A5100763137- Renal cell carcinoma treatment
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Urological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Minimally Invasive Surgical Techniques
- CAR-T cell therapy research
- Surgical Simulation and Training
- Pelvic and Acetabular Injuries
- Bladder and Urothelial Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Organ Donation and Transplantation
- Hernia repair and management
- Cytokine Signaling Pathways and Interactions
- Identification and Quantification in Food
- Surgical site infection prevention
- Gastric Cancer Management and Outcomes
New York Hospital Queens
2018-2025
Presbyterian Hospital
2018-2025
NewYork–Presbyterian Hospital
2018-2025
Cornell University
2018-2025
University of Oklahoma Health Sciences Center
2022-2024
Rütgers (Germany)
2024
Rutgers, The State University of New Jersey
2024
Rutgers Sexual and Reproductive Health and Rights
2024
University of Arizona
2024
University of Oklahoma
2020-2023
The BLUS (Basic Laparoscopic Urologic Skills) consortium sought to address the construct validity of tasks and wider problem accurate, scalable affordable skill evaluation by investigating concordance 2 novel candidate methods with faculty panel scores, those automated motion metrics crowdsourcing.A surgeons (5) anonymous crowdworkers blindly reviewed a randomized sequence representative sample 24 videos (12 pegboard 12 suturing) extracted from validation study (454) using GOALS (Global...
Abstract OBJECTIVES Compare oncologic outcomes between single-segment and multi-segment resections in patients with clinical stage IA1 IA2 non-small cell lung cancer. METHODS A retrospective review (2011–2022) was conducted using a prospectively maintained database. Patients undergoing anatomical segmentectomy for IA ≤ 2 cm cancers were included. grouped into resections. excluded if they had neuroendocrine tumors, small cancer, underwent wedge resection, or lobectomy. The primary outcome...
Standardized assessment of laparoscopic skill in urology is lacking. We investigated whether the AUA (American Urological Association) BLUS (Basic Laparoscopic Urologic Skills) tasks are valid to address this need.This institutional review board approved study included 27 medical students, 42 residents, 18 fellows and 37 faculty urologists across 8 sites. Using EDGE (Electronic Data Generation Evaluation) device (Simulab, Seattle, Washington) 454 recordings were collected on peg transfer,...
Several strategies were implemented during the Covid-19 pandemic to enhance residency training and patient care. This study aims assess post-pandemic landscape of neurosurgical practice. A survey consisting 28 questions examining challenges faced in neurosurgery adaptive measures was conducted among US residents from May 2022 2023. encompassed 59 residents, predominantly male (72.9%) later years (66.1%) distributed across 25 states. Telemedicine tele-education pivotal pandemic, with virtual...
Shaikha Al-Thani, Abu Nasar, Jonathan Villena-Vargas, Sebron Harrison, Benjamin Lee, Jeffrey L. Port, Nasser Altorki, Oliver S. Chow
Historical loss of river and stream habitats due to impassable dams has contributed the severe decline many fish species. Anadromous fishes that migrate from sea freshwater streams spawn have been especially impacted as restrict these accessing ancestral spawning grounds. In 2018, Bloede Dam was removed Patapsco River near Baltimore, Maryland, restoring approximately 100 km potential habitat for migratory fish. We assessed response anadromous herring, alewife ( Alosa pseudoharengus )...
Continuous exposure of a pancreatic cancer cell line MIA PaCa-2 (MiaS) to gemcitabine resulted in the formation gemcitabine-resistant subline (MiaR). In an effort discover kinase inhibitors that inhibited MiaR growth, cells were exposed (PKIS-1 library) 384-well screening format. Three compounds (UNC10112721A, UNC10112652A, and UNC10112793A) identified growth by more than 50% (at 50 nM). Two (UNC10112721A UNC10112652A) classified as cyclin-dependent (CDK) inhibitors, whereas UNC10112793A was...
T cells are an important component of immune responses, and their function is influenced by expression inhibitory receptors. Immunization with alternative serotype adenovirus (Ad) vectors induces highly functional cell responses lower programmed death 1 (PD-1) increased boostability relative to Ad5 vectors. However, a detailed phenotypic characterization other receptors lacking, it unknown whether Ad5-induced CD8 eventually recover time. In this report, we measure the various memory markers...
