A5004122002- Thyroid Disorders and Treatments
- Ophthalmology and Eye Disorders
- Mechanical Circulatory Support Devices
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Arrhythmias and Treatments
- Craniofacial Disorders and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Vascular Malformations and Hemangiomas
- Autopsy Techniques and Outcomes
- Diabetes Management and Education
- Cardiac, Anesthesia and Surgical Outcomes
- Orthodontics and Dentofacial Orthopedics
- Blood groups and transfusion
- Infective Endocarditis Diagnosis and Management
- Scoliosis diagnosis and treatment
- Muscle metabolism and nutrition
- Vascular Malformations Diagnosis and Treatment
- Mindfulness and Compassion Interventions
- Intracranial Aneurysms: Treatment and Complications
- Dietary Effects on Health
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Radiopharmaceutical Chemistry and Applications
University Medical Center of the Johannes Gutenberg University Mainz
2021-2024
Johannes Gutenberg University Mainz
2021-2024
Cape Fear Valley Medical Center
2021
Michigan United
2017
Trinity Health Oakland Hospital
2017
SRM Dental College
2014
Memorial Regional Hospital
2012
University of Oklahoma
2012
Abstract Objective The ‘Detroit Cardiogenic Shock Initiative’ is a single‐arm, multicenter study to assess the feasibility of early mechanical circulatory support (MCS) in patients who present with acute myocardial infarction complicated by cardiogenic shock (AMICS) undergo percutaneous coronary intervention. Methods Between July 2016 and February 2017, 4 metro Detroit sites participated study. centers agreed treat AMICS using mutually agreed‐upon protocol emphasizing invasive hemodynamic...
Background: Treatment of Graves' hyperthyroidism (GH) and orbitopathy (GO) is far from adequate, hence, new substances that specifically target the autoantigens in GH/GO are warranted. This study determined preclinical vitro efficacy SYD5115, a novel low-molecular-weight compound inhibits thyrotropin receptor (TSH-R). Methods: The TSH-R inhibiting capability SYD5115 was tested through stimulation wild-type chimeric expressed Chinese hamster ovary (CHO) cells using two functional (stimulatory...
Background: Early repolarization (ER) is associated with increased mortality in the general population. We sought to develop and validate a prognostic index (PI) of patients ER. Methods: identified 852 consecutive (mean age 49 ± 12 years) ER (J‐point elevation ≥0.1 mV inferior or lateral leads), from VA electronic electrocardiogram (ECG) database. A random sample age‐matched normal ECG was used as control (n = 257). The initial cohort randomly split into derivation validation (2/3 1/3...
Arteriovenous malformation of both the maxilla and mandible in a pediatric patient is very rare phenomenon that carries with it high mortality rate. malformations, sometimes known as simple vascular tumors, can be present from birth or acquired over time due to trauma, surgery, any kind manipulation an area body.
Background Thyroid-blocking immunoglobulins (TBI) are present in 10%–15% of patients with autoimmune thyroid disease (AITD). TBI affect function. The analytical performance a novel bioassay was evaluated. Methods Sera from AITD were tested cell-based reporter (Thyretain ® ) the expression luciferase transgene as readout and new “Turbo™” based on cyclic AMP-activated luciferase. All samples also run two TSH-R binding immunoassays. A Passing–Bablok regression, Bland–Altman plot, user/lot...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
George, Augustine MS; Lee, Seong K. MD, FACS; Carrillo, Eddy H. FACS Author Information
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Disclosure: G.J. Kahaly: None. A. George: L. Steiner: T. Weirauch: J. Henseling: Frommer: Wolf: Background & aims: Treatment of both Graves’ hyperthyroidism (GH) and orbitopathy (GO) is still far from adequate, hence new therapeutic modalities, which specifically target the autoantigens in GH/GO, are warranted. This study determined preclinical vitro efficacy SYD5115, a novel thyrotropin receptor (TSH-R) antagonist. Methods: SYD5115 nanomolar potent low molecular weight TSH-R...
Abstract Disclosure: G.J. Kahaly: None. M.A. Lupo: A.T. Bossowski: L. Frommer: B. Hatun: A. George: J. Wolf: Background: Autoantibody mimicry of hormone action at the thyrotropin receptor (TSH-R) and aberrant signaling TSH-R by autoantibodies (TSH-R-Ab) causes autoimmune thyroid disease (AITD), hyperthyroidism hypothyroidism, both which affect millions patients worldwide. In this multicenter, single blind study, specificity, sensitivity performance a novel bioassay for stimulatory TSH-R-Ab...
Abstract Disclosure: A. George: None. A.T. Bossowski: B. Hatun: J. König: M.A. Lupo: L. Frommer: Wolf: G.J. Kahaly: Background: Thyrotropin receptor (TSH-R) blocking autoantibodies (TBAb) are present in 10-15% of patients with autoimmune thyroid disease (AITD). TBAb functional, impact function, and clinically relevant. This multicenter study compares, a large collective AITD subjects, the sensitivity specificity four immunoassays for measurement introduces novel ultra-rapid bioassay....