A5101999810- Computational Drug Discovery Methods
- Synthesis and biological activity
- Structural Health Monitoring Techniques
- Tuberculosis Research and Epidemiology
- Carbohydrate Chemistry and Synthesis
- Infrastructure Maintenance and Monitoring
- Concrete Corrosion and Durability
- Antibiotic Resistance in Bacteria
- Ultrasonics and Acoustic Wave Propagation
- Diverse Scientific Research Studies
- Click Chemistry and Applications
- Cancer therapeutics and mechanisms
- Smart Parking Systems Research
- Mast cells and histamine
- Mycobacterium research and diagnosis
- Brain Tumor Detection and Classification
- Traffic Prediction and Management Techniques
- Medicinal Plant Research
- Synthesis and Reactivity of Heterocycles
- Opinion Dynamics and Social Influence
- Moringa oleifera research and applications
- Sentiment Analysis and Opinion Mining
- ATP Synthase and ATPases Research
- Wave and Wind Energy Systems
- Misinformation and Its Impacts
Amity University
2020-2025
Santokba Durlabhji Memorial hospital
2024
Indira Gandhi Delhi Technical University for Women
2024
Dr. B. R. Ambedkar National Institute of Technology Jalandhar
2024
Armed Forces Medical College
2024
Homi Bhabha National Institute
2023
Basque Center for Applied Mathematics
2023
Atomic Energy Regulatory Board
2023
Indian Institute of Technology Mandi
2020-2022
Indian Institute of Integrative Medicine
2019-2021
Background: The well-known histamine H3 receptor antagonists are based on an imidazole scaffold. However, the interaction between hepatic CYP450 and imidazole-based drugs leads to some side effects, such as low potential, physicochemical problems, etc. Therefore, another category of chemical class, benzimidazolone has been explored antihistaminic agent. Objectives: In this study, binding affinity derivatives quantitatively investigated using Dragon descriptors. Methods: models were developed...
The dynamic properties of bridges can be affected not only through damage but also from ambient uncertainty. False-positive or negative alarms may raised if environmental effects are considered in the detection algorithm. This article presents a two-step data-driven approach that incorporate temperature vibration-based and localization, provided is measured. To detect occurrence damage, prediction errors an autoassociative neural network (AANN) framework first employed as...
Alzheimer's Disease poses a significant global health burden as pervasive neurodegenerative affliction, underscoring the critical need for timely and accurate diagnosis to optimize patient care implement effective therapeutic interventions. This research delves into application of deep learning, subset artificial intelligence, potent tool automating AD classification using medical imaging data, particularly MRI. Utilizing convolutional neural networks (CNNs), Inception Net, ResNet50, VGG16,...
Bridge health monitoring has been attempted to ensure the safety of bridges in their operations, employing various measurement options like acceleration, strain, displacement, etc. The relative efficacy these measurements as a damage-sensitive response remained topic research. While acceleration traditionally used abundance, dynamic being relatively cheaper record, also holds potential replace acceleration. This study undertakes comparative investigation weighing benefits both for prompt and...
A series of 27 aryl/heteroaryl/aralkyl/aroyl piperazines were synthesized, and most these compounds reduced prostate weight mature rats by 15−47%. Three compounds, 10, 12, 18, had better activity profile (reduced 47%, 43%, 39%, respectively) than the standard drug flutamide (24% reduction). QSAR suggested structures with more cyclic branched moieties, increased topological separation O N therein, solvation connectivity index for activity. Pharmacokinetic study compound 10 at an oral dose...
Tuberculosis is an epidemic requiring new molecules with high potency and minimum side effects for its treatment. In the same respect, this review emphasises on important target enoyl-acyl carrier protein reductase or INHA crucial in completion of FAS II cycle. has retained fame since inception drug Isoniazid, as inhibitors have a long residence time hence good activity. One causes failure conventional drugs resistance towards activating genes. Here, we propose direct that do not need prior...
Summary Plasmodium yoelii infection resulted in depression of hepatic mitochondrial and microsomal mixed‐function oxidase system indices, e.g. cytochrome P‐450, b 5 phase II detoxification enzyme glutathione‐S‐transferase, while heam haemozoin registered a marked increase Swiss albino mice. Phenobarbitone (inducer) treatment showed induced levels P‐450 glutathione‐S‐transferase normal as well infected The activities were similar findings further supported by the isoenzymic profile...
ABSTRACT A promising modified sugar molecule was identified which active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis , suggesting involvement a new target. The compound demonstrated to be bactericidal, inhibited the growth M. in mice, and targeted alpha-mannosidase as competitive inhibitor with K i value 353.9 μM.
<abstract><sec> <title>Background</title> <p>Resistance to most of the antitubercular drugs has been on rising trends due misuse existing drugs. This encouraged us explore a novel scaffold that potential for quick antimicrobial action with minimum side effects. Nitrofurans have attracted their extensive biological activities, such as antibacterial and antifungal activities.</p> </sec><sec> <title>Objective</title> <p>The...
Abstract: BACKGROUND: Neurological disorders with autoimmune or inflammatory etiology pose significant challenges in terms of treatment. Therapeutic plasma exchange (TPE) has emerged as a promising adjunctive therapy for managing these conditions by removing pathogenic autoantibodies, immune complexes, and proinflammatory mediators. However, the experience TPE neurological northwestern part India is limited. METHODOLOGY: This retrospective study analyzed medical records patients who...