A5050830325- Microfluidic and Bio-sensing Technologies
- Microbial Inactivation Methods
- Electrical and Bioimpedance Tomography
- Microfluidic and Capillary Electrophoresis Applications
- Magnetic and Electromagnetic Effects
- Electrowetting and Microfluidic Technologies
- Cellular Mechanics and Interactions
- thermodynamics and calorimetric analyses
- 3D Printing in Biomedical Research
- Force Microscopy Techniques and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrohydrodynamics and Fluid Dynamics
- Cell Image Analysis Techniques
University of Virginia
2019
Charlottesville Medical Research
2019
University of Illinois Urbana-Champaign
2016
The University of Texas at Austin
2010-2014
The University of Texas MD Anderson Cancer Center
2010-2014
In-Q-Tel
2011
Dielectrophoresis (DEP) is an electrokinetic method that allows intrinsic dielectric properties of suspended cells to be exploited for discrimination and separation. It has emerged as a promising isolating circulation tumor (CTCs) from blood. DEP-isolation CTCs independent cell surface markers. Furthermore, isolated are viable can maintained in culture, suggesting DEP methods should more generally applicable than antibody-based approaches. The aim this article review synthesize both...
Circulating tumor cells (CTCs) are prognostic markers for the recurrence of cancer and may carry molecular information relevant to diagnosis. Dielectrophoresis (DEP) has been proposed as a marker-independent approach isolating CTCs from blood shown be broadly applicable different types cancers. However, existing batch-mode microfluidic DEP methods have unable process 10 ml clinical specimens rapidly enough. To achieve required processing rates 10(6) nucleated cells/min, we describe...
Although dielectrophoresis ( DEP ) has great potential for addressing clinical cell isolation problems based on dielectric differences, a biological basis predicting the behavior of cells been lacking. Here, properties NCI ‐60 panel tumor types have measured by dielectrophoretic field‐flow fractionation, correlated with exterior morphologies during growth, and compared morphological characteristics subpopulations peripheral blood. In agreement earlier findings, total capacitance varied both...
The number of circulating tumor cells (CTCs) found in blood is known to be a prognostic marker for recurrence primary tumors, however, most current methods isolating CTCs rely on cell surface markers that are not universally expressed by CTCs. Dielectrophoresis (DEP) can discriminate and manipulate cancer microfluidic systems has been proposed as molecular marker-independent approach from blood. To investigate the potential applicability DEP different types, dielectric density properties...
The first microfluidic device for co-culture of two tissue slices under continuous recirculating flow was used to model tumor-induced immunosuppression.
Journal Article Dynamic physical properties of dissociated tumor cells revealed by dielectrophoretic field-flow fractionation Get access Sangjo Shim, Shim Department Imaging Physics Unit 951, The University Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030, USA. Fax: +1 713 834 6103; Tel: 6142Department Biomedical Engineering, at Austin, 1 Station, C0800, TX78712, USA Search for other works this author on: Oxford Academic Google Scholar Peter Gascoyne, Gascoyne 6142...
In this paper, frequency response (dynamic compression and recovery) is suggested as a new physical marker to differentiate between breast cancer cells (MCF7) normal (MCF10A). A single cell placed on the laminated piezoelectric actuator piezoresistive microcantilever upper surface of at specified preload displacement (or an equivalent force). The excites in sinusoidal fashion its dynamic deformation then evaluated from converted by measuring voltage output through piezoresistor...