A5051818492- Asthma and respiratory diseases
- Computational Drug Discovery Methods
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Health and Mental Health
- Nutrition and Health in Aging
- Pharmacological Effects of Natural Compounds
- Respiratory and Cough-Related Research
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Health Promotion and Cardiovascular Prevention
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Mosquito-borne diseases and control
- Occupational Health and Safety Research
- Antimicrobial Peptides and Activities
- Cancer Immunotherapy and Biomarkers
- Potassium and Related Disorders
- Regulation of Appetite and Obesity
- Traditional Chinese Medicine Studies
- Viral Infections and Vectors
- Immune Cell Function and Interaction
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2017-2024
Nanfang Hospital
2024
California University of Pennsylvania
2024
Nanfang College Guangzhou
2024
Taiwan Adventist Hospital
2006-2023
National Cheng Kung University
2021-2023
Industrial Technology Research Institute
2013-2021
Hebei General Hospital
2021
Institute of Life Sciences
2021
Methodist Hospital
2020
Disease screening instruments used for secondary prevention can facilitate early determination and treatment of pathogenic factors, effectively reducing disease incidence, mortality rates, health complications. Therefore, people should be encouraged to receive examinations discovering potential factors before symptoms occur. Here, we the belief model as a foundation integrated social psychological investigated influencing examination behavioral intention among public in Taiwan. In total, 388...
Asthma patients may increase their susceptibility to SARS-CoV-2 infection and the poor prognosis of coronavirus disease 2019 (COVID-19). However, anti-COVID-19/asthma comorbidity approaches are restricted on condition. Existing evidence indicates that luteolin has antiviral, anti-inflammatory, immune regulation capabilities. We aimed evaluate possibility evolving into an ideal drug explore underlying molecular mechanisms against COVID-19/asthma comorbidity. used system pharmacology...
Long non-coding RNAs (lncRNAs) have been reported to play a critical role in the progression and metastasis of osteosarcoma. Recently, long intergenic non-protein coding RNA 689 (linc00689) has shown be involved glioma. However, precise linc00689 osteosarcoma is unknown. In this study, our data demonstrated that silencing by siRNA markedly suppressed proliferation, migration, invasion epithelial-mesenchymal transition (EMT) MG63 SAOS-2 cells. Bioinformatics analysis dual-luciferase reporter...
Zika virus (ZIKV) is a neurotropic flavivirus. The outbreak of ZIKV in 2016 created global health emergency. However, the underlying pathogenic mechanisms remain elusive. We investigated host response features vivo replication mouse model infection, by performing series transcriptomic and bioinformatic analyses mock-infected brain tissue. Tissue damage, inflammatory cells infiltration high viral were observed tissue infected mice. RNA-Seq indicated activation ferroptosis pathways. Enrichment...
To investigate the effects of varied therapeutic lifestyle programs on patients with ultrasound-diagnosed nonalcoholic fatty liver disease (NAFLD).A prospective, case-controlled study was conducted. A total 54 subjects NAFLD were subdivided into 3 groups: (1) diet plus exercise group (DPE group, n = 16); (2) (E 23); and (3) control (C 15). The DPE received a low-calorie balanced regular high-intensity stationary bicycle program for 10 weeks, while E same protocol as but without any changes...
Abstract Airway epithelial transcriptome analysis of asthma patients with different severity was used to disentangle the immune infiltration mechanisms affecting exacerbation, which may be advantageous treatment. Here we introduce various bioinformatics methods and develop two models: an OVA/CFA-induced neutrophil mouse model LPS-induced human bronchial cell damage model. Our objective is investigate molecular mechanisms, potential targets, therapeutic strategies associated severity....
The dengue virus (DENV) is a vital global public health issue. 2014 epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out comprehensive investigation aimed at identifying the transmission sources this epidemic. To analyze phylogenetics strains, envelope (E) gene sequences from 17 viral strains isolated 168 patient serum samples were sequenced phylogenetic tree was reconstructed. All serotype I including 8 genotype 9 V strains....
