A5102839415- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Pharmaceutical Economics and Policy
- Renal cell carcinoma treatment
- Multiple Sclerosis Research Studies
- Autoimmune and Inflammatory Disorders Research
- Advances in Oncology and Radiotherapy
- Endometrial and Cervical Cancer Treatments
- Eosinophilic Esophagitis
- Lysosomal Storage Disorders Research
- Asthma and respiratory diseases
- Meta-analysis and systematic reviews
- Sleep and Work-Related Fatigue
- Hip and Femur Fractures
- Pharmaceutical studies and practices
- Emotion and Mood Recognition
- Complement system in diseases
- Aluminum toxicity and tolerance in plants and animals
- Mental Health via Writing
- Chemotherapy-induced cardiotoxicity and mitigation
- Female Genital Mutilation/Cutting Issues
- Psoriasis: Treatment and Pathogenesis
- Genetic Associations and Epidemiology
- Respiratory and Cough-Related Research
- Innovation Policy and R&D
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Yunnan University
2024
University of Michigan–Ann Arbor
2024
University of British Columbia
2018-2022
Icahn School of Medicine at Mount Sinai
2022
New York University Florence
2022
British Columbia Children's Hospital
2021
The University of Texas Southwestern Medical Center
2017
University of Hong Kong
2017
ABSTRACT Background Several matrix metalloproteinases (MMPs) have been reported to be associated with intervertebral disc degeneration (IDD) in several previous studies. However, the causal relationship between MMPs and IDD remains unclear. In this study, Mendelian randomization (MR) was used analyze plasma levels of multiple risk IDD. Methods The GWAS data MMP1, MMP3, MMP7, MMP10, MMP12 were derived from genome‐wide variation associations 21 758 European individuals. genetic variants...
We identified the first-generation antihistamine hydroxyzine as earliest and most frequently prescribed drug affecting central nervous system in children under age of 5 years province British Columbia, Canada (1. 1% prevalence). Whereas, antagonism H1-receptors exerts anti-pruritic effects atopic dermatitis diaper rash, animal studies suggest an adverse association between reduced neurotransmission histamine psychomotor behavior. In order to investigate safety, we characterized longitudinal...
Anthracyclines are widely used as part of chemotherapeutic regimens in paediatric oncology patients. The most serious adverse drug reaction caused by anthracycline use is cardiotoxicity, a condition that can lead to cardiac dysfunction and subsequent heart failure. Both clinical genetic factors contribute patient's risk experiencing anthracycline-induced cardiotoxicity. In particular, variants RARG, UGT1A6 SLC28A3 have been consistently shown influence an individual's this reaction. By...
Background: A small proportion of renal cell carcinoma (RCC) are associated with hereditary syndromes such as von Hippel-Lindau disease (VHL) and commonly treated surgical interventions. More recently, systemic treatments for VHL-associated RCC have been assessed an alternative to surgery. Methods: systematic literature review was conducted by searching MEDLINE, EMBASE, Cochrane Registry Controlled Trials collect interpret published evidence on patients better understand the treatment...
422 Background: Patients with advanced renal cell carcinoma (aRCC) have poor prognosis resulting in significant burden. In the KEYNOTE-581/CLEAR trial, pembrolizumab plus lenvatinib (P+L) as 1L therapy showed statistically and clinically meaningful improvements overall survival (OS), progression-free (PFS), response rate (ORR) versus sunitinib patients aRCC. This NMA synthesized evidence from randomized clinical trials (RCTs) to indirectly compare relative treatment effects of P+L vs...
421 Background: The International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk criteria is a widely used prognostic model in advanced RCC. Pembrolizumab plus lenvatinib (P+L) demonstrated significant improvement ORR, PFS, and OS versus sunitinib subjects with cc aRCC the KEYNOTE-581/CLEAR trial. This NMA indirectly compared efficacy of P+L to other therapies 1L within IMDC groups using data from randomized clinical trials (RCTs). Methods: A systematic literature review was...
Abstract The COVID-19 pandemic has had a significant impact on student life and academic performance. Moreover, different demographic groups have experienced the very differently. An important factor in learning process therefore performance is help seeking behaviors office hours. In this paper, we examine ways which affected use of _ onset expanded web-based educational tools. One example was an hours queue. When needed help, they added themselves to online queue instructors removed each...
The automatic video recognition of depression is becoming increasingly important in clinical applications. However, traditional models still face challenges practical applications, such as high computational costs, the poor application effectiveness facial movement features, and spatial feature degradation due to model stitching. To overcome these challenges, this work proposes a lightweight Time-Context Enhanced Depression Detection Network (TCEDN). We first use attention-weighted blocks...
Analyzing programs with loops is a challenging task, suffering from potential issues such as indeterminate number of iterations and exponential growth control flow complexity. Loop summarization, static analysis method for concrete semantic interpretation, receives increasing focuses. It produces symbolic expressions semantically equivalent to the loop program. However, current summarization methods are only suitable single-branch or multi-branch simple cycles, without supporting complex...
Since the outbreak of SARS-CoV-2, number globally confirmed cases COVID-19 has surpassed 20 million while reported deaths now exceed 750,000 [1]. In absence effective vaccines, authorities have implemented various forms social distancing, including travel bans, restrictions on gatherings, school closures, and confinement, guided in part by epidemiological models [2,3,4,5,6]. The pandemic economic impacts felt beyond health sector alone. Consumer retail, tourism, are sectors that been hard...
Composite renal end points and stage disease (ESRD) are frequently included as prespecified secondary in the cardiovascular outcomes trials (CVOTs) of diabetes medications. We examined heterogeneity definitions composite point ESRD CVOTs. Five criteria (macroalbuminuria, doubling serum creatinine, estimated glomerular filtration rate [GFR], death), were considered for across trials. Only three 12 all five criteria, whereas other different combinations four, two criteria. definition also...