A5041460536- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Reconstructive Surgery and Microvascular Techniques
- Bone Tissue Engineering Materials
- Organ and Tissue Transplantation Research
The University of Tokyo
2018-2023
Uterine regeneration using decellularization scaffolds provides a novel treatment for uterine factor infertility. Decellularized require maximal removal of cellular components and minimal damage to the extracellular matrix (ECM). Among many methods, hydrostatic pressure (HP) method stands out due its low cytotoxicity superior ECM preservation compared traditional detergent methods. Conventionally, 980 MPa was utilized in HP decellularization, including first successful implementation...
Recently, many groups in the field of tissue engineering have attempted to utilize decellularized matrices for regeneration. The are known as a suitable tissue-engineered scaffold that retains original structure extracellular matrix (ECM) native well its complex vasculature. While chemical reagents such sodium dodecyl sulfate (SDS) generally selected fabricate due ease use, high hydrostatic pressure (HHP) has become powerful alternative induce decellularization without using any which...
Female infertility is estimated to affect 72.4 million or 9% of women reproductive age. There are multiple causes, such as Asherman syndrome — symptomatic intrauterine adhesions, which result from inappropriate tissue healing after damage the endometrium's basalis layer (ie surgery,
Infertility refers to the inability achieve pregnancy naturally for women. For those who are suffering from infertility due uterus malfunction, scaffold in tissue engineering approaches is believed play an important role uterine regeneration. In this research, we aim make a perfusion bioreactor model decellularization process of that was fabricated by high hydrostatic pressure. As result histology and DNA quantification assay, represented washing buffer efficiently removed cell residuals...
Infertility is the main obstacle to achieve pregnancy naturally for women. The current technique infertility treatments can not be applied pregnant women who are suffering from uterus malfunction. Tissue engineered organ promising regenerative medicine, which utilizes a scaffold play an important role tissue regeneration. In this research, we studied develop new and efficient method fabricate reconstruction by high hydrostatic pressure decellularization technique. have developed...