A5062467963- Essential Oils and Antimicrobial Activity
- Malaria Research and Control
- Traditional and Medicinal Uses of Annonaceae
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Respiratory and Cough-Related Research
- Ginger and Zingiberaceae research
- Healthcare and Venom Research
- Plant Toxicity and Pharmacological Properties
- Ziziphus Jujuba Studies and Applications
- Piperaceae Chemical and Biological Studies
- Computational Drug Discovery Methods
- Natural product bioactivities and synthesis
- Herbal Medicine Research Studies
- Phytochemicals and Medicinal Plants
- Ethnobotanical and Medicinal Plants Studies
- HIV/AIDS drug development and treatment
- Helminth infection and control
- Alkaloids: synthesis and pharmacology
- Adolescent Sexual and Reproductive Health
- Phytochemistry and biological activity of medicinal plants
- Diverse Scientific Research Studies
- Allergic Rhinitis and Sensitization
University of Pretoria
2021-2024
University of the Witwatersrand
2024
Introduction: A significant number of the South African population still rely on traditional medicines (TM) for their primary healthcare. However, little to no scientific data is available effects most TM products cytokine and cellular biomarkers immune response. We evaluated impact a [Product Nkabinde (PN)] in inducing response peripheral blood mononuclear cells (PBMCs). Methods: PN, combination four indigenous plants was used this study. The IC 50 established using cell viability assay...
Despite the success of combination antiretroviral therapy (cART), HIV persists in low- and middle-income countries (LMIC) due to emerging drug resistance insufficient accessibility. Furthermore, cART does not target latently-infected CD4+ T cells, which represent a major barrier eradication. The “shock kill” therapeutic approach aims reactivate provirus expression cells presence virus-expressing for elimination. An attractive prototype LMICs would therefore be capable simultaneously...
Pelargonium sidoides DC. (Geraniaceae) is an important indigenous medicinal plant in South Africa, historically employed by various ethnic groups to treat respiratory and gastrointestinal ailments. The proprietary herbal tincture, Umckaloabo®, utilizes ethanolic extract (EPs® 7630) from the roots of P. sidoides, has demonstrated effectiveness alleviating symptoms infections. contain numerous highly oxygenated coumarins phenolic metabolites, notably marker compound umckalin. While Umckaloabo®...
Two field cases of reddish-black pigmenturia occurred where cattle grazed on an established Cenchrus ciliaris (blue buffalo grass) pasture in South Africa. The was noticeably invaded by Indigofera cryptantha, which heavily grazed. Apart from the discolored urine, no other clinical abnormalities were detected. Urinalysis revealed hemoglobinuria, proteinuria and alkaline pH. When animals immediately removed infested pasture, they made uneventful recovery. However, a bull died when one herds...
The antimalarial drug-resistance conundrum which threatens to reverse the great strides taken curb malaria scourge warrants an urgent need find novel chemical scaffolds serve as templates for development of new drugs. Plants represent a viable alternative source discovery unique potential antiplasmodial scaffolds. To expedite compounds from plants, aim this study was use phylogenetic analysis identify higher plant orders and families that can be rationally prioritised drug discovery. We...
The emergence and spread of drug-recalcitrant Plasmodium falciparum parasites threaten to reverse the gains made in fight against malaria. Urgent measures need be taken curb this impending challenge. higher plant-derived sesquiterpene, quinoline alkaloids, naphthoquinone natural product classes compounds have previously served as phenomenal chemical scaffolds from which integral antimalarial drugs were developed. Historical successes serve an inspiration for continued investigation products...
The COVID-19 pandemic continues to be a global health concern despite numerous efforts being undertaken curb it. This has necessitated the urgent need seek more complementary tools, including drugs, treat this disease. Inspired by fact that natural products have historically served as source of chemical scaffolds for development current study aims interrogate South African biodiversity in search novel anti-viral agents against SARS-CoV-2. A dual approach was adopted where in-silico screening...
Ethnopharmacological relevance: Aloe marlothii A.Berger (Asphodelaceae) is indigenous to southern African countries where its aqueous preparations are used in traditional medicine treat several ailments including hypertension, respiratory infections, venereal diseases, chest pain, sore throat and malaria.Aim of the study: The aims this study were as follows: (i) isolate identify antiplasmodial active compounds A. roots water extract was previously inactive, dichloromethane:methanol...