A5053645821- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Mechanical Circulatory Support Devices
- ECG Monitoring and Analysis
- Neurological disorders and treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Ultrasound and Hyperthermia Applications
- Heart Rate Variability and Autonomic Control
- Viral Infections and Immunology Research
- Vascular anomalies and interventions
- Public Administration and Political Analysis
- Cardiac Health and Mental Health
- Pain Management and Treatment
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
Leipzig Heart Institute
2015-2025
Helios Kliniken
2025
Maastricht University Medical Centre
2023-2025
Leipzig University
2015-2024
Deutsches Herzzentrum der Charité
2021-2022
The ultra-low-temperature cryoablation (ULTC) ablation system using -196°C N2 cryogen has been reported to create lesions with freeze duration-dependent depth titratable over 10 mm minimum attenuation by scar. Cryocure-VT (NCT04893317) was a first-in-human clinical trial evaluating the safety and efficacy of novel, purpose-built ULTC catheter in endocardial scar-dependent ventricular tachycardias (VTs).
Atrial fibrillation (AF) is associated with frequent appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapies. Catheter ablation of AF has been shown to reduce burden improve left ventricular function in heart failure patients but the impact on ICD therapies not yet studied. The aim this study was test hypothesis that reduces cardiomyopathies.In 73 consecutive (mean age 59 ± 10 years, 85% male) previously implanted due ischaemic (n = 30) or dilated cardiomyopathy...
Abstract Background The International Consortium for Health Outcome Measurement (ICHOM) and EHRA advocate collection of patient-reported outcomes (PROs) benchmarking AF care. However, concerns over the robustness available outcome measures (PROMs) limits routine in clinical practice. Purpose This systematic review aimed to (1) identify PROMs used evaluate seven PROs (health related quality-of-life (HRQoL), physical, emotional cognitive function, symptom severity, exercise tolerance ability...
Abstract Aims Ablation of ventricular tachycardias (VTs) in patients with structural heart disease has been established the past decades as an effective and safe treatment. However, prognosis long-term outcome remains poor. Methods results We investigated 309 ischaemic cardiomyopathy (ICM) non-ischaemic (NICM) (186 ICM, 123 NICM; 271 males; mean age 64.1 ± 12 years; ejection fraction 34 13%) after ≥1 VT ablations over a follow-up period 28 months. Electrical storm was indication for 224...
Consumer smartwatches have gained attention as mobile health (mHealth) tools able to detect atrial fibrillation (AF) using photoplethysmography (PPG) or a short strip of electrocardiogram (ECG). PPG has limited accuracy due the movement artifacts, whereas ECG cannot be used continuously, is usually displayed single-lead signal and in asymptomatic cases.DoubleCheck-AF validation study wrist-worn device dedicated providing both continuous PPG-based rhythm monitoring instant 6-lead with no...
To evaluate the predictive value of preoperative echocardiographic parameters for occurrence VAs in patients with preexisting ICD undergoing LVAD implantation.
Atrial fibrillation (AF) is the most common human arrhythmia. Interventional treatment with catheter ablation an established technique that increasingly applied and has become one of main modalities in patients AF. Ablation results significant improvement symptoms quality life. There as yet no clear evidence any impact procedure on hard clinical endpoints, except heart failure, who seem to benefit significantly from ablation. The cornerstone achievement pulmonary vein isolation....
The incidence of postoperative complications following pacemaker or implantable cardioverter-defibrillator implantations in patients treated with new oral anticoagulation agents has not been studied. Here we present a first comparison after cardiac rhythm device (CRD) atrial fibrillation (AF) dabigatran uninterrupted warfarin.Using case-control study design, compared within 30 days 236 CRD procedures performed under warfarin (n=118) interrupted (n=118).There were no significant differences...
