A5045165212- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Catalytic Cross-Coupling Reactions
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Nicotinic Acetylcholine Receptors Study
- Asymmetric Hydrogenation and Catalysis
- Chemical synthesis and alkaloids
- bioluminescence and chemiluminescence research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Thyroid Disorders and Treatments
- Photoreceptor and optogenetics research
- Synthesis and Catalytic Reactions
- Neuroscience and Neuropharmacology Research
- Marine Toxins and Detection Methods
- Cyclopropane Reaction Mechanisms
- Mass Spectrometry Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Ophthalmology and Eye Disorders
- Oxidative Organic Chemistry Reactions
- Amino Acid Enzymes and Metabolism
- Coordination Chemistry and Organometallics
- Neuropeptides and Animal Physiology
University of Amsterdam
1997-2001
Stockholm University
2000
Leiden University
1995-1998
By choosing the right substituents either highly functionalized unusual four-membered ring amino acids or isomeric pipecolic acid derivatives are obtained in enantiomerically pure form. Starting material is a linear allene-containing that has been resolved via biocatalysis.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWater Structural Changes at the Proton Uptake Site (the Thr46-Asp96 Domain) in L Intermediate of BacteriorhodopsinYoichi Yamazaki, Minoru Hatanaka, Hideki Kandori, Jun Sasaki, Willem F. Jan Karstens, Raap, Johan Lugtenburg, Marina Bizounok, Judith Herzfeld, and Cite this: Biochemistry 1995, 34, 21, 7088–7093Publication Date (Print):May 30, 1995Publication History Published online1 May 2002Published inissue 30...
Background: Treatment of Graves' hyperthyroidism (GH) and orbitopathy (GO) is far from adequate, hence, new substances that specifically target the autoantigens in GH/GO are warranted. This study determined preclinical vitro efficacy SYD5115, a novel low-molecular-weight compound inhibits thyrotropin receptor (TSH-R). Methods: The TSH-R inhibiting capability SYD5115 was tested through stimulation wild-type chimeric expressed Chinese hamster ovary (CHO) cells using two functional (stimulatory...
A route for the synthesis of enantiopure allene-substituted lactams has been developed. The key-step involves copper(I) mediated SN2′ substitution propargylic tosylates by a (S)-pyroglutamic acid derived organozinc reagent. Pd-catalysed reaction these allenes with iodobenzene afforded bicyclic enamides. Furthermore unexpected formation an interesting diene is reported.
Abstract [3‐ 18 O]‐L‐serine, 13 C]‐L‐serine, O]‐L‐threonine, [3,4‐ C 2 ]‐L‐threonine and H]‐L‐threonine are prepared from simple commercially available, isotopically enriched starting materials like H O, [ C]‐paraformaldehyde, ]‐acetaldehyde [1‐ H]‐acetaldehyde. The introduction of the side chain is based on reaction anion bislactimether cyclo‐(D‐Val‐Gly) with a suitable reagent. For serine this labelled benzylchloromethylether, whereas for threonine acetaldehyde used in combination...
The thyrotropin receptor (TSH-R) regulates the thyroid gland and is normally activated by thyrotropin. In patients with Graves' disease, TSH-R also stimulated stimulatory autoantibodies leading to hyperthyroidism. this paper, we describe discovery of SYD5115 (67), a novel small molecule antagonist nanomolar potency. blocks stimulating antibody induced synthesis hormone thyroxine (T4) in vivo, after single oral dose. During optimization, several issues had be addressed such as low metabolic...
The behavior of threonine residues in the bacteriorhodopsin (bR) photocycle has been investigated by Fourier transform infrared difference spectroscopy. L-Threonine labeled at hydroxyl group with 18O (L-[3-(18)O]threonine) was incorporated into bR and bR-->M FTIR spectra measured. Bands are assigned to vibrational modes on basis induced isotope frequency shifts normal mode calculations. In 3500 cm-1 region, a negative band is OH stretch threonine. 1125 mixed CH3 rock/CO mode. both these...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”