A5017254873- Cardiovascular Disease and Adiposity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Adipose Tissue and Metabolism
- IL-33, ST2, and ILC Pathways
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Eosinophilic Esophagitis
- Heart Rate Variability and Autonomic Control
- Gastrointestinal motility and disorders
- Neuropeptides and Animal Physiology
- Eicosanoids and Hypertension Pharmacology
- Immune Cell Function and Interaction
- Cardiovascular Health and Disease Prevention
- Circadian rhythm and melatonin
- Magnesium in Health and Disease
- Atherosclerosis and Cardiovascular Diseases
- Diet and metabolism studies
- Vagus Nerve Stimulation Research
- Dietary Effects on Health
- Sodium Intake and Health
- Neuroendocrine regulation and behavior
- Pregnancy and preeclampsia studies
- Heart rate and cardiovascular health
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
University of Manchester
2015-2025
Manchester Academic Health Science Centre
2019-2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2019
University of Salford
2016-2019
University of Nevada, Reno
2012-2013
Healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on resistance arteries which is vital in regulating arterial tone. Activation of β3-adrenoceptors by sympathetic nerve-derived NA (noradrenaline) may be implicated this and stimulate the release vasodilator adiponectin from adipocytes. Understanding mechanisms responsible for determining how PVAT modify vascular vivo.Electrical field stimulation profiles healthy C57BL/6J mouse mesenteric were characterized using wire...
Abstract Purpose Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating vascular tone. This mediated via sympathetic nervous stimulation of PVAT by a mechanism involves noradrenaline uptake through organic cation transporter 3 (OCT3) and β -adrenoceptor-mediated adiponectin release. In obesity, autonomic dysfunction occurs, may result loss function subsequent disease. Accordingly, we have investigated abnormalities obese PVAT, the potential for...
In response to noradrenaline, healthy perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arterial tissue. Organ bath solution transfer experiments have demonstrated the release of PVAT-derived relaxing factors that mediate this function. The present studies were designed investigate mechanism responsible for noradrenaline-induced PVAT effect.In vitro rat contractile function was assessed using wire myography in presence and absence effects sympathomimetic...
There is evidence that vasoactive intestinal polypeptide (VIP) participates in inhibitory neuromuscular transmission (NMT) the internal anal sphincter (IAS). However, specific details concerning VIP-ergic NMT are limited, largely because of difficulties selectively blocking other neural pathways. The present study used selective P2Y1 receptor antagonist MRS2500 (1 μm) and nitric oxide synthase inhibitor N(G)-nitro-l-arginine (l-NNA; 100 to block purinergic nitrergic characterize...
Perivascular adipose tissue (PVAT) depots are metabolically active and play a major vasodilator role in healthy lean individuals. In obesity, they become inflamed eosinophil-depleted the anticontractile function is lost with development of diabetes hypertension. Moreover, eosinophil-deficient ΔdblGATA-1 mice lack PVAT exhibit Here, we have investigated effects inducing eosinophilia on health obesity. Control, obese, were administered intraperitoneal injections interleukin-33 (IL-33) for 5...
Background: Perivascular adipose tissue (PVAT) reduces vascular tone in isolated arteries vitro, however there are no studies of PVAT effects on vivo. In vitro adipocyte β3-adrenoceptors play a role function via secretion the vasodilator adiponectin. Objective: We have investigated vessel diameter vivo, and contributions Method: anaesthetised rats, sections intact mesenteric bed were visualised was recorded. Arteries stimulated with electrical field stimulation (EFS), noradrenaline (NA),...
<b><i>Background:</i></b> The mechanism of the perivascular adipose tissue (PVAT) anticontractile effect is well characterized in rodent visceral vascular beds; however, little known about PVAT function subcutaneous vessels. In addition, we have previously shown that nitric oxide synthase (NOS) dependent but not investigated roles NOS isoforms. <b><i>Objective:</i></b> Here, examined mouse gracilis artery, a fat depot, lean control and obese...
