lipid Metabolism
- Mycobacterium research and diagnosis
- Inflammatory Bowel Disease
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2018-2024
CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement processes such as infection, atherosclerosis, and cancer. In macrophages, promotes an anti-inflammatory cytokine profile response to TLR activation. the present study, we questioned whether able influence human macrophage plasticity, drive its polarization toward any specific phenotype. We compared CD5L-induced phenotypic functional changes those caused by IFN/LPS,...
CD5-like (CD5L) is a soluble scavenger cysteine-rich protein that modulates inflammatory responses. We studied the involvement of CD5L in liver cancer. Immunohistochemistry (IHC) 60 hepatocellular carcinomas and 34 adjacent nontumor livers, showed staining was higher tumor than tissue (Mann-Whitney test; P = 0.0039). High correlated with elevated proliferation (Ki67, linear regression; < 0.0001) lower patient event-free survival (log-rank; 0.0185). Accordingly, expression detected cancer...
Reprogramming of immunosuppressive tumor-associated macrophages (TAMs) presents an attractive therapeutic strategy in cancer. The aim this study was to explore the role macrophage CD5L protein TAM activity and assess its potential as a target.Monoclonal antibodies (mAbs) against recombinant were raised by subcutaneous immunization BALB/c mice. Peripheral blood monocytes isolated from healthy donors stimulated with IFN/LPS, IL4, IL10, conditioned medium (CM) different cancer cell lines...
Chronic hepatic inflammation leads to liver fibrosis, which may progress cirrhosis, a condition with high morbidity. Our aim was assess the as yet unknown role of innate immunity protein CD5L in fibrosis.CD5L measured by ELISA plasma samples from cirrhotic (n = 63) and hepatitis 39) patients, healthy controls 7), immunohistochemistry tissue 12), quantitative RT-PCR mouse cell subsets isolated sorting. Recombinant (rCD5L) administered into murine model CCl4-induced damage, fibrosis immune...
Acute-on chronic liver failure (ACLF) is a syndrome that develops in patients with acutely decompensated cirrhosis (AD). It characterized by systemic hyperinflammatory state, leading to multiple organ failure. Our objective was analyze macrophage anti-inflammatory protein CD5L plasma extracellular vesicles (EVs) and assess its as yet unknown relationship lipid mediators ACLF. With this aim, EVs were purified size exclusion chromatography from the of healthy subjects (HS) (n=6) compensated...
Atherosclerosis, a process in which macrophages play key role, is accelerated diabetes. Elevated concentrations of serum-oxidized low-density lipoproteins (oxLDL) represent common feature both conditions. The main goal this study was to determine the contribution oxLDL inflammatory response exposed diabetic-mimicking THP1 cells and peripheral blood monocytes purified from non-diabetic healthy donors were cultured under normal (5 mM) or high glucose (HG) (15 with oxLDL. Then, foam cell...
Abstract Tuberculosis (TB) alone caused over a billion deaths in the last 200 years, making it one of deadliest diseases to humankind. Understanding immune mechanisms underlying protection or pathology TB is key uncover much needed innovative approaches tackle TB. The scavenger receptor cysteine‐rich molecule CD5 antigen‐like (CD5L) has been associated with TB, but whether and how CD5L shapes response during course disease remains poorly understood. Here, we show an upregulation circulation...