A5000702864- Inorganic and Organometallic Chemistry
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Reactions
- Synthesis and Biological Evaluation
- Polysaccharides Composition and Applications
- Electrochemical Analysis and Applications
- Sulfur-Based Synthesis Techniques
- Thermal and Kinetic Analysis
- Essential Oils and Antimicrobial Activity
- Dendrimers and Hyperbranched Polymers
- Analytical chemistry methods development
- Gallbladder and Bile Duct Disorders
- Nanomaterials for catalytic reactions
- Chemical Synthesis and Analysis
- Radiopharmaceutical Chemistry and Applications
- Food composition and properties
- RNA Interference and Gene Delivery
- Cyclopropane Reaction Mechanisms
- Plant Pathogens and Fungal Diseases
- Chemical synthesis and alkaloids
- Analytical Chemistry and Chromatography
- Appendicitis Diagnosis and Management
- Innovative Microfluidic and Catalytic Techniques Innovation
- Medical Imaging and Pathology Studies
Gurukul Kangri Vishwavidyalaya
2014-2025
Dayanand Medical College & Hospital
2015-2023
Sant Longowal Institute of Engineering and Technology
2023
National Institution for Transforming India Aayog
2022
Punjab Agricultural University
2021
The University of Texas Southwestern Medical Center
2020
Advanced Imaging Research (United States)
2020
M.J.P. Rohilkhand University
2013-2017
Babasaheb Bhimrao Ambedkar University
2017
University of Indonesia
2017
Isoquinoline ring the changes: A novel strategy for title reaction involves ortho-haloarylalkynes which undergo sequential intermolecular addition of N heterocycles onto alkynes and subsequent intramolecular closure by arylation. The process use hydroxymethyl benzotriazole as an efficient inexpensive ligand CN CC coupling reactions.
The endo-cyclic ring closure of 1-(2-(substituted ethynyl)phenyl)-1H-pyrroles 3a-t and ethynyl)phenyl)-H-indole 4a-o mediated by Lewis acid (I(2)) under mild conditions afforded substituted 5-iodopyrrolo[1,2-a]quinolines 5a-t 5-iodoindolo[1,2-a]quinolines 6a-o in good to excellent yields. reaction shows selective C-C bond formation on the more electrophilic alkynyl carbon, resulting regioselective 6-endo-dig-cyclized product. Iodo derivatives pyrrolo- indoloquinolines allow functional group...
Polymyxins are an important class of antibiotics for the treatment bacterial infections due to multidrug resistant Gram-negative pathogens. However, their clinical utility is limited by nephrotoxicity. Here, we report a series promising next generation polymyxin nonapeptides identified on basis our understanding relationship structure with activity, cytotoxicity, and kidney compartment accumulation. We demonstrate that amine-containing N-terminal moiety specific regio- stereochemistry...
The chemical modifications of starch granules have been adopted to improve the characteristics, viz., paste clarity, resistant content, thermal stability, and so forth. modified has applied as a biopolymer in developing various preparations food, nutraceutical, pharmaceutical importance. present work is focused on phosphorylation alkali extracted mandua for improving digestion resistibility. from grains Eleusine coracana (family Poaceae) was carried out by sodium tripolyphosphate/sodium...
Essential oils extracted from different parts of some angiosperms collected either in the locality Gorakhpur or local market were assayed for their fungitoxicity against mycelial growth Aspergillus niger and Curvularia ovoidea, two storage fungi found blackgram, Vigna mungo L. The volatile wood chips Cedrus deodara (Roxb. ex Lamb) G. Don that seeds Trachyspermum ammi (L.) Sprague exhibited absolute toxicity, inhibiting both test completely. minimum inhibitory concentration (MIC) potent C. T....
Starch, being a polymer of excessive demand for the development products pharmaceutical importance, has been tremendously treated in many ways improving desired characteristics such as viscosity, paste clarity, digestibility, swelling, syneresis, and so forth. In present study, alkali-extracted starch mandua grains (Eleusine coracana; family Poaceae) was with epichlorohydrin cross-linking modified assessed solubility, water binding capacity, moisture content, degree cross-linking. The...
Abstract: Delivery of therapeutics using synthetic polymers is challenging due to toxicity, immunogenicity and impaired bioavailability following administration. However, natural are being explored as safe for their use a substitute polymers. In the past three decades, biomaterials like starches have been applied impart an imperative role in delivering therapeutics. There increased focus on finding new sources modifications. Hence, derivatization has become necessary achieve desired...
The preparative conditions for 186Re(V)DMSA and 188Re(V)DMSA (DMSA = meso-dimercaptosuccinic acid), β-emitting radiopharmaceuticals that have been shown to localize in medullary thyroid carcinoma, require modification depending on the amount of carrier rhenium chemical form medium which is supplied. Preparative are described use with carrier-free 188ReO4- saline, 186ReO4- sodium hydroxide or nitric acid. Preparation (carrier present up 2 mg per 2.5 ml reaction volume) requires a...
Ubiquitousness and increasing prevalence of dental caries makes it one the most important problems in public health. Due to high cost lack resources at primary levels prevention is better caries. Since origin related bacteria, antibacterial mainstay treatment. Lack efficacy with agents, unwanted effects resistance these agents are drawing attention scientists search for new drugs. Plants products currently gaining treatment various ailments. Although, has been exploited oral ailments this...
In the present era, 28 days of repeated-dose-toxicity study following Organization for Economic Cooperation and Development (OECD) guidelines 407 is compulsory every drug to go through phase 1 clinical trials. The increasing demand high-resistant starch containing nutraceuticals applicability modified in development targeted delivery inspired us investigate toxic profile mandua chemically cross-linked by epichlorohydrin compare it with alkali-isolated healthy adult Swiss albino mice, which...
Immer der Reihe nach: Eine neuartige Strategie für die Titelreaktion setzt auf ortho-Halogenarylalkine, eine Sequenz aus intermolekularer Addition eines N-Heterocyclus an das Alkin und intramolekularem Ringschluss durch Arylierung eingehen. Dabei findet Hydroxymethylbenzotriazol L als effizienter kostengünstiger Ligand C-N- C-C-Kupplungen Verwendung. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited...
Gene expression profiling of airway epithelial and inflammatory cells can be used to identify genes involved in environmental asthma.Airway epithelia were obtained via bronchial brush bronchoalveolar lavage (BAL) from 39 subjects comprising three phenotypic groups (nonatopic nonasthmatic, atopic asthmatic) 4 hours after instillation LPS, house dust mite antigen, saline distinct subsegmental bronchi. RNA transcript levels assessed using whole genome microarrays.Baseline (saline exposure)...