A5046648782- Epigenetics and DNA Methylation
- Immune responses and vaccinations
- Cancer Cells and Metastasis
- Hair Growth and Disorders
- Immune cells in cancer
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Monoclonal and Polyclonal Antibodies Research
- Microtubule and mitosis dynamics
- Autoimmune Bullous Skin Diseases
- Toxin Mechanisms and Immunotoxins
- Protein Kinase Regulation and GTPase Signaling
- Pluripotent Stem Cells Research
- Cancer Mechanisms and Therapy
- Single-cell and spatial transcriptomics
- Melanoma and MAPK Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
University of Turin
2019-2024
A wealth of specialized cell populations within the skin facilitates its hair-producing, protective, sensory, and thermoregulatory functions. How vast cell-type diversity tissue architecture develops is largely unexplored. Here, with single-cell transcriptomics, spatial assignment, cell-lineage tracing, we deconstruct early embryonic mouse during key transitions from seemingly uniform developmental precursor states to a multilayered, multilineage epithelium, complex dermal identity. We...
Abstract Epithelial cells that participated in wound repair elicit a more efficient response to future injuries, which is believed be locally restricted. Here we show cell adaptation resulting from localized tissue damage has wide spatial impact at scale not previously appreciated. We demonstrate specific stem population, distant the original injury, originates long-lasting memory progenitors residing their own niche. Notably, these distal have taken part first healing but become...
Abstract The correct establishment of DNA methylation patterns during mouse early development is essential for cell fate specification. However, the molecular targets as well mechanisms that determine specificity de novo machinery differentiation are not completely elucidated. Here we show DNMT3B-dependent key developmental regulatory regions at epiblast-like cells (EpiLCs) provides an epigenetic priming ensures flawless commitment later stages. Using in vitro stem and loss function...
The main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted therapy in the management BRAF-mutated cutaneous metastatic melanoma (MM) is development therapeutic resistance. We aimed to assess this context role mTORC2, a signaling complex defined by presence essential RICTOR subunit, regarded as an oncogenic driver several tumor types, including MM.
Mammalian, or mechanistic, target of rapamycin complex 2 (mTORC2) regulates a variety vital cellular processes, and its aberrant functioning is often associated with various diseases. Rictor peculiar distinguishing mTORC2 component playing pivotal role in controlling assembly activity. Among extant organisms, conserved from unicellular eukaryotes to metazoans. We replaced two distinct, but conserved, glycine residues both the Dictyostelium piaA gene human ortholog, RICTOR The are spaced ∼50...
SUMMARY A wealth of specialized cell populations within the skin facilitates its hair producing, protective, sensory and thermoregulatory functions, but how vast cell-type diversity tissue architecture develops is largely unexplored. Here, with single-cell transcriptomics, spatial assignment cell-lineage tracing we deconstruct early embryonic mouse during key transitions from seemingly uniform developmental precursor states to a multilayered, multilineage epithelium complex dermal identity....
Abstract It is believed epithelial cells that have participated in a wound repair elicit more efficient but locally restricted response to future injuries. However here we show the cell adaptation resulting from localised tissue damage has wide spatial impact at scale not previously noticed. We demonstrate away injured site, after first injury specific stem population gives rise long term wound-memory progenitors residing their own niche of origin. Notably these taken part healing become...
By inhibiting receptor-ligand interactions in sebaceous glands, antibodies may be able to treat certain skin conditions.