Fibroblast growth factor-10 (FGF10) controls survival, proliferation, and differentiation of distal-alveolar epithelial progenitor cells during lung development.To test for the protective regenerative effect Fgf10 overexpression in a bleomycin-induced mouse model pulmonary inflammation fibrosis.In SP-C-rtTA; tet(O)Fgf10 double-transgenic mice, fibrosis was induced 2-month-old transgenic mice by subcutaneous delivery bleomycin (BLM), using an osmotic minipump 1 week. Exogenous expression...

Manufacturers nowadays have access to state-of-the-art areal surface topography measurement instruments that allow investigation of at unprecedented levels detail and over a wide range scales. However, high value-added products demanding requirements, pushing technologies their limits. Therefore, deeper insight more comprehensive understanding performance behaviour current solutions is often needed. In this work, we investigate compare the results when measuring same with different,...

In this paper, we present a geometric variational algorithm for optimizing the gaits of kinematic locomoting systems. The dynamics are analogous to physics soap bubble, with system's Lie bracket supplying an "inflation pressure" that is balanced by "surface tension" term derived from Riemannian metric on shape space. We demonstrate optimizer variety system geometries (including Purcell's swimmer) and optimization criteria include maximizing displacement efficiency motion both translation...

In this paper, we present a set of geometric principles for understanding and optimizing the gaits drag-dominated kinematic locomoting systems. For systems with two shape variables, dynamics gait optimization are analogous to process by which internal pressure surface tension combine produce size soap bubble. The on curve is provided flux curvature system constraints passing through bounded gait, cost associated executing when executed at optimal (constant-power) pacing proportional its...

Isolated mechanical systems—e.g., those floating in space, free-fall, or on a frictionless surface—are able to achieve net rotation by cyclically changing their shape, even if they have no angular momentum. Similarly, swimmers immersed "perfect fluids" are use cyclic shape changes both translate and rotate the swimmer-fluid system has linear Finally, systems fully constrained direct nonholonomic constraints (e.g., passive wheels) can push against these move through world. Previous work...

The putative transcriptional regulator BPTF/FAC1 is expressed in embryonic and extraembryonic tissues of the early mouse conceptus. trophoblast lineage mammals essential to form fetal part placenta hence for growth viability embryo utero. Here, we describe a loss-of-function allele gene that causes lethality mouse. BPTF/FAC1-deficient embryos apparently normal blastocysts implant develop epiblast, visceral endoderm, ectoderm including stem cells. Subsequent development mutants, however,...

The role of Arp3 in mouse development was investigated utilizing a gene trap mutation the gene. Heterozygous WT/GT mice are normal, however, homozygous GT/GT embryos die at blastocyst stage. Earlier embryonic stages appear unaffected by mutation, probably due to maternal protein. Mutant blastocysts isolated E3.5 fail continue vitro, lack outgrowth trophoblast‐like cells culture and express reduced levels trophoblast marker Cdx2, while markers for inner cell mass be present. recessive lethal...

Locomotion for many articulated mechanical systems and animals is achieved through cyclic changes in shapes called gaits. In this paper we extend the geometric variational algorithm introduced [1] to optimize gaits kinematic with three shape variables. We then obtain optimal a variety of including four-link swimmer (an extension Purcell's swimmer). compare efficiency these systems, which highlights benefits using basis that allows continuous curvature (serpenoid swimmer) over discrete (Purcell's

In this paper we identify optimal swimming strategies for drag-dominated swimmers with a passive elastic joint. We use resistive force theory to obtain the dynamics of system. then frequency-domain analysis relate motion joint actuated couple elements geometric framework introduced in our previous work aimed at identifying useful gaits systems environments speed-maximizing and efficiency-maximizing

Differential flatness is a property which substantially reduces the difficulty involved in generating dynamically feasible trajectories for underactuated robotic systems.However, there large class of systems that are not differentially flat, and an efficient method computing does exist.In this paper we introduce weaker but more general form differential flatness, termed partial enables planning dynamic motion plans entire new systems.We provide several examples partially flat.We also extend...

Interdisciplinary research efforts have started focusing on the development of multiscale models and designer surfaces exhibiting specific properties at different scales for a purpose. With rapid evolution these new engineered microelectromechanical systems (MEMS), microfluidics, etc., there is strong need developing tools to measure characterize scales. In order obtain all meaningful details surface various required scales, one left with only option measuring using multiple technologies...

In this work, we establish key results on the existence theory for a category of initial value problems (IVPs) involving hybrid fractional integro-differential equations (HFIDEs) with $p$-Laplacian operator, utilizing modified Mittag-Leffler kernel. By employing Krasnoselskii and Banach fixed point theorems (FPTs), determine conditions required solutions. Additionally, examine Hyers-Ulam (H-U) stability problem. Lastly, present an example to confirm our theoretical results.

A key problem in robotic locomotion is finding optimal shape changes to effectively displace systems through the world. Variational techniques for gait optimization require estimates of body displacement per cycle; however, these introduce error due unincluded high order terms. In this paper, we formulate existing displacement, and describe contribution low terms estimates. We additionally magnitude higher (third) effects, identify that choice coordinate, diameter, starting phase influence...

The prevalence of childhood and adolescent obesity is increasing worldwide as well in India. Prader--Willi syndrome (PWS) one the most common causes syndromic with varied clinical manifestations across different lifespan. Herewith, we describe molecular characteristics eight PWS who were diagnosed an clinic tertiary care hospital.Clinically suspected cases screened between January 2014 2022. Detailed history examination done to look for typical features like characteristic facial appearance,...

The aim of this article is to apply some results L. Schwartz's theory radonifying maps prove existence theorems for infinite dimensional valued random variables. As a consequence, we deduce known in direction due K. Itô, Itô and M Nawata, V. Perez-Abreu C., T. Bojdecki L.G. Gorostiza

In this paper, we present a geometric variational algorithm for optimizing the gaits of kinematic locomoting systems. The dynamics are analogous to physics soap bubble, with system's Lie bracket supplying an "inflation pressure" that is balanced by "surface tension" term derived from Riemannian metric on shape space. We demonstrate optimizer variety system geometries (including Purcell's swimmer) and optimization criteria include maximizing displacement efficiency motion both translation...

Fgf10 regulates the specification and early outgrowth of vertebrate limbs. However, arrested growth limb buds neonatal death in Fgf10‐deficient embryos has precluded an understanding its putative roles later stages development. To obtain clues about these roles, we have studied localization immediate fate Fgf10‐expressing cells from Embryonic days 9.0 to 18.5, by subjecting Fgf10‐lacZ reporter immunocytochemistry with cell type‐specific markers, optical‐tomography scanning situ hybridization...