A5082666893- Collagen: Extraction and Characterization
- Bone Tissue Engineering Materials
- Seaweed-derived Bioactive Compounds
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Marine Invertebrate Physiology and Ecology
- Osteoarthritis Treatment and Mechanisms
- Planarian Biology and Electrostimulation
- Fibroblast Growth Factor Research
- Axon Guidance and Neuronal Signaling
- Head and Neck Cancer Studies
- Hippo pathway signaling and YAP/TAZ
- Voice and Speech Disorders
- Silk-based biomaterials and applications
- dental development and anomalies
- Tendon Structure and Treatment
- biodegradable polymer synthesis and properties
- Hydrogels: synthesis, properties, applications
Jellagen (United Kingdom)
2017-2024
Smith College
2018
Syracuse University
2018
University of Memphis
2018
Texas A&M University
2018
Louisiana State University Health Sciences Center New Orleans
2018
The University of Texas at San Antonio
2018
University of Kentucky
2018
University of Maryland, Baltimore County
2018
Cartilage repair after a trauma or degenerative disease like osteoarthritis (OA) continues to be big challenge in current medicine due the limited self-regenerative capacity of articular cartilage tissues. To overcome limitations, tissue engineering and regenerative (TERM) adjacent areas have focused their efforts on new therapeutical procedures materials capable restoring normal functionalities through polymeric scaffolding stem cell approaches. For this, sustainable exploration marine...
Abstract Jellyfish have emerged as a source of next generation collagen that is an attractive alternative to existing sources, such bovine and porcine, due plentiful supply providing safer through lack spongiform encephalopathy (BSE) transmission risk potential viral vectors, both which could be transmitted humans. Here we compare implantable sponges derived for the first time from Rhizostoma pulmo jellyfish. A further novelty research was there comparison were either uncrosslinked or...
Osteoarthritis (OA) is a multifactorial disease leading to degeneration of articular cartilage, causing morbidity in approximately 8.5 million the UK population. As dense extracellular matrix cartilage primarily composed collagen, repair strategies have exploited biocompatibility and mechanical strength bovine porcine collagen produce robust scaffolds for procedures such as matrix-induced chondrocyte implantation (MACI). However, mammalian sourced collagens pose safety risks spongiform...
This study provides a deeper understanding of the relationships between marine biopolymer structure/composition and rheological mechanical properties in ionic-linked hydrogel network-based formulations as sustainable process for tissue engineering.
Accurate disease models are essential for understanding pathogenesis and developing new therapeutics. As stem cells capable of self-renewal differentiation, they ideally suited both generating these obtaining the large quantities required drug development transplantation therapies. Jellyfish collagen is showing great promise as a next generation matrix enabling improved outcomes in 2D 3D cell culture regenerative medicine. Here, we report potential jellyfish culturing induced pluripotent...
Extracellular matrix type 0 is reported. The developed from a jellyfish collagen predating mammalian forms by over 0.5 billion years. With its ancient lineage, compositional simplicity, and resemblance to multiple types, the referred as extracellular 0. Here we validate describing physicochemical biological properties present it versatile, minimalist biomaterial underpinning pipeline of commercialised products under collective name JellaGelTM. We describe an extensive body evidence for...
Introduction Collagen is extensively utilised in regenerative medicine due to its highly desirable properties. However, collagen typically derived from mammalian sources, which poses several limitations, including high cost, potential risk of immunogenicity and transmission infectious diseases, ethical religious constraints. Jellyfish-sourced type 0 represents a safer more environmentally sustainable alternative source. Methods Thus, we investigated the jellyfish collagen-based hydrogels,...
Marine origin polymers represent a sustainable and natural alternative to mammal counterparts regarding the biomedical application due their similarities with proteins polysaccharides present in extracellular matrix (ECM) humans can reduce risks associated zoonosis overcoming social- religious-related constraints. In particular, collagen-based biomaterials have been widely explored tissue engineering scaffolding applications, where cryogels are of particular interest as low temperature...
Abstract Objectives/Hypothesis Compare proteomic profiles of rabbit vocal folds (VFs) injected with micronized cross‐linked jellyfish collagen “collagen Type 0” (MX‐JC) against two clinical products for injection medialization laryngoplasty (IL). Study Design Animal model. Methods Left recurrent laryngeal nerve sectioning and IL were performed in New Zealand White rabbits ( N = 6/group). Group 1 received adipose‐derived stem cells (ADSCs), 2, MX‐JC alone; 3, hyaluronic acid; 4, acellular...
The self-repair capacity of human tissue is limited, motivating the arising engineering (TE) in building temporary scaffolds that envisage regeneration tissues, including articular cartilage. However, despite large number preclinical data available, current therapies are not yet capable fully restoring entire healthy structure and function on this when significantly damaged. For reason, new biomaterial approaches needed, present work proposes development characterization innovative polymeric...
Jellyfish collagens exhibit auspicious perspectives for tissue engineering applications primarily due to their outstanding compatibility with a wide range of cell types, low immunogenicity and biodegradability. Furthermore, derived from non-mammalian source, jellyfish reduce the risk disease transmission, minimising therefore ethical safety concerns. The current study aims investigate potential 3-dimensional collagen sponges (3D-JCS) in promoting bone regeneration. Both qualitative...