Abstract Aim Cardiac sympathetic denervation (CSD) has been introduced as a bailout therapy in patients with structural heart disease and refractory ventricular arrhythmias (VAs), but available data are scarce. Purpose of this study was to estimate immediate results, complications, mid-term outcomes CSD following recurrent VA after catheter ablation. Methods results Adult who underwent the Heart Center Leipzig from March 2017 February 2021 were retrospectively analysed. Follow-up (FU)...
Catheter ablation has become one of the main treatment strategies in patients with premature ventricular complexes (PVC). The successful mapping and can be performed an catheter without additional diagnostic catheters.
ABSTRACT Aim A recent European Heart Rhythm Association (EHRA) practical guide provides guidance on the use of novel digital devices for heart rhythm analysis using either electrocardiogram (ECG) or photoplethysmography (PPG) technology diagnosis atrial fibrillation (AF). This survey assesses physicians' preferences to in patients with possible AF and their impact clinical decision‐making. Methods Results Participants DAS‐CAM III initiated distributed an online assessing physician management...
Epicardial ablation has risen to an essential part of the treatment ventricular tachycardias (VTs). In this study, we report efficacy, risks, and current trends epicardial in structural heart disease as reported a tertiary single centre over 12-year period.Two hundred thirty-six patients referred for VT underwent successful access were included analysis (89% non-ischaemic cardiomyopathy, 90% males, mean age 60 years, left ejection fraction 38.4%). After performing clinical VTs eliminated 87%...
Same-day discharge (SDD) following catheter ablation (CA) of atrial fibrillation (AF) was already introduced in selected facilities Europe, but a widespread implementation has not yet succeeded. Data on patients' perspectives are lacking. Therefore, we conducted survey to address beliefs towards SDD and identify variables that associated with their evaluation.As part the prospective, monocentric FAST AFA trial, patients aged ≥20 years undergoing left CA for AF were asked participate...
Recurrences of ventricular tachycardia (VT) after initial catheter ablation is a significant clinical problem. In this study, we report the efficacy and risks repeat VT in patients with structural heart disease (SHD) tertiary single centre over 7-year period.
Implantable cardioverter-defibrillators (ICDs) have been shown to reduce mortality in patients with both ischaemic and non-ischaemic cardiomyopathy by terminating life-threatening arrhythmias. However, such arrhythmic events are unequally distributed among different patient subgroups. We aimed evaluate predictors of appropriate ICD therapies as a step towards risk stratification real-world cohort.The prevalence were analysed 330 consecutive (mean age 65 ± 11, 81% male) implanted ICDs due (n...
Background. Catheter ablation of ventricular tachycardia (VT) in patients with ischemic cardiomyopathy (ICM) is an effective tool to prevent VT recurrences. Chronic total occlusion (CTO) represents a clinically relevant entity ICM and independent predictor arrhythmia mortality. The effects CTO on the outcome are not well-studied. Objective. This analysis aimed identify impact CTO, revascularized, or ablation. Methods Results. Of 385 consecutive subjects ICM-VT who underwent catheter for...
Abstract Fully CMR-guided electrophysiological interventions (EP-CMR) have recently been introduced but data on the optimal CMR imaging protocol are scarce. This study determined clinical utility of 3D non-selective whole heart steady-state free precession using compressed SENSE (nsWHcs) for automatic segmentation cardiac cavities as basis targeted catheter navigation during EP-CMR cavo-tricuspid isthmus ablation. Fourty-two consecutive patients with isthmus-dependent right atrial flutter...
High-power-short-duration (HPSD) ablation is an effective treatment for atrial fibrillation but poses risks of thermal injuries to the oesophagus and vagus nerve. This study aims investigate incidence predictors injuries, employing machine learning.
Background Even after atrial fibrillation (AF) catheter ablation, many patients still experience relevant symptom burden. The objective of the MENTAL AF trial was to determine whether app‐based mental training (MT) during 3 months following pulmonary vein isolation reduces AF‐related symptoms. Methods and Results Patients scheduled for were enrolled randomized 1:1 either MT or usual care. Of 174 patients, 76 in 75 care group included final analysis. intervention delivered by a daily...