2501 Background: The immunoregulatory cytokine IL-27 upregulates inhibitory immune checkpoint receptors (eg, PD-L1, TIGIT) and downregulates proinflammatory cytokines IFNγ, TNFα). SRF388 is a fully human IgG1 blocking antibody to with potential promote activation in the tumor microenvironment. A phase 1 study was conducted establish preliminary safety of identify recommended 2 doses (RP2D) suitable for monotherapy combination expansions (NCT04374877). Methods: dose-escalation (accelerated...
Abstract Restoring and sustaining anadromous fish populations is a grand challenge in the conservation of freshwater ecosystems. Alewife Alosa pseudoharengus Blueback Herring aestivalis are two closely related for which responses to passage restoration poorly known. We used targeted environmental DNA method sample 17 major tributaries Chesapeake Bay, USA, determine spatial extent habitat use during spawning season associations with watershed characteristics. To help understand passage, study...
Abstract While T-cell engaging therapies have demonstrated clear clinical benefit in the treatment of B-cell malignancies, their application to myeloid malignancies remains a challenge due limited repertoire suitable tumor specific surface antigens. Targeting HLA-restricted peptides (pHLA) derived from intracellular cancer antigens provides an opportunity explore entire proteome. CG1 (FLLPTGAEA) has been validated as HLA-A*02:01 restricted leader peptide Cathepsin G (CTSG) and is abundantly...
Objective: The aim was to determine the prevalence of metastases cervical and recurrent laryngeal cervicothoracic (CT) nodes as well survival recurrence patterns after esophagectomy with three-field lymph node dissection (TFD) in patients predominately adenocarcinoma (AC) esophagus. Background: Although TFD is commonly practiced Japan Southeast Asia for squamous cell cancer (SCC) esophagus, there are only a handful reports about its’ utilization benefit North American patients. Methods: This...
A robotic approach to general surgery procedures may provide improved postoperative outcomes compared either open or laparoscopic approaches. The role of robotics for gastroesophageal surgery, however, is still being evaluated.A review the prospective database at Valley Hospital between January 2002 and March 2014 identified 105 patients who underwent gastric esophageal resection. Patient demographics perioperative factors were studied.Over a 12 years period, median operative time distal...
2551 Background: IL-27 is an immunosuppressive cytokine, consisting of two subunits p28 and EBI3, that upregulates immune checkpoint receptors (eg, PD-L1, TIGIT) downregulates proinflammatory cytokines such as IFNγ, TNFα, IL-17. SRF388 a first-in-class, fully human IgG1 antibody to blocks the interaction between its receptor, thereby promoting activation in tumor microenvironment. The pathway activated hepatocellular carcinoma (HCC) renal cell (RCC), high circulating levels EBI3 are...
Abstract Coronary angioplasty (PTCA) of total coronary occlusion is limited by the inability guidewires and conventional dilating catheters to cross all such lesions. A new technique was therefore prospectively evaluated for PTCA these lesions using ultra‐low‐profile Probe™ “balloon on a wire” device. An intracoronary Probing Catheter™ used facilitate crossing stenosis with guidewire then deliver Into obstruction balloon dilatation. This utilized in 64 consecutive patients “absolute”...
You have accessJournal of UrologyTechnology & Instruments: Surgical Education Skills Assessment III1 Apr 2015PD19-05 HIGH-VOLUME ASSESSMENT OF SURGICAL VIDEOS VIA CROWD-SOURCING: THE BASIC LAPAROSCOPIC UROLOGIC SKILLS (BLUS) INITIATIVE Timothy Kowalewski, Robert Sweet, Ashleigh Menhadji, Averch, Geoffrey Box, Brand, Michael Fearrandino, Jihad Kaouk, Bodo Knudsen, Jamie Landman, Benjamin Lee, Bradley Schwartz, Bryan Comstock, Cory Schaffhausen, Elspeth McDougall, and Thomas Lendvay...
Abstract Background To compare the 30-day readmission rates and emergency department visit for patients who underwent robotic partial nephrectomy before after March 31st, 2020. Methods Patients were treated at University of Arizona Department Urology renal cell carcinoma from 2017–2023 reviewed. The assigned into 2 groups, Group A surgery between February 1st 2017 31st 2020, B April 2020 through May 2023. All data collected using REDCAP database. Results total 210 cases reviewed (105 in A,...