A5088702531- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Sarcoidosis and Beryllium Toxicity Research
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral Infections and Immunology Research
- Peptidase Inhibition and Analysis
- ECG Monitoring and Analysis
- Genetic Associations and Epidemiology
- Cardiac Arrest and Resuscitation
- Advanced MRI Techniques and Applications
- Lipoproteins and Cardiovascular Health
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Cardiovascular Syncope and Autonomic Disorders
- Pain Management and Treatment
- Sports injuries and prevention
Universitätsklinikum Gießen und Marburg
2024-2025
Leipzig Heart Institute
2015-2024
Leipzig University
2012-2024
Justus-Liebig-Universität Gießen
2023-2024
Deutsches Herzzentrum der Charité
2018-2022
Democritus University of Thrace
2022
Helios Kliniken
2018-2021
University Children's Hospital Tübingen
2017
Background— Data on the outcomes of ventricular tachycardia (VT) ablation in nonischemic dilated cardiomyopathy (NIDCM) are insufficient. The Heart Center Leipzig VT (HELP-VT) study was conducted prospectively to compare after radiofrequency catheter patients with NIDCM compared ischemic (ICM). Methods and Results— Two hundred twenty-seven patients, 63 164 ICM, presenting sustained were ablated ablation. Noninducibility any clinical nonclinical achieved 66.7% 77.4% ICM patients. Ablation...
Abstract There is an increasing proportion of the general population surviving to old age with significant chronic disease, multi-morbidity, and disability. The prevalence pre-frail state frailty syndrome increases exponentially advancing associated greater morbidity, disability, hospitalization, institutionalization, mortality, health care resource use. Frailty represents a global problem, making early identification, evaluation, treatment prevent cascade events leading from functional...
This randomized single-centre study sought to compare the efficacy and safety of pulmonary vein isolation (PVI) plus voltage-guided ablation vs. PVI with or without linear depending on type atrial fibrillation (AF). Overall, 124 ablation-naive patients paroxysmal persistent AF were (persistent AF) (paroxysmal additional (control group) low-voltage areas (LVAs) irrespective type. Bipolar voltage mapping was performed during stable sinus rhythm. An LVA consisted ≥ 3 adjacent points that each...
The aim of the study was to determine incidence oesophageal lesions after radiofrequency ablation (RFA) atrial fibrillation (AF) with or without use temperature probes.Two hundred patients were prospectively randomized into two groups: OPERA+ group underwent RFA using probes (SensiTherm™); OPERA- received fixed energy levels 25 W at posterior wall an probe. All post-interventional endoscopy and Holter-electrocardiogram 6 months. (Clinical.Trials.gov: NCT03246594). One in 100 OPERA-. drop-out...
The effects of time to referral for catheter ablation (CA) scar-related ventricular tachycardia (VT) on acute success, VT recurrence, and cardiac mortality are unclear.We investigated 300 patients after CA sustained VT. was performed within 30 days the first documented in 75 (25%) (group 1), between 1 month year 84 (28%) 2), >1 occurrence 141 (47%) 3). end points were noninducibility any (acute success), recurrence 2 years. Acute success achieved 66 (88%) group 1, 68 (81%) 2, 99 (70.2%) 3...
There remains a lack of consensus regarding the ideal ablation strategy for atrial fibrillation (AF), particularly in patients with persistent or longstanding AF. Given increasing evidence from clinical imaging studies that rotors sustain AF, rotor elimination may be desirable procedural endpoint. However, there is no description to date outcomes using during as Moreover, series question whether AF termination endpoint after many forms ablation.We report single-center experience Focal...
Background— Data on outcomes after catheter ablation of ventricular tachycardia (VT) in patients with nonischemic dilated cardiomyopathy (NIDCM) are insufficient. We aimed to investigate the effects successful VT cardiac mortality NIDCM. Methods and Results— One hundred two NIDCM (86 men; mean age, 58.8±15.2 years; ejection fraction, 33.3±11.9%) underwent ablation. After ablation, a programmed stimulation test for success was performed. Complete noninducibility achieved 62 (61%) partial or...
We aim to provide a critical appraisal of basic concepts underlying signal recording and processing technologies applied for (i) atrial fibrillation (AF) mapping unravel AF mechanisms and/or identifying target sites therapy (ii) detection, optimize usage technologies, stimulate research aimed at closing knowledge gaps, developing ideal technologies. Recording techniques assessment electrical activity during essential diagnosis guiding ablative including body surface electrocardiograms (ECG)...
The ultra-low-temperature cryoablation (ULTC) ablation system using -196°C N2 cryogen has been reported to create lesions with freeze duration-dependent depth titratable over 10 mm minimum attenuation by scar. Cryocure-VT (NCT04893317) was a first-in-human clinical trial evaluating the safety and efficacy of novel, purpose-built ULTC catheter in endocardial scar-dependent ventricular tachycardias (VTs).
Abstract Arrhythmia recurrences after catheter ablation of atrial fibrillation (AF) cause intensive treatment costs. Left electro-anatomical remodeling measured as low voltage areas (LVA) during indicates advanced disease stage and is associated with poor success. The aim this study was to analyze the prediction LVA arrhythmia using APPLE, DR-FLASH MB-LATER scores. scores were calculated at baseline 3 months post-ablation in AF patients undergoing first ablation. determined high-density maps...
Background Galectin-3 (Gal-3) is an emerging biomarker in heart failure that involved fibrosis and inflammation. However, its potential value as a prognostic marker atrial fibrillation (AF) unknown. The aim of this study was to assess the impact AF catheter ablation on Gal-3 evaluate for predicting rhythm outcome after ablation. Methods measured at baseline 6 months using specific ELISA. recurrences were defined any arrhythmia lasting longer than 30 sec within Results In 105 patients (65%...
Long‐Term Efficacy of Single Procedure Remote Magnetic Catheter Navigation . Background: magnetic navigation (RMN) aims to reduce some inherent limitations manual radiofrequency (RF) ablation. However, data comparing the effectiveness both methods are scarce. This study evaluated acute and long‐term success RMN guided versus RF ablation in patients with ischemic sustained ventricular tachycardia (sVT). Methods: One hundred two consecutive (age 68 ± 10 years, LVEF 32 12%, 88 men) sVT were...
Background— Recent studies reported worse outcomes after atrial fibrillation (AF) ablation in patients with metabolic syndrome (MetS). However, mechanisms of AF recurrence MetS remain unclear. Method and Results— We performed pulmonary vein isolation voltage mapping 236 (age 61±9.6 years; persistent 64%; 54%). Left (LA) low areas were semiquantitatively estimated presented as index. was defined according to National Cholesterol Education Program Adult Treatment Panel III. Follow-up for ≤12...
Abstract Background The most likely origin of premature ventricular contractions (PVCs) may be deduced from surface electrocardiogram (ECG) analysis while planning an electrophysiological study (EPS). Apart purely benign forms increased ectopy, myocardial substrate (e.g., regional fibrosis) present in certain cases, which will significantly impact the ablation approach. Cardiac magnetic resonance (CMR) imaging can reliably identify fibrotic target lesions and, hence, assist adequate patient...
Cardiac electrophysiology has moved a long way forward during recent decades in the comprehension and treatment of complex cardiac arrhythmias. Contemporary electroanatomical mapping systems, along with state-of-the-art technology manufacture catheters imaging modalities, have significantly enriched our armamentarium, enabling implementation various strategies techniques procedures. Beyond conventional strategies, ablation fractionated electrograms rotor atrial fibrillation procedures,...