A5024244555- Epilepsy research and treatment
- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Reading and Literacy Development
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Language Development and Disorders
- Neuroscience and Music Perception
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Diet and metabolism studies
- Spatial Neglect and Hemispheric Dysfunction
- Hemispheric Asymmetry in Neuroscience
- Neural dynamics and brain function
- Anesthesia and Sedative Agents
- COVID-19 and Mental Health
- Memory Processes and Influences
- Natural Language Processing Techniques
- Neonatal and fetal brain pathology
- Neurological Complications and Syndromes
- Psychological Testing and Assessment
- Action Observation and Synchronization
- Empathy and Medical Education
Columbia University
2013-2025
Columbia University Irving Medical Center
2013-2024
Cleveland Clinic Lerner College of Medicine
2023
Case Western Reserve University
2023
Children's National
2023
The Neurological Institute
2006-2023
Cleveland Clinic
2018-2023
Ontario Brain Institute
2021
University Health Network
2021
Emory University
2018-2021
Abstract Event‐related brain potentials (ERPs) were recorded from young, middle‐aged, and older adults to infrequent target novel stimuli during a version of the oddball paradigm. Analyses scalp distribution suggested that shift more frontally oriented topography with increasing age was confined P3 component (as compared N1 P2) elicited by both stimuli. This first demonstration an age‐related in novelty auditory associated increase false‐alarm rate These age‐associated differences are...
[Correction Notice: An Erratum for this article was reported online in
Naming is typically assessed with visual naming tasks, yet, some patients genuine word-finding difficulty (evident in auditorily based discourse) show minimal on such measures. Evidence from cortical mapping, brain imaging and neuropsychological studies suggests that auditory measures might provide more relevant or at least, complementary information. We developed comparable tests present normative data for accuracy, response time, tip-of-the-tongue responses 100 controls. Test validity was...
Surgery for intractable temporal lobe epilepsy usually controls seizures and improves health-related quality of life (HRQOL), but some patients experience continued seizures, memory decline, or both. The relative impact these unfavorable outcomes on HRQOL has not been described.We studied seizure control, change, among 138 in the Multicenter Study Epilepsy (MSES), an ongoing, prospective study surgery outcomes. Seizure remission at 2 years 5 was prospectively determined based upon regularly...
Background and Objective: Visual object naming traditionally has been used to identify cortical areas essential for (i.e., word retrieval), investigators have found critical sites in the middle posterior temporal region most patients. Based on clinical observation, empirical findings, pathophysiology of lobe epilepsy, authors hypothesized that identified from auditory cues might also be relevant, within region, these would anatomically distinct located anterior based visual cues.
Summary Objective Extraoperative electrical stimulation mapping ( ESM ) to identify functional cortex is performed prior neurosurgical resection at epilepsy surgery programs worldwide. However, the procedure remains unstandardized, with no established clinical guidelines. We sought determine current range in practice parameters across centers. Methods developed and distributed a 31‐question survey 220 centers worldwide regarding of . Questions addressed preoperative assessment, technical...
<h3>Objective</h3> To develop and externally validate models to predict the probability of postoperative naming decline in adults following temporal lobe epilepsy surgery using easily accessible preoperative clinical predictors. <h3>Methods</h3> In this retrospective, prediction model development study, multivariable were developed a cohort 719 patients who underwent at Cleveland Clinic validated 138 one 3 centers United States (Columbia University Medical Center, Emory School Medicine,...
One challenge in dominant temporal lobe epilepsy surgery is to remove sufficient epileptogenic tissue without compromising post-operative language functioning. Pre-resection electrical stimulation mapping enables identification of areas that can be spared from resection, and also provides a unique opportunity investigate brain–language relationships. Visual object naming the gold standard for identifying ‘essential’ cortex; however, sparing visual (VN) sites has not reliably prevented...
To develop and externally validate models to predict the probability of postoperative verbal memory decline in adults after temporal lobe resection (TLR) for epilepsy using easily accessible preoperative clinical predictors.
Naming difficulty is a common symptom of left (i.e., language dominant) hemisphere epilepsy. As such, in the presurgical evaluation for drug-resistant epilepsy, which aims to localize epileptogenic region, identification naming deficit typically implicates temporal region. However, well-established finding poor those with but not right nondominant) seizures monolingual patients unreliable bilingual adults despite proficiency tested. We aimed examine performance and its relation seizure...
Naming is mediated by perisylvian cortex in the left (language-dominant) hemisphere, and thus, anterior temporal lobe resection for pharmacologically intractable epilepsy (TLE) carries risk post-operative naming decline. Interestingly, this lower patients with hippocampal sclerosis (HS) relative to those without HS (non-HS). Although hippocampus has traditionally been considered a critical structure memory, contribution naming, pattern might implicate direct involvement. On other hand, sites...
Current knowledge regarding the topography of essential language cortex is based primarily on stimulation mapping studies nonlesional epilepsy patients. We sought to determine whether space-occupying temporal lobe lesions are associated with a similar sites, as this information would be useful in surgical planning.We retrospectively compared auditory and visual naming sites 25 patients ("nonlesional") 18 ("lesional") who underwent cortical before left resection.Both groups exhibited pattern...
To develop a model to predict the probability of mood decline in adults following temporal lobe resection for treatment pharmacoresistant epilepsy.Variable selection was performed on 492 patients from Cleveland Clinic using best subsets regression. After completing variable selection, subset variables requested four epilepsy surgery centers across North America (n = 100). All data were combined final postoperative (N 592). Internal validation with bootstrap resampling performed. A clinically...
Although memory tested explicitly (e.g., recognition) is clearly deficient in the early stages of Alzheimer's disease, it less clear if implicitly similarly affected. To assess this, event-related potentials (ERPs) were recorded during a word-repetition priming paradigm, with semantic and orthographic orienting tasks, from 10 patients mild probable disease (PAD; mean age 70.6), young (24.1) older (69.8) controls. The extent by word repetition was assessed using new minus old ERP effect....
Dominant, left anteromedial temporal lobe resection (AMTLR) for seizure control carries risks to verbal episodic memory and visual object naming. Consistent with traditional thinking, decline is considered a consequence of hippocampal removal naming has been attributed lateral resection. Interestingly, recent findings suggest potential relation between integrity, which consistent studies that link the hippocampus higher level processing. Historically, evaluated using tasks; however, can also...
Summary Objective Seizure frequency represents a commonly assessed epilepsy status, but in the context of growing trend toward patient‐centered care, we examined adequacy seizure as measure status perceived by patient. Methods Between 2006 and 2008, frequency, mood, preference‐based health‐related quality life ( HRQOL ) measured with visual analog scale metric 182 adult patients sampled consecutively. Using nonparametric tests Monte Carlo computer simulations, analyzed relationship between...
Summary: Purpose: To determine whether an acetylcholinesterase inhibitor, such as donepezil, would improve memory or other cognitive/psychological functions in epilepsy patients with subjective complaints. Methods: Twenty‐three difficulty were randomized to either 3 months of donepezil (10 mg/day) placebo treatment, and then crossed over the treatment arm. Patients physicians blinded phase throughout data acquisition. Assessment cognitive functions, memory, mood, self‐rated quality life...