Abstract Shigellosis remains a common gastrointestinal disease mostly in children < 5 years of age developing countries. Azithromycin (AZM), macrolide, is currently the first-line treatment for shigellosis Bangladesh; ciprofloxacin (CIP) and ceftriaxone (CRO) are also used frequently. We aimed to evaluate current epidemiology antimicrobial resistance (AMR) mechanism(s) increasing macrolide Shigella Bangladesh. A total 2407 clinical isolates from 2009 2016 were studied. Over study period,...

Guillain-Barré syndrome (GBS) is an acute autoimmune peripheral neuropathy driven by autoantibodies and classical complement pathway activation. Despite treatments with intravenous immunoglobulin or plasma exchange, GBS remains characterized variability in recovery high incidence of residual disabilities. This randomized, double-blind, placebo-controlled Phase 1 trial evaluated the safety, tolerability, pharmacokinetics ANX005, a novel therapeutic targeting cascade. Patients recent-onset...

Abstract Objective The etiology of Guillain‐Barré syndrome (GBS) remains enigmatic, although genetic and environmental factors are speculated to be associated with this autoimmune condition. We investigated whether polymorphisms the haplotype structures human leukocyte antigen (HLA)‐ DQB1 gene relate response infection affect development GBS. Methods HLA‐DQB1 polymorphic alleles (*0201, *030x, *0401, *050x, *060x) were determined for 151 Bangladeshi patients GBS ethnically matched healthy...

TLR4 plays an important role in the pathogenesis of Guillain-Barré syndrome (GBS). The relationships between polymorphisms and susceptibility to GBS are poorly understood. We investigated frequency assessed association two single nucleotide (SNPs) extracellular domain (Asp299Gly Thr399Ile) with disease clinical features a Bangladeshi cohort.A total 290 subjects were included this study: 141 patients 149 unrelated healthy controls. Asp299Gly Thr399Ile genotyped using polymerase chain...

Shigella is the second leading cause of diarrheal deaths worldwide. Azithromycin (AZM) a potential treatment option for infection; however, recent emergence AZM resistance in threatens current strategy. Therefore, we conducted comprehensive whole genome-based approach to identify mechanism(s) Shigella. We performed antimicrobial susceptibility tests, polymerase chain reaction (PCR), Sanger (amplicon) sequencing, and bioinformatics approaches conduct study. Fifty-seven (38%) isolates examined...

Friedewald’s formula is the most frequently used for calculation of serum lowdensity lipoprotein cholesterol from total cholesterol, triacylglycerol and high-density cholesterol. Most laboratories use concentration 400 mg/dl as upper cut-off limit LDL but a combination to ratio may have more advantages than alone effectively. The aim this study was determine calculate using in Bangladeshi population. Serum triacylglycerol, were measured by direct method on 644 sera obtained adult subjects...

A 50-years old male presented with quadriplegia and paresthesia was diagnosed as Guillain-Barré syndrome (GBS). He found positive for severe acute respiratory coronavirus-2 (SARS-CoV-2) six weeks prior to the onset of weakness. GBS disability score 4. Electrophysiology showed inflammatory demyelinating polyradiculopathy. Anti-SARS-CoV-2 IgG positive. Immunological tests Campylobacter jejuni, Zika virus, Hepatitis E Herpes Simplex Haemophilus influanzae Mycoplasma pneumoniae were negative....

Abstract Complement activation plays a critical role in the pathogenesis of Guillain-Barré syndrome (GBS), debilitating immune-mediated neuropathy. Mannose-binding lectin (MBL) is complement factor pathway which as genetic host may influence susceptibility or severity GBS. We investigated frequency MBL2 promoter (− 550H/L and − 221X/Y) functional region (exon 1 A/O) polymorphisms their association with disease susceptibility, clinical features serum MBL among GBS patients ( n = 300) healthy...

Association of fasting plasma glucose (FPG) and post prandial (PPG) on hemoglobin glycation is still controversial. In this study we aimed to assess the influence FPG PPG in newly diagnosed never treated diabetic (NDNT-DM) subjects (T-DM) subjects. One hundred seventy seven were included study. Plasma concentrations measured by hexokinase end point technique glycated (HbA1c) levels modified cationexchange high performance liquid chromatography (HPLC). Univariate multivariate linear...