Autonomic dysregulation plays a key role in the development and progression of heart failure (HF). Vagal nerve stimulation (VNS) may be promising therapeutic approach. However, outcomes from clinical trials evaluating VNS HF have been mixed, mechanisms underlying this treatment remain poorly understood. Intermittent high-frequency (pulse width 300 µs, 30 Hz stimulation, s on, off) was used healthy sheep which established had induced by 4 weeks rapid ventricular pacing to assess (a) effects...
<h3>Introduction</h3> Perivascular adipose tissue (PVAT) has been shown by various studies to have an anti-contractile effect on the arteries it surrounds. The mechanism which PVAT exerts its is not well understood, and likely involve release of PVAT-derived relaxing factors (PVRF) such as adiponectin, that causes hyperpolarisation relaxation vascular smooth muscle. lost in obesity, therefore understanding this vital for creating novel treatments obesity-related hypertension. We propose...
Objective: Healthy perivascular adipose tissue (PVAT) exerts an anti-contractile effect on resistance arteries which is vital in regulating arterial tone. Activation of β3- adrenoceptors by the neurotransmitter, noradrenaline, may be implicated PVAT. Accordingly, we have investigated sympathetic nerve stimulation (SNS) within PVAT effect, and identified mechanisms involved. Design method: Electrical field (EFS) profiles murine mesenteric (<200 μm, +/-PVAT) were characterised using wire...
Objective: Healthy perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating blood pressure. Evidence suggests that sympathetic nervous stimulation of PVAT triggers activation adipocyte beta3-adrenoceptors, and the subsequent release vasoactive adipokine adiponectin. In obesity plasma adiponectin reduced, may result a loss function hypertension. Therefore we examined beta3-adrenoceptor effect. Design method: Body weight, pressure, glucose were measured...
Intermittent fasting is an increasingly popular method of weight loss, and has been shown to promote numerous health benefits in both obese lean humans, including improvements hypertension, diabetes, neurodegeneration cancer (reviewed by [1]). The prevalence obesity continues rise globally, with it, the hypertension [2]. However, a genetic instinct feast on food whenever it available, convenience foods delivery services, makes adherence caloric restriction difficult [3]. Pharmacotherapies...
<h3>Introduction</h3> There is considerable evidence to implicate over-activity of the sympathetic nervous system during obesity and subsequent development metabolic syndrome type 2 diabetes. It has been suggested that these conditions are dependent upon changes in small artery function. Healthy perivascular fat exerts an anti-contractile effect on circulation which lost obesity. Therefore it was decided examine effects nerve stimulation adipose tissue (PVAT) The hypothesis be tested factor...
Perivascular adipose tissue (PVAT) exerts an anti-contractile effect which is vital in regulating blood pressure. Evidence suggests that the sympathetic nervous stimulation of PVAT triggers release factors via activation beta<sub>3</sub>-adrenoceptors. There considerable evidence over-activity obesity, could result loss function, and subsequent hypertension. Therefore it was decided to examine beta<sub>3</sub>-adrenoceptor function obesity. Electrical field (EFS) profiles healthy obese mouse...
Objective: Perivascular adipose tissue (PVAT) exerts an anti-contractile effect vital to regulating blood pressure. Evidence suggests that the sympathetic nervous stimulation of PVAT triggers release factors via activation β3-adrenoceptors. Therefore it was decided examine β3-adrenoceptor function in obesity. Design and Method: Electrical field (EFS) healthy obese mouse mesenteric arteries (<200 μm, +/-PVAT) were characterised using wire myography (0.1–30 Hz, 20V, 0.2ms pulse duration, 4s...
Objective: There is considerable evidence to implicate over-activity of the sympathetic nervous system during obesity and subsequent development metabolic syndrome type 2 diabetes. It has been suggested that these conditions are dependent upon changes in small artery function II Healthy perivascular fat exerts an anti-contractile effect on circulation which lost obesity. Therefore it was decided examine effects nerve (SN) stimulation adipose tissue (PVAT) function. The hypothesis be tested...