Objective: People suffering from coronavirus disease 2019 (COVID-19) are prone to develop pulmonary fibrosis (PF), but there is currently no definitive treatment for COVID-19/PF co-occurrence. Kaempferol with promising antiviral and anti-fibrotic effects expected become a potential COVID-19 PF comorbidities. Therefore, this study explored the targets molecular mechanisms of kaempferol against co-occurrence by bioinformatics network pharmacology. Methods: Various open-source databases Venn...
Background The antiviral activity and underlying mechanism of Patchouli alcohol remain unclear. Methods This study evaluated the cytotoxicity, optimal methods for drug administration, anti-influenza A alcohol. was also assessed via qRT-PCR, western blot, hemagglutination inhibiting (HAI) assay, hemolysis assay. Results shown to have low cytotoxicity its strongest effect associated with premixed administration. inhibited virus replication during early lifecycle stages influenza infection...
Background. This study conducted exploratory research using artificial intelligence methods. The main purpose of this is to establish an association model between metabolic syndrome and the TCM (traditional Chinese medicine) constitution characteristics individual physical examination data provide guidance for medicated diet care. Methods. Basic demographic laboratory were collected from a regional hospital health database in northern Taiwan, algorithms, such as logistic regression, Bayesian...
Limited cutaneous systemic sclerosis-associated pulmonary arterial hypertension (lcSSc-PAH) is a complex multi-system disease with high morbidity and mortality. The purpose of this study to identify the hub genes immune characteristics limited sclerosis (lcSSc) lcSSc-PAH through bioinformatics. LcSSc-PAH raw data were obtained from GEO database (GSE19617). Weighted gene Co-expression Network analysis (WGCNA) was used evaluate key modules. Then, we performed Gene Ontology (GO) terms Kyoto...
Following the global trend of reducing animal testing, various reconstructed human epidermis (RHE) models for skin irritation test (SIT) have been developed, verified, validated and included in OECD TG 439. We developed a new RHE called EPiTRI SIT method using (EPiTRI-SIT model) following guidelines. possesses morphological, biochemical physiological properties similar to with well-differentiated multilayered viable cells barrier function. The EPiTRI-SIT model was tested 20 reference...
This study aimed to assess the feasibility of an online compassion training program for nursing students and preliminarily investigate its effects on mindfulness, self-compassion, stress reduction. employed a randomized controlled trial design. Second-year from college in Guangzhou, China, were recruited as research participants August 2023. The intervention group participated 8-week via WeChat platform, comprising three stages: mindfulness (weeks 1-2), self-compassion 3-5), others 6-8)....
The unprecedented success of mRNA-lipid nanoparticles (LNPs) has highlighted their power for protein expression, but the hours-long half-life mRNA severely limits use in chronic diseases. In contrast, DNA LNPs display months-long expression and genetically encode cell type specificity, been hindered by poor (orders magnitude lower than LNPs). To overcome this, we introduce multi-stage mixing (MSM) microfluidics to control internal structure it create core-then-shell (CTS) structured LNPs....
In a working environment that is high-risk, knowledge-intensive, extremely stressful, and competitive, medical institutions have increasingly come to value the concepts of social capital health promotion. this study conducted at hospitals in Taiwan, we explored relationships among (institutional trust interpersonal trust), promotion, job satisfaction. We found institutional had significantly positive effect on both addition, trust, promotion effects Furthermore, descending order, all...
INTRODUCTION: Ilex asprella is a herbal drug commonly used to treat influenza (Flu) in Traditional Chinese Medicine. The study aims identify the distinct molecular mechanism of triterpenoid anti-influenza process against A virus H1N1. METHODS: Anti-influenza activity Asprellcosides B were evaluated by classical antiviral experiments. Structural modeling was predict target compound. Surface plasmon resonance (SPR) assay applied interaction between compound and viral proteins. RESULTS:...