A5078855705- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Plant-based Medicinal Research
- Berberine and alkaloids research
- Traffic and Road Safety
- Corporate Social Responsibility Reporting
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Traffic control and management
- Tuberculosis Research and Epidemiology
- Lung Cancer Research Studies
- Autonomous Vehicle Technology and Safety
- Environmental Sustainability in Business
- Bioinformatics and Genomic Networks
- Gastric Cancer Management and Outcomes
- Pharmacogenetics and Drug Metabolism
- HER2/EGFR in Cancer Research
- Traditional Chinese Medicine Analysis
- Sustainable Finance and Green Bonds
Guangzhou University of Chinese Medicine
2021-2025
Tongji University
2023
Shenzhen Bao'an District People's Hospital
2022
Identification of drug-target interactions (DTIs) is an important step in drug discovery and repositioning. In recent years, graph-based methods have attracted great attention show advantages on predicting potential DTIs. However, these face the problem that known DTIs are very limited expensive to obtain, which decreases generalization ability methods. Self-supervised contrastive learning independent labeled DTIs, can mitigate impact problem. Therefore, we propose a framework SHGCL-DTI for...
This study aimed to explore the effect of Jatrorrhizine on treating GR NSCLC and its possible mechanism action. Cell viability migration were performed preliminarily evaluate anti-tumor Huanglian extract inhibiting cell. Swiss Target Prediction Traditional Chinese Medicine Database, GeneCards Online Mendelian Inheritance in Man databases molecular docking carried out targets Jatrorrhizine. Western Blot was conducted detect PI3K/mTOR signaling pathway. has similar proliferation H1975 cells....
Objective: People suffering from coronavirus disease 2019 (COVID-19) are prone to develop pulmonary fibrosis (PF), but there is currently no definitive treatment for COVID-19/PF co-occurrence. Kaempferol with promising antiviral and anti-fibrotic effects expected become a potential COVID-19 PF comorbidities. Therefore, this study explored the targets molecular mechanisms of kaempferol against co-occurrence by bioinformatics network pharmacology. Methods: Various open-source databases Venn...
Abnormal fibroblast differentiation into myofibroblast is a crucial pathological mechanism of pulmonary fibrosis (PF). Super-enhancers, newly discovered cluster regulatory elements, are regarded as the regulators cell identity. We speculate that abnormal activation super-enhancers must be involved in process PF. This study aims to identify potential pathogenic super-enhancer-driven genes Differentially expressed (DEGs) PF mouse lungs were identified from GEO dataset (GDS1492). collected and...
Resistance to targeted drugs is now a challenging clinical problem in the treatment of non-small cell lung cancer (NSCLC). So far, there are no approved therapeutic for patients with disease progression after third-generation epidermal growth factor receptor-tyrosine kinase inhibitor osimertinib resistance (OR). Super-enhancers (SEs) large clusters transcriptional enhancers that drive gene expression. In this study, we aimed explore potential pathogenic SEs and their driven genes OR NSCLC....