Abstract Objective Guillain‐Barré syndrome (GBS) is a rare, life‐threatening disorder of the peripheral nervous system. Immunoglobulin G Fc‐gamma receptors (FcγRs) mediate and regulate diverse effector functions are involved in pathogenesis GBS. We investigated whether FcγR polymorphisms FcγRIIa H/R131 (rs1801274), FcγRIIIa V/F158 (rs396991), FcγRIIIb NA1/NA2, their haplotype patterns affect affinity IgG‐FcγR interactivity influence GBS susceptibility severity. Methods determined 303...

Abstract Guillain‐Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in children. The objective this study was to investigate preceding infections, clinical, serological and electrophysiological characteristics outcome childhood GBS Bangladesh. We included 174 patients with aged <18 years from a prospective cohort Bangladesh between 2010 2018. performed multivariate logistic regression determine risk factors for poor outcome. Among children GBS, 74% (n = 129) were...

Friedewald’s formula (FF) is the most widely used in clinical practice to calculate low-density lipoprotein cholesterol (LDLC) from total (TC), triglyceride (TG) and high-density (HDLC). But this frequently underestimates LDLC. The aim of study was derive a regression equation (RE) abolish underestimation compare performance RE FF Bangladeshi population. derived 531 lipid profiles (equation derivation group) for calculation LDLC by multiple linear analysis. then another 952 subjects...

The emergence of multidrug-resistant (MDR) Shigella strains has impaired the efficacy first-line antimicrobials and exacerbated diarrhea-associated morbidity mortality worldwide. We report draft genome sequences 11 MDR isolated from stool specimens diarrheal patients in Bangladesh.

Campylobacter jejuni is the pathogen most commonly associated with Guillain-Barré syndrome (GBS). The present work describes draft genome sequences of 3 C. strains, BD39, BD67, and BD75, isolated from stool specimens patients jejuni-triggered GBS using Illumina technologies.

Glomerular filtration rate (GFR) is the filtrate produced by kidneys in each minute. Chronic kidney disease epidemiology (CKD-EPI) and standardized modification of diet renal (MDRD) equations are commonly used to estimate GFR. Evaluation GFR prediction regarding body mass index not available Bangladeshi population. In this study we compared estimated (eGFR) with measured creatinine clearance (CCR) lean obese subjects. Measured were 40±21 45±22 ml/min/1.73m2 groups, respectively. Compared...

Background Pain is a serious manifestation in both the acute and chronic stages of Guillain-Barre syndrome (GBS). We evaluated frequency, characteristics associated factors pain its impact on quality life (QoL) among patients with GBS. Methods enrolled 644 GBS from prospective cohort studies Bangladesh conducted between 2010 2024. Data were collected at enrolment standard follow-up time points up to 26 weeks. intensity was measured by numeric rating scale. Group differences tested using χ²...

Shigellosis remains a common gastrointestinal disease mostly in children <5 years of age developing countries. Azithromycin (AZM), macrolide, is currently the first-line treatment for shigellosis Bangladesh; ciprofloxacin (CIP) and ceftriaxone (CRO) are also used frequently. We aimed to evaluate current epidemiology antimicrobial resistance (AMR) mechanism(s) increasing macrolide

Background: Lung protective strategy in acute respiratory distress syndrome (ARDS) patients is based on low tidal volume (VT), lower end-inspiratory (plateau) pressure and higher positive end-expiratory (PEEP). But to predict body weight adjusted volume, heterogeneous pathology of the lung ARDS with different system compliance (CRS) not considered. In driving (ΔP=VT / CRS) (VT) normalized functional size. It unclear whether mechanical ventilation targeting (ΔP) more effective than (LTVV)...

Multi-drug resistance (MDR) in

Background: Diabetes mellitus is a global problem. In diabetic subjects, blood glucose levels are elevated and HbA1c formation increased. Estimation of every two to three months measure glycemic control. Blood lipid also undergo derangements in patients. Objective: We designed this cross-sectional study explore any relationship with different lipids. Materials Methods: This was done Bangladesh Institute Health Sciences General Hospital during the period January December 2013. 1253 type 2...

Nucleotide oligomerization domain (NOD) proteins are cytoplasmic receptors that play important roles in host innate immune responses to pathogens by recognizing self or non-self-molecules and have been implicated many autoimmune diseases including Guillain-Barré syndrome (GBS). The current study investigated whether NOD polymorphisms (NOD1-Glu266Lys, rs2075820, NOD2- [Arg702Trp, rs2066844 Gly908Arg, rs2066845]) contribute ligand sensing thus affect the susceptibility and/or severity of...