A5082842908- melanin and skin pigmentation
- Cannabis and Cannabinoid Research
- Antimicrobial agents and applications
- Immune Response and Inflammation
- biodegradable polymer synthesis and properties
- Natural product bioactivities and synthesis
- Bone Metabolism and Diseases
- Electrospun Nanofibers in Biomedical Applications
- Olfactory and Sensory Function Studies
- Curcumin's Biomedical Applications
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Vitamin C and Antioxidants Research
- Pharmacological Effects of Medicinal Plants
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Skin Protection and Aging
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
Sapienza University of Rome
2021-2023
The endocannabinoid system is involved in the nociceptive and anti-inflammatory pathways, a lowered expression of CB2 receptors has been associated with inflammatory conditions, such as osteoarthritis (OA). This suggests that modulators could be novel therapeutic tools to treat OA. In present study, involvement Harpagophytum procumbens root extract, common ingredient nutraceuticals used joint disorders, modulation evaluated. Moreover, clarify effects pure single components, bioactive...
Viral respiratory tract infections (RTIs) are responsible for significant morbidity and mortality worldwide. A prominent feature of severe infections, such as acute syndrome coronavirus 2 (SARS-CoV-2) infection, is the cytokine release syndrome. Therefore, there an urgent need to develop different approaches both against viral replication consequent inflammation. N-acetylglucosamine (GlcNAc), a glucosamine (GlcN) derivative, has been developed immunomodulatory anti-inflammatory inexpensive...
Antimicrobial fibers based on biodegradable polymers, poly(lactic acid) (PLA), and poly(butylene adipate-co-terephthalate) (PBAT) are prepared by electrospinning. For this purpose, a biodegradable/bio-based polyitaconate containing azoles groups (PTTI) is incorporated at 10 wt.% into the electrospinning formulations. The resulting functionalized with azole moieties uniform free of beads. Then, accessible subjected to N-alkylation, treatment that provides cationic azolium antibacterial...
Pheomelanin is a natural yellow-reddish sulfur-containing pigment derived from tyrosinase-catalyzed oxidation of tyrosine in presence cysteine. Generally, the formation melanin pigments protective response against damaging effects UV radiation skin. However, pheomelanin, like other photosensitizing substances, can trigger, following exposure to radiation, photochemical reactions capable modifying and cellular components. The photoproperties this have been studied by analyzing pheomelanin...
Nanomedicine can represent a new strategy to treat several types of diseases such as those with inflammatory aetiology. Through this strategy, it is possible obtain nanoparticles controlled shape, size, and eventually surface charge. Moreover, the use molecules in nanoform may allow more effective delivery into diseased cells tissues, reducing toxicity side effects used compounds. The aim present manuscript was evaluation N-acetylglucosamine (GlcNAc NP) an vitro model osteoarthritis (OA)....