A5031517687- Asthma and respiratory diseases
- Helicobacter pylori-related gastroenterology studies
- Tryptophan and brain disorders
- Inflammatory mediators and NSAID effects
- Immune cells in cancer
- S100 Proteins and Annexins
- Estrogen and related hormone effects
- IL-33, ST2, and ILC Pathways
- Herbal Medicine Research Studies
Guangzhou University of Chinese Medicine
2022-2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2022-2024
Abstract Airway epithelial transcriptome analysis of asthma patients with different severity was used to disentangle the immune infiltration mechanisms affecting exacerbation, which may be advantageous treatment. Here we introduce various bioinformatics methods and develop two models: an OVA/CFA-induced neutrophil mouse model LPS-induced human bronchial cell damage model. Our objective is investigate molecular mechanisms, potential targets, therapeutic strategies associated severity....
Severe asthma (SA), a heterogeneous inflammatory disease characterized by immune cell infiltration, is particularly difficult to treat and manage. The airway epithelium an important tissue in regulating innate adaptive immunity, targeting epithelial may contribute improving the efficacy of therapy. Bioinformatics methods were utilized identify hub genes signaling pathways involved SA. Experiments performed determine whether these affected differences infiltration. weighted gene coexpression...