A5008646883- Cardiovascular Disease and Adiposity
- Neuroinflammation and Neurodegeneration Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Biotin and Related Studies
- Advanced Fluorescence Microscopy Techniques
- Toxin Mechanisms and Immunotoxins
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Barrier Structure and Function Studies
- Cardiac electrophysiology and arrhythmias
University of Manchester
2017-2021
The cytokine interleukin-1 (IL-1) is a key contributor to neuroinflammation and brain injury, yet mechanisms by which IL-1 triggers neuronal injury remain unknown. Here we induced conditional deletion of IL-1R1 in endothelial cells, neurons blood cells assess site-specific actions model cerebral ischaemia mice. Tamoxifen treatment floxed (fl/fl) mice crossed with expressing tamoxifen-inducible Cre-recombinase under the Slco1c1 promoter resulted endothelium-specific significant decrease...
Abstract Purpose Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating vascular tone. This mediated via sympathetic nervous stimulation of PVAT by a mechanism involves noradrenaline uptake through organic cation transporter 3 (OCT3) and β -adrenoceptor-mediated adiponectin release. In obesity, autonomic dysfunction occurs, may result loss function subsequent disease. Accordingly, we have investigated abnormalities obese PVAT, the potential for...
<h3></h3> Calcium-induced calcium release drives contraction in cardiomyocytes. Located on the sarcoplasmic reticulum, ryanodine receptors (RyR) are responsible for of intracellular stores. It has recently become apparent that size and shape RyR cluster may affect functionality cluster, along with relative distance to neighbouring clusters. Here, we compared distribution RyRs atria ventricle. Isolated sheep ventricular atrial myocytes were labelled a monoclonal mouse antibody against RyR. A...
Objectives: Perivascular adipose tissue (PVAT) plays a crucial role in the modulation of vascular tone. Loss function obesity leads to an increase arterial tone, and may contribute development hypertension. Activation nitric oxide synthase (NOS) has been implicated anti-contractile effect PVAT. Accordingly, we have examined roles NOS healthy obese Methods: Electrical field stimulation profiles or noradrenaline concentration response curves were generated healthy, obese, eNOS−/− mouse...