Benign adult familial myoclonic epilepsy (BAFME) is an autosomal disorder characterized by adult-onset cortical tremor and generalized seizures. Using whole genome sequencing, Yeetong et al. identify the causative mutation for type 4 of (BAFME4), providing insights into underlying pathogenesis.

When holding multiple items in visual working memory, representations of individual are often attracted to, or repelled from, each other. While this is empirically well-established, existing frameworks do not account for both types distortions, which appear to be opposition. Here, we demonstrate that memory distortion may confer functional benefits under different circumstances. there many remember and subjects near their capacity accurately item individually, memories become more similar...

AL’s leg was amputated resulting in phantom-limb pain (PLP). (1) When a volunteer placed her foot on or near the phantom – touching it evoked organized sensations corresponding locations phantom. (2) Mirror-visual-feedback (MVF) relieved PLP, as did, “phantom massage”. (3) Psilocybin-MVF pairing produced synergistic effects, complete elimination of and reduction paroxysmal episodes. (4) Touching volunteer’s where AL previously had external fixators, sensation nails boring through leg. Using...

Mild cognitive impairment (MCI) is an early stage of decline which could develop into dementia. An detection MCI a crucial step for timely prevention and intervention. Recent studies have developed deep learning models to detect dementia using bedside task like the classic clock drawing test (CDT). However, it remains challenge predict disease CDT data alone. Moreover, state-of-the-art techniques still face black box challenges, making questionable implement them in clinical setting.We...

This study aims to investigate functional and neurotransmitter signaling in the prefrontal-hippocampal pathway relation depression a cohort of Thai transgender women. Twenty participants completed mental health surveys imaging between January March 2024. Depression severity was measured by Patient Health Questionnaire-9 (PHQ-9) scores. Higher PHQ-9 scores were associated with lower GABA levels hippocampus, fractional amplitude low-frequency fluctuations (fALFF) dorsolateral prefrontal...

The ability to stably maintain visual information over brief delays is central healthy cognitive functioning, as the differentiate such internal representations from external inputs. One possible way achieve both via multiple concurrent mnemonic along hierarchy that differ systematically of perceptual To test this possibility, we examine orientation during perception and working memory. Human participants directly viewed, or held in mind, oriented grating patterns, similarity between fMRI...

The ability to stably maintain visual information over brief delays is central healthy cognitive functioning, as the differentiate such internal representations from external inputs. One possible way achieve both via multiple concurrent mnemonic along hierarchy that differ systematically of perceptual To test this possibility, we examine orientation during perception and working memory. Human participants directly viewed, or held in mind, oriented grating patterns, similarity between fMRI...

What happens when there are many different objects that must be maintained simultaneously in visual working memory? Prominent models focus largely on individual describing memory limits: e.g., claims we can remember only a fixed number of items, or single resource limit describes the cost holding additional items. While some acknowledge interactions between these not given prominent role most models. Here show instead items being represented independently, display is always compressed by...

Selective attention improves sensory processing of relevant information but can also impact the quality perception. For example, increases visual discrimination performance and at same time boosts apparent stimulus contrast attended relative to unattended stimuli. Can lead perceptual distortions representations? Optimal tuning accounts suggest that is biased towards "off-tuned" features maximize signal-to-noise ratio in favor target, especially when targets distractors are confusable. Here,...

The Montreal cognitive assessment (MoCA), a widely accepted screening tool for identifying patients with mild impairment (MCI), includes language fluency test of verbal functioning; its scores are based on the number unique correct words produced by taker. However, it is possible that may be counted differently various languages. This study focuses Thai as differs from English in terms word combinations. We applied automatic speech recognition (ASR) techniques to develop an assisted scoring...

Dementia is a debilitating neurological condition which impairs the cognitive function and ability to take care of oneself. The Clock Drawing Test (CDT) widely used detect dementia, but differentiating normal from borderline cases requires years clinical experience. Misclassifying mild abnormal as will delay chance investigate for potential reversible causes or slow down progression. To help address this issue, we propose an automatic CDT scoring system that adopts Attentive Pairwise...

When holding multiple items in visual working memory, representations of individual are often attracted to, or repelled from, each other. While empirically well-established, existing frameworks do not account for both types distortions, which appear to be opposition. Here, we demonstrate that memory distortion may confer functional benefits under different circumstances. there many remember and subjects near their capacity accurately item individually, memories become more similar...

Visual working memory is the mechanism supporting continued maintenance of information after sensory inputs are removed. Although capacity visual limited, memoranda that spaced farther apart on a 2-D display easier to remember, potentially because neural representations more distinct within retinotopically organized areas cortex during encoding, maintenance, or retrieval. The impact spatial separability in depth less clear, even though essential guiding interactions with objects environment....

Abstract In primates, foveal and peripheral vision have distinct neural architectures functions. However, it has been debated if selective attention operates via the same or different mechanisms across eccentricities. We tested these alternative accounts by examining effects of on steady-state visually evoked potential (SSVEP) fronto-parietal signal measured EEG from human subjects performing a sustained visuospatial task. With negligible level eye movements, both SSVEP SND exhibited...

Adaptive behaviors require the ability to resolve conflicting information caused by processing of incompatible sensory inputs. Prominent theories attention have posited that early selective helps mitigate cognitive interference facilitating task-relevant inputs and filtering out behaviorally irrelevant information. Surprisingly, many recent studies investigated role on conflict mitigation failed provide positive evidence. Here, we examined changes in selectivity visuospatial male female...

Navigating through natural environments requires localizing objects along three distinct spatial axes. Information about position the horizontal and vertical axes is available from an object's on retina, while depth axis must be inferred based second-order cues such as disparity between images cast two retinae. Past work has revealed that object in two-dimensional (2D) retinotopic space robustly represented visual cortex can predicted using a multivariate encoding model, which explicit...

The ability to stably maintain visual information over brief delays is central healthy cognitive functioning, as the differentiate such internal representations from external inputs. One possible way achieve both via multiple concurrent mnemonic along hierarchy that differ systematically of perceptual To test this possibility, we examine orientation during perception and working memory. Human participants directly viewed, or held in mind, oriented grating patterns, similarity between fMRI...

When we visualize a calendar, have vague impression of rectangular grid hovering in front. But 1% the population “see” vivid, crisp “calendar form” – e.g. an odd V shape as subject ML. We found that (1) ML could “read off”, months her calendar or alternate backward, unlike controls; (2) eyes and index finger unconsciously “tracked” reading; (3) moved with gaze tilted head; (4) after looking at contracting spiral, expanded. In second EA, was body centered access to episodic memories partially...

Traversing sensory environments requires keeping relevant information in mind while simultaneously processing new inputs. Visual is kept working memory via feature selective responses early visual cortex, but recent work had suggested that inputs wipe out this information. Here we show region-wide multiplexing abilities classic areas, with population-level response patterns cortex representing the contents of